Testosterone propionate is a slow-release anabolic steroid no longer used commonly for the treatment of androgen deficiency or promotion of anabolic effects on muscles. It is a synthetic androstane steroid derivative of testosterone in the form of 17β propionate ester of testosterone.
- Mechanism
- Curator reviewed
The effects of testosterone in humans and other vertebrates occur by way of two main mechanisms: by activation of the androgen receptor (directly or as DHT), and by conversion to estradiol and activation of certain estrogen receptors. Free testosterone (T) is transported into the cytoplasm of target tissue cells, where it can bind to the androgen receptor, or can be reduced to 5alpha-dihydrotestosterone (DHT) by the cytoplasmic enzyme 5alpha-reductase. The areas of binding are called hormone response elements (HREs), and influence transcriptional activity of certain genes, producing the androgen effects.
- Primary indication
- Testosterone propionate is used in veterinary practice in heifers in order to stimulate maximal growth.Curator reviewed · 7 structured indications
- Formula / weight
- C22H32O3 · 344.4877 g/mol (avg)
- First approval
- Canada, 2016
- Code names
- NRB-03689 · NSC-9166
Resolves to
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Which drugs share a target with Testosterone propionate, and which of those have an active Phase 3 trial?
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