Isoproterenol sulfateProduct ingredient for Isoprenaline
- Name
- Isoproterenol sulfate
- Drug Entry
- Isoprenaline
Isoprenaline is a non-selective beta adrenergic receptor agonist indicated to treat heart block, Adams-Stokes attacks, bronchospasm in anesthesia, cadiac arrest, hypovolemic shocks, septic shock, hypoperfusion, congestive hear failure, and cardiogenic shock.2,14
Isoprenaline research in the 1940s found that this isopropyl analog of epinephrine dilated the bronchi, as well as raising the heart rate and cardiac output, without vasoconstriction.11,12 The US patent from 1943 states that this compound had a wider therapeutic index and a stronger action than adrenaline.16
Isoprenaline was granted FDA approval on 19 February 1948.13
- Accession Number
- DBSALT001403
- Structure
Structure for Isoproterenol sulfate (DBSALT001403)
- Synonyms
- Not Available
- UNII
- 925FX3X776
- CAS Number
- 6078-56-4
- Weight
- Average: 556.62
Monoisotopic: 556.23019591 - Chemical Formula
- C22H40N2O12S
- InChI Key
- CUQPTVCVZLUXJB-UHFFFAOYSA-N
- InChI
- InChI=1S/2C11H17NO3.H2O4S.2H2O/c2*1-7(2)12-6-11(15)8-3-4-9(13)10(14)5-8;1-5(2,3)4;;/h2*3-5,7,11-15H,6H2,1-2H3;(H2,1,2,3,4);2*1H2
- IUPAC Name
- bis(4-{1-hydroxy-2-[(propan-2-yl)amino]ethyl}benzene-1,2-diol) sulfuric acid dihydrate
- SMILES
- O.O.OS(O)(=O)=O.CC(C)NCC(O)C1=CC=C(O)C(O)=C1.CC(C)NCC(O)C1=CC=C(O)C(O)=C1
- External Links
- ChemSpider
- 571019
- ChEMBL
- CHEMBL3989521
- Wikipedia
- Isoprenaline
- Predicted Properties
Property Value Source Water Solubility 5.86 mg/mL ALOGPS logP -0.27 ALOGPS logP 0.24 Chemaxon logS -1.6 ALOGPS pKa (Strongest Acidic) 9.81 Chemaxon pKa (Strongest Basic) 8.96 Chemaxon Physiological Charge 1 Chemaxon Hydrogen Acceptor Count 4 Chemaxon Hydrogen Donor Count 4 Chemaxon Polar Surface Area 72.72 Å2 Chemaxon Rotatable Bond Count 8 Chemaxon Refractivity 58.4 m3·mol-1 Chemaxon Polarizability 23.11 Å3 Chemaxon Number of Rings 2 Chemaxon Bioavailability 1 Chemaxon Rule of Five No Chemaxon Ghose Filter No Chemaxon Veber's Rule No Chemaxon MDDR-like Rule No Chemaxon