- Cupric sulfate pentahydrate
- Drug Entry
- Cupric sulfate
Cupric sulfate is a salt created by treating cupric oxide with sulfuric acid. This forms as large, bright blue crystals containing five molecules of water (CuSO4∙5H2O) and is also known as blue vitriol. The anhydrous salt is created by heating the hydrate to 150 °C (300 °F). Cupric sulfate is used primarily for agricultural purposes, as a pesticide, germicide, feed additive, and soil additive. Some of its secondary uses are as a raw material in the preparation of other copper compounds, as a reagent in analytic chemistry, as an electrolyte for batteries and electroplating baths, and in medical practice as a locally applied fungicide, bactericide, and astringent 9.
Copper is an essential trace element and an important catalyst for heme synthesis and iron absorption. After zinc and iron, copper is the third most abundant trace element found in the human body. Copper is a noble metal and its properties include high thermal and electrical conductivity, low corrosion, alloying ability, and malleability. Copper is a component of intrauterine contraceptive devices (IUD) and the release of copper is necessary for their important contraceptive effects. The average daily intake of copper in the USA is approximately 1 mg Cu with the diet being a primary source 5.
Interestingly, the dysregulation of copper has been studied with a focus on neurodegenerative diseases, such as Wilson’s disease, Alzheimer’s disease, and Parkinson’s disease. Data from clinical observations of the neurotoxic effects of copper may provide the basis for future treatments affecting copper and its homeostasis 15.
- Accession Number
- Copper sulfate pentahydrate / copper(II) sulfate, pentahydrate / Cupric sulfate
- CAS Number
- Average: 249.685
- Chemical Formula
- InChI Key
- IUPAC Name
- copper(2+) pentahydrate sulfate
- Predicted Properties
Property Value Source Water Solubility 45.7 mg/mL ALOGPS logP -0.12 ALOGPS logP -0.84 ChemAxon logS -0.67 ALOGPS pKa (Strongest Acidic) -3 ChemAxon Physiological Charge -2 ChemAxon Hydrogen Acceptor Count 4 ChemAxon Hydrogen Donor Count 0 ChemAxon Polar Surface Area 80.26 Å2 ChemAxon Rotatable Bond Count 0 ChemAxon Refractivity 11.53 m3·mol-1 ChemAxon Polarizability 5.81 Å3 ChemAxon Number of Rings 0 ChemAxon Bioavailability 1 ChemAxon Rule of Five Yes ChemAxon Ghose Filter No ChemAxon Veber's Rule No ChemAxon MDDR-like Rule No ChemAxon