Search

Displaying results 91 - 100 of 605 in total
  1. Target

    Platelet-activating factor receptor

    go.drugbank.com/bio_entities/BE0005561
    TargetHumans

    Receptor for platelet activating factor, a chemotactic phospholipid mediator that possesses potent inflammatory, smooth-muscle contractile and hypotensive activity.

    Polypeptides: Platelet-activating factor receptor
  2. Target

    Platelet-derived growth factor

    go.drugbank.com/bio_entities/BE0010248
    TargetHumans

    Growth factor that plays an essential role in the regulation of embryonic development, cell proliferation, cell migration, survival and chemotaxis. … Growth factor that plays an essential role in the regulation of embryonic development, cell proliferation, cell migration, survival and chemotaxis.

    Polypeptides: Platelet-derived growth factor C, Platelet-derived growth factor DSynonyms: Iris-expressed growth factor, Spinal cord-derived growth factor
  3. Target

    Fibroblast growth factor receptor

    go.drugbank.com/bio_entities/BE0010259
    TargetHumans

    Tyrosine-protein kinase that acts as a cell-surface receptor for fibroblast growth factors and plays an essential role in the regulation of embryonic development, cell proliferation, differentiation and … Tyrosine-protein kinase that acts as a cell-surface receptor for fibroblast growth factors and plays an essential role in the regulation of cell proliferation, differentiation and apoptosis.

    Polypeptides: Fibroblast growth factor receptor 1, Fibroblast growth factor receptor 2Synonyms: Keratinocyte growth factor receptor, Basic fibroblast growth factor receptor 1
  4. Target

    Tumor necrosis factor receptor

    go.drugbank.com/bio_entities/BE0010282
    TargetHumans

    Receptor for TNFSF13B/BLyS/BAFF and TNFSF13/APRIL. Promotes B-cell survival and plays a role in the regulation of humoral immunity. Activates NF-kappa-B and JNK … Transduces TRAF6- and MAP3K8-mediated signals that activate ERK in macrophages and B cells, leading to induction of immunoglobulin secretion (By similarity)

    Polypeptides: Tumor necrosis factor receptor superfamily member 10B, Tumor necrosis factor receptor superfamily member 11ASynonyms: Tumor necrosis factor receptor 1, Tumor necrosis factor receptor 2
  5. Target

    Hypoxia-inducible factor 1

    go.drugbank.com/bio_entities/BE0010297
    TargetHumans

    Also heterodimerizes with hypoxia-inducible factor alpha subunits (HIF1A, EPAS1, NPAS1 or NPAS3) to form hypoxia-inducible transcription factors that bind hypoxia response elements (HREs) and activate … Transcription factor that functions as an obligate heterodimerization partner for several basic helix-loop-helix PER-ARNT-SIM (bHLH-PAS) proteins.

    Polypeptides: Hypoxia-inducible factor 1-alphaSynonyms: Hypoxia-inducible factor 1-beta
  6. Target

    Fibroblast growth factor 23

    go.drugbank.com/bio_entities/BE0010448
    TargetHumans

    Negatively regulates osteoblast differentiation and matrix mineralization (PubMed:18282132)

    Polypeptides: Fibroblast growth factor 23Synonyms: Tumor-derived hypophosphatemia-inducing factor
  7. Target

    Opioid growth factor receptor

    go.drugbank.com/bio_entities/BE0010541
    TargetHumans

    Receptor for opioid growth factor (OGF), also known as Met-enkephalin. Seems to be involved in growth regulation

    Polypeptides: Opioid growth factor receptorFunction: opioid growth factor receptor activity
  8. Target

    Growth/differentiation factor 2

    go.drugbank.com/bio_entities/BE0010630
    TargetHumans

    Potent circulating inhibitor of angiogenesis. Signals through the type I activin receptor ACVRL1 but not other Alks. Signaling through SMAD1 in endothelial cells requires TGF-beta coreceptor endoglin/ENG

    Polypeptides: Growth/differentiation factor 2
  9. Target

    Growth/differentiation factor 11

    go.drugbank.com/bio_entities/BE0010786
    TargetHumans

    Signals through activin receptors type-2, ACVR2A and ACVR2B, and activin receptors type-1, ACVR1B, ACVR1C and TGFBR1 leading to the phosphorylation of SMAD2 and SMAD3 (PubMed:28257634) … May play critical roles in patterning both mesodermal and neural tissues (By similarity). It is required for proper vertebral patterning and orofacial development (PubMed:31215115).

    Polypeptides: Growth/differentiation factor 11
  10. Target

    Fibroblast growth factor 18

    go.drugbank.com/bio_entities/BE0011841
    TargetHumans

    Plays an important role in the regulation of cell proliferation, cell differentiation and cell migration. Required for normal ossification and bone development. … Stimulates hepatic and intestinal proliferation

    Polypeptides: Fibroblast growth factor 18Function: growth factor activity