Pheniramine maleateProduct ingredient for Pheniramine

Name
Pheniramine maleate
Drug Entry
Pheniramine

Pheniramine is a first generation antihistamine in the alkylamine class, similar to brompheniramine and chlorpheniramine.3 It is used in some over-the-counter allergy as well as cold & flu products in combination with other drugs. Pheniramine's use as an anti-allergy medication has largely been supplanted by second generation antihistamines such as [cetirazine] and [loratidine].

Accession Number
DBSALT001440
Structure
Thumb
Synonyms
Not Available
UNII
NYW905655B
CAS Number
132-20-7
Weight
Average: 356.422
Monoisotopic: 356.173607261
Chemical Formula
C20H24N2O4
InChI Key
SSOXZAQUVINQSA-BTJKTKAUSA-N
InChI
InChI=1S/C16H20N2.C4H4O4/c1-18(2)13-11-15(14-8-4-3-5-9-14)16-10-6-7-12-17-16;5-3(6)1-2-4(7)8/h3-10,12,15H,11,13H2,1-2H3;1-2H,(H,5,6)(H,7,8)/b;2-1-
IUPAC Name
(2Z)-but-2-enedioic acid; dimethyl[3-phenyl-3-(pyridin-2-yl)propyl]amine
SMILES
[H]\C(=C(/[H])C(O)=O)C(O)=O.CN(C)CCC(C1=CC=CC=C1)C1=CC=CC=N1
KEGG Compound
C12574
ChemSpider
4445339
ChEBI
31990
ChEMBL
CHEMBL1653
Wikipedia
Pheniramine
Predicted Properties
PropertyValueSource
Water Solubility0.377 mg/mLALOGPS
logP2.85ALOGPS
logP2.98ChemAxon
logS-2.8ALOGPS
pKa (Strongest Basic)9.48ChemAxon
Physiological Charge1ChemAxon
Hydrogen Acceptor Count2ChemAxon
Hydrogen Donor Count0ChemAxon
Polar Surface Area16.13 Å2ChemAxon
Rotatable Bond Count7ChemAxon
Refractivity76.05 m3·mol-1ChemAxon
Polarizability28.38 Å3ChemAxon
Number of Rings2ChemAxon
Bioavailability1ChemAxon
Rule of FiveYesChemAxon
Ghose FilterYesChemAxon
Veber's RuleYesChemAxon
MDDR-like RuleNoChemAxon