Mycophenolate sodiumProduct ingredient for Mycophenolic acid
- Name
- Mycophenolate sodium
- Drug Entry
- Mycophenolic acid
Mycophenolic acid is a potent immunosuppressant agent that inhibits de novo purine biosynthesis.7 It was derived from Penicillium stoloniferum, and has also shown antibacterial, antifungal and antiviral properties.1. Mycophenolic acid is used in immunosuppressive regimens as part of a triple therapy that includes a calcineurin inhibitor (ciclosporin or tacrolimus) and prednisolone.2 This regimen can be used in place of the older anti-proliferative azathioprine due to its stronger immunosuppressive potency.3 However, mycophenolic acid treatment is more expensive and requires therapeutic drug monitoring to optimize efficacy and minimize toxicity.3,4 Mycophenolic acid is available as enteric-coated tablets of delayed-release, in an effort to improve upper gastrointestinal adverse events by delaying mycophenolic acid release until it reaches the small intestine.5 Mycophenolate mofetil, a prodrug of mycophenolic acid, is also prescribed to transplant recipients to prevent organ rejection.8
- Accession Number
- DBSALT001740
- Structure
Structure for Mycophenolate sodium (DBSALT001740)
- Synonyms
- Not Available
- UNII
- WX877SQI1G
- CAS Number
- 37415-62-6
- Weight
- Average: 342.323
Monoisotopic: 342.10793261 - Chemical Formula
- C17H19NaO6
- InChI Key
- DOZYTHNHLLSNIK-JOKMOOFLSA-M
- InChI
- InChI=1S/C17H20O6.Na/c1-9(5-7-13(18)19)4-6-11-15(20)14-12(8-23-17(14)21)10(2)16(11)22-3;/h4,20H,5-8H2,1-3H3,(H,18,19);/q;+1/p-1/b9-4+;
- IUPAC Name
- sodium (4E)-6-(4-hydroxy-6-methoxy-7-methyl-3-oxo-1,3-dihydro-2-benzofuran-5-yl)-4-methylhex-4-enoate
- SMILES
- [Na+].COC1=C(C\C=C(/C)CCC([O-])=O)C(O)=C2C(=O)OCC2=C1C
- External Links
- ChemSpider
- 4938872
- ChEBI
- 67155
- ChEMBL
- CHEMBL2106643
- Predicted Properties
Property Value Source Water Solubility 0.0571 mg/mL ALOGPS logP 2.7 ALOGPS logP 3.53 Chemaxon logS -3.8 ALOGPS pKa (Strongest Acidic) 3.57 Chemaxon pKa (Strongest Basic) -4.1 Chemaxon Physiological Charge -1 Chemaxon Hydrogen Acceptor Count 5 Chemaxon Hydrogen Donor Count 1 Chemaxon Polar Surface Area 95.89 Å2 Chemaxon Rotatable Bond Count 6 Chemaxon Refractivity 96.07 m3·mol-1 Chemaxon Polarizability 32.42 Å3 Chemaxon Number of Rings 2 Chemaxon Bioavailability 1 Chemaxon Rule of Five Yes Chemaxon Ghose Filter Yes Chemaxon Veber's Rule No Chemaxon MDDR-like Rule No Chemaxon