Olsalazine sodiumProduct ingredient for Olsalazine
- Name
- Olsalazine sodium
- Drug Entry
- Olsalazine
Olsalazine is an aminosalicylate and a prodrug of mesalamine (5-aminosalicylic acid, 5-ASA).1 It was first developed for delivering mesalamine to the colon without the use of sulfapyridine.2 Olsalazine comprises two mesalamine molecules joined by an azo bridge, which is cleaved in the colon.2 Olsalazine is an anti-inflammatory agent that works by inhibiting cyclooxygenase and lipoxygenase, subsequently reducing the production of pro-inflammatory factors like prostaglandin and leukotriene.1 Olsalazine is used in the treatment of ulcerative colitis.5,6
- Accession Number
- DBSALT000191
- Structure
Structure for Olsalazine sodium (DBSALT000191)
- Synonyms
- Not Available
- UNII
- Y7JEW0XG7I
- CAS Number
- 6054-98-4
- Weight
- Average: 346.2027
Monoisotopic: 346.017775348 - Chemical Formula
- C14H8N2Na2O6
- InChI Key
- QQWFSVYVHLECFP-XBPUGJBTSA-L
- InChI
- InChI=1S/C14H10N2O6.2Na/c17-11-3-1-7(5-9(11)13(19)20)15-16-8-2-4-12(18)10(6-8)14(21)22;;/h1-6,15,17H,(H,19,20)(H,21,22);;/q;2*+1/p-2/b16-8-;;
- IUPAC Name
- disodium 5-{2-[(1Z)-3-carboxy-4-oxocyclohexa-2,5-dien-1-ylidene]hydrazin-1-yl}-2-oxidobenzoate
- SMILES
- [Na+].[Na+].OC(=O)C1=C\C(C=CC1=O)=N/NC1=CC(C([O-])=O)=C([O-])C=C1
- External Links
- PubChem Compound
- 54678919
- ChemSpider
- 4805076
- ChEBI
- 63614
- Wikipedia
- Olsalazine
- Predicted Properties
Property Value Source Water Solubility 0.668 mg/mL ALOGPS logP 2.04 ALOGPS logP 1.15 Chemaxon logS -2.7 ALOGPS pKa (Strongest Acidic) 2.67 Chemaxon pKa (Strongest Basic) 4.71 Chemaxon Physiological Charge -2 Chemaxon Hydrogen Acceptor Count 8 Chemaxon Hydrogen Donor Count 2 Chemaxon Polar Surface Area 141.95 Å2 Chemaxon Rotatable Bond Count 4 Chemaxon Refractivity 99.47 m3·mol-1 Chemaxon Polarizability 27.49 Å3 Chemaxon Number of Rings 2 Chemaxon Bioavailability 1 Chemaxon Rule of Five Yes Chemaxon Ghose Filter Yes Chemaxon Veber's Rule No Chemaxon MDDR-like Rule No Chemaxon