Propacetamol hydrochlorideProduct ingredient for Propacetamol
- Name
- Propacetamol hydrochloride
- Drug Entry
- Propacetamol
Propacetamol is a non-opioid analgesic devoid of the major contraindications.1 It is a derivative of acetaminophen, or paracetamol, with the molecular formula glycine, N, N-diethyl-,4-(acetylamino)phenyl ester. Propacetamol is a parenteral formulation of paracetamol and thus, it is a prodrug that is completely hydrolyzed to paracetamol.3 It is not available in the United States but this prodrug has been widely used in other countries such as France since 1985.5
- Accession Number
- DBSALT001284
- Structure
Structure for Propacetamol hydrochloride (DBSALT001284)
- Synonyms
- Propacetamol HCl
- UNII
- SH41QYH8E5
- CAS Number
- 66532-86-3
- Weight
- Average: 300.78
Monoisotopic: 300.1240702 - Chemical Formula
- C14H21ClN2O3
- InChI Key
- WGTYJNGARJPYKG-UHFFFAOYSA-N
- InChI
- InChI=1S/C14H20N2O3.ClH/c1-4-16(5-2)10-14(18)19-13-8-6-12(7-9-13)15-11(3)17;/h6-9H,4-5,10H2,1-3H3,(H,15,17);1H
- IUPAC Name
- 4-acetamidophenyl 2-(diethylamino)acetate hydrochloride
- SMILES
- Cl.CCN(CC)CC(=O)OC1=CC=C(NC(C)=O)C=C1
- External Links
- KEGG Drug
- D08434
- ChemSpider
- 97183
- ChEMBL
- CHEMBL1795480
- Predicted Properties
Property Value Source Water Solubility 0.513 mg/mL ALOGPS logP 1.96 ALOGPS logP 1.42 Chemaxon logS -2.7 ALOGPS pKa (Strongest Acidic) 14.67 Chemaxon pKa (Strongest Basic) 6.83 Chemaxon Physiological Charge 1 Chemaxon Hydrogen Acceptor Count 3 Chemaxon Hydrogen Donor Count 1 Chemaxon Polar Surface Area 58.64 Å2 Chemaxon Rotatable Bond Count 7 Chemaxon Refractivity 74.98 m3·mol-1 Chemaxon Polarizability 29.5 Å3 Chemaxon Number of Rings 1 Chemaxon Bioavailability 1 Chemaxon Rule of Five Yes Chemaxon Ghose Filter Yes Chemaxon Veber's Rule No Chemaxon MDDR-like Rule No Chemaxon