Minocycline hydrochlorideProduct ingredient for Minocycline
- Name
- Minocycline hydrochloride
- Drug Entry
- Minocycline
Minocycline was first described in the literacture in 1966.1 It is a second generation tetracycline antibiotic that is active against gram-negative and gram-positive bacteria.7 Like other semisynthetic tetracyclines, minocycline has modifications to carbons 7-9 on the D ring to generate higher efficacy than previous tetracyclines.7
Minocycline was granted FDA approval on 30 June 1971.9
- Accession Number
- DBSALT000721
- Structure
- Synonyms
- Minocycline HCl
- UNII
- 0020414E5U
- CAS Number
- 13614-98-7
- Weight
- Average: 493.94
Monoisotopic: 493.161578 - Chemical Formula
- C23H28ClN3O7
- InChI Key
- GLMUAFMGXXHGLU-VQAITOIOSA-N
- InChI
- InChI=1S/C23H27N3O7.ClH/c1-25(2)12-5-6-13(27)15-10(12)7-9-8-11-17(26(3)4)19(29)16(22(24)32)21(31)23(11,33)20(30)14(9)18(15)28;/h5-6,9,11,17,27,29-30,33H,7-8H2,1-4H3,(H2,24,32);1H/t9-,11-,17-,23-;/m0./s1
- IUPAC Name
- hydrogen (4S,4aS,5aR,12aS)-4,7-bis(dimethylamino)-3,10,12,12a-tetrahydroxy-1,11-dioxo-1,4,4a,5,5a,6,11,12a-octahydrotetracene-2-carboxamide chloride
- SMILES
- [H+].[Cl-].[H][C@@]12CC3=C(C(O)=CC=C3N(C)C)C(=O)C1=C(O)[C@]1(O)C(=O)C(C(N)=O)=C(O)[C@@H](N(C)C)[C@]1([H])C2
- External Links
- KEGG Drug
- D00850
- PubChem Compound
- 54685925
- ChemSpider
- 10482122
- ChEBI
- 50697
- ChEMBL
- CHEMBL1200881
- Wikipedia
- Minocycline
- Predicted Properties
Property Value Source Water Solubility 3.07 mg/mL ALOGPS logP -0.03 ALOGPS logP -2.5 Chemaxon logS -2.2 ALOGPS pKa (Strongest Acidic) 2.9 Chemaxon pKa (Strongest Basic) 7.9 Chemaxon Physiological Charge 0 Chemaxon Hydrogen Acceptor Count 9 Chemaxon Hydrogen Donor Count 5 Chemaxon Polar Surface Area 164.63 Å2 Chemaxon Rotatable Bond Count 3 Chemaxon Refractivity 122.54 m3·mol-1 Chemaxon Polarizability 46.18 Å3 Chemaxon Number of Rings 4 Chemaxon Bioavailability 1 Chemaxon Rule of Five Yes Chemaxon Ghose Filter No Chemaxon Veber's Rule No Chemaxon MDDR-like Rule No Chemaxon