Rivastigmine tartrateProduct ingredient for Rivastigmine
- Name
- Rivastigmine tartrate
- Drug Entry
- Rivastigmine
Rivastigmine is a parasympathomimetic or cholinergic agent for the treatment of mild to moderate dementia of the Alzheimer's type. Rivastigmine is a cholinesterase inhibitor that inhibits both butyrylcholinesterase and acetylcholinesterase.
- Accession Number
- DBSALT001252
- Structure
Structure for Rivastigmine tartrate (DBSALT001252)
- Synonyms
- Rivastigmine bitartrate / Rivastigmine hydrogen tartrate
- External IDs
- ENA 713 / ENA-713 / SDZ-ENA 713
- UNII
- 9IY2357JPE
- CAS Number
- 129101-54-8
- Weight
- Average: 400.428
Monoisotopic: 400.18456587 - Chemical Formula
- C18H28N2O8
- InChI Key
- GWHQHAUAXRMMOT-MBANBULQSA-N
- InChI
- InChI=1S/C14H22N2O2.C4H6O6/c1-6-16(5)14(17)18-13-9-7-8-12(10-13)11(2)15(3)4;5-1(3(7)8)2(6)4(9)10/h7-11H,6H2,1-5H3;1-2,5-6H,(H,7,8)(H,9,10)/t11-;1-,2-/m01/s1
- IUPAC Name
- (2R,3R)-2,3-dihydroxybutanedioic acid; 3-[(1S)-1-(dimethylamino)ethyl]phenyl N-ethyl-N-methylcarbamate
- SMILES
- O[C@H]([C@@H](O)C(O)=O)C(O)=O.CCN(C)C(=O)OC1=CC=CC(=C1)[C@H](C)N(C)C
- External Links
- KEGG Drug
- D02558
- ChemSpider
- 5293295
- ChEBI
- 64358
- ChEMBL
- CHEMBL1201092
- Wikipedia
- Rivastigmine
- Predicted Properties
Property Value Source Water Solubility 2.04 mg/mL ALOGPS logP 2.45 ALOGPS logP 2.41 Chemaxon logS -2.1 ALOGPS pKa (Strongest Basic) 8.8 Chemaxon Physiological Charge 1 Chemaxon Hydrogen Acceptor Count 2 Chemaxon Hydrogen Donor Count 0 Chemaxon Polar Surface Area 32.78 Å2 Chemaxon Rotatable Bond Count 8 Chemaxon Refractivity 73.37 m3·mol-1 Chemaxon Polarizability 28.59 Å3 Chemaxon Number of Rings 1 Chemaxon Bioavailability 1 Chemaxon Rule of Five Yes Chemaxon Ghose Filter Yes Chemaxon Veber's Rule Yes Chemaxon MDDR-like Rule No Chemaxon