Mazindol hydrochlorideProduct ingredient for Mazindol
- Name
- Mazindol hydrochloride
- Drug Entry
- Mazindol
Mazindol is a tricyclic anorexigenic agent that is unrelated to and less toxic than amphetamine, but with some similar side effects. It inhibits uptake of catecholamines and blocks the binding of cocaine to the dopamine uptake transporter. Mazindol is only approved in the United States for the treatment of Duchenne muscular dystrophy, and is not marketed or available in the United States for use in the treatment of obesity.
- Accession Number
- DBSALT002359
- Structure
Structure for Mazindol hydrochloride (DBSALT002359)
- Synonyms
- Not Available
- UNII
- TYC95TXB8Q
- CAS Number
- 58535-70-9
- Weight
- Average: 321.2
Monoisotopic: 320.0483185 - Chemical Formula
- C16H14Cl2N2O
- InChI Key
- NIUFFPYONFMTAH-UHFFFAOYSA-N
- InChI
- InChI=1S/C16H13ClN2O.ClH/c17-12-7-5-11(6-8-12)16(20)14-4-2-1-3-13(14)15-18-9-10-19(15)16;/h1-8,20H,9-10H2;1H
- IUPAC Name
- 5-(4-chlorophenyl)-2H,3H,5H-imidazo[2,1-a]isoindol-5-ol hydrochloride
- SMILES
- Cl.OC1(N2CCN=C2C2=CC=CC=C12)C1=CC=C(Cl)C=C1
- External Links
- ChemSpider
- 2305035
- Predicted Properties
Property Value Source Water Solubility 0.139 mg/mL ALOGPS logP 2.64 ALOGPS logP 3.44 Chemaxon logS -3.3 ALOGPS pKa (Strongest Acidic) 11.61 Chemaxon pKa (Strongest Basic) 3.86 Chemaxon Physiological Charge 0 Chemaxon Hydrogen Acceptor Count 3 Chemaxon Hydrogen Donor Count 1 Chemaxon Polar Surface Area 35.83 Å2 Chemaxon Rotatable Bond Count 1 Chemaxon Refractivity 79.42 m3·mol-1 Chemaxon Polarizability 29.41 Å3 Chemaxon Number of Rings 4 Chemaxon Bioavailability 1 Chemaxon Rule of Five Yes Chemaxon Ghose Filter Yes Chemaxon Veber's Rule Yes Chemaxon MDDR-like Rule No Chemaxon