Durlobactam sodiumProduct ingredient for Durlobactam
- Name
- Durlobactam sodium
- Drug Entry
- Durlobactam
Durlobactam is a diazabicyclooctane non-beta-lactam, beta-lactamase inhibitor. It is typically given in combination with sulbactam to protect it from degradation by certain serine-beta-lactamases.4 The combination product of durlobactam and sulbactam was first approved by the FDA in May 2023.3 It is used to treat hospital-acquired bacterial pneumonia and ventilator-associated bacterial pneumonia (HABP/VABP), caused by susceptible isolates of Acinetobacter baumannii-calcoaceticus complex.4
- Accession Number
- DBSALT003190
- Structure
Structure for Durlobactam sodium (DBSALT003190)
- Synonyms
- Durlobactam sodium
- External IDs
- ETX2514 sodium
- UNII
- F78MDZ9CW9
- CAS Number
- 1467157-21-6
- Weight
- Average: 299.23
Monoisotopic: 299.01880051 - Chemical Formula
- C8H10N3NaO6S
- InChI Key
- WHHNOICWPZIYKI-IBTYICNHSA-M
- InChI
- InChI=1S/C8H11N3O6S.Na/c1-4-2-5-3-10(6(4)7(9)12)8(13)11(5)17-18(14,15)16;/h2,5-6H,3H2,1H3,(H2,9,12)(H,14,15,16);/q;+1/p-1/t5-,6+;/m1./s1
- IUPAC Name
- sodium (2S,5R)-2-carbamoyl-3-methyl-7-oxo-1,6-diazabicyclo[3.2.1]oct-3-en-6-yl sulfate
- SMILES
- [Na+].CC1=C[C@@H]2CN([C@@H]1C(N)=O)C(=O)N2OS([O-])(=O)=O
- External Links
- ChemSpider
- 71060725
- ChEMBL
- CHEMBL4297378
- Predicted Properties
Property Value Source Water Solubility 11.3 mg/mL ALOGPS logP -0.31 ALOGPS logP -1.6 Chemaxon logS -1.4 ALOGPS pKa (Strongest Acidic) -1.9 Chemaxon pKa (Strongest Basic) -4.6 Chemaxon Physiological Charge -1 Chemaxon Hydrogen Acceptor Count 5 Chemaxon Hydrogen Donor Count 1 Chemaxon Polar Surface Area 133.07 Å2 Chemaxon Rotatable Bond Count 3 Chemaxon Refractivity 56.45 m3·mol-1 Chemaxon Polarizability 23.36 Å3 Chemaxon Number of Rings 2 Chemaxon Bioavailability 1 Chemaxon Rule of Five Yes Chemaxon Ghose Filter No Chemaxon Veber's Rule No Chemaxon MDDR-like Rule No Chemaxon