Nitrofurantoin sodiumProduct ingredient for Nitrofurantoin

Nitrofurantoin is a nitrofuran antibiotic used to treat uncomplicated urinary tract infections.^8,9,10 Nitrofurantoin is converted by bacterial nitroreductases to electrophilic intermediates which inhibit the citric acid cycle as well as synthesis of DNA, RNA, and protein.² This drug is more resistant to the development of bacterial resistance because it acts on many targets at once.² Nitrofurantoin is a second line treatment to trimethoprim/sulfamethoxazole.³

Nitrofurantoin was granted FDA approval on 6 February 1953.¹¹