Reaction: Cariprazine to 1 product

Reaction
Cariprazine
DB06016
Desmethyl cariprazine
DBMET03491
Reaction type
demethylation
Direction
Major circulating metabolite?
Yes
Spontaneous?
No
Activity
active
References
  1. Citrome L: Cariprazine: chemistry, pharmacodynamics, pharmacokinetics, and metabolism, clinical efficacy, safety, and tolerability. Expert Opin Drug Metab Toxicol. 2013 Feb;9(2):193-206. doi: 10.1517/17425255.2013.759211. [Article]
  2. FDA Approved Drug Products: VRAYLAR (cariprazine) capsules, for oral use [Link]
Comments
Not Available
Enzymes
EnzymeKmVmaxRole
Cytochrome P450 3A4Not AvailableNot Availableconfirmed
Cytochrome P450 2D6Not AvailableNot Availableconfirmed