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Islatravir
go.drugbank.com/drugs/DB15653ApprovedInvestigational[A275492] On April 21, 2026, the FDA approved the first fixed-dose combination containing islatravir (0.25 mg) and the NNRTI doravirine (100 mg), marketed as IDVYNSO, as a complete once-daily regimen for … [A275492, L56138] Chemically, it is a deoxyadenosine analogue distinguished by a 4'-ethynyl group and a 2-fluoro substitution, which collectively enhance its metabolic stability and potency.
Categories: Heterocyclic Compounds, 2-RingSynonyms: 4'-ethynyl-2-fluoro-2'-deoxyadenosinePropafenone
go.drugbank.com/drugs/DB01182ApprovedInvestigationalAn antiarrhythmia agent that is particularly effective in ventricular arrhythmias. It also has weak beta-blocking activity. The drug is generally well tolerated.
Categories: Antiarrhythmics, Class I, P-glycoprotein inhibitorsSynonyms: 1-(2-(2-hydroxy-3-(propylamino)propoxy)phenyl)-3-phenyl-1-propanone, 2-(2'-hydroxy-3'-propylaminopropoxy)-ω-phenylpropiophenoneCinchocaine
go.drugbank.com/drugs/DB00527ApprovedVet approvedA local anesthetic of the amide type now generally used for surface anesthesia.
Mixtures: ULTRAPROCT %0,09+%0,09+%0,5 MERHEM, 10 G, Dibucaine HCl 0.5% / Lidocaine 15% / Phenylephrine HCl 1% / Prilocaine 5%Categories: Heterocyclic Compounds, 2-RingBisoprolol
go.drugbank.com/drugs/DB00612ApprovedInvestigational[A180472,L7219] It is considered a potent drug with a long-half life that can be used once daily to reduce the need for multiple doses of antihypertensive drugs. … Bisoprolol is a cardioselective β1-adrenergic blocking agent used to treat high blood pressure.
Mixtures: SOPRANO 10 MG/25 MG FILM TABLET, 50 ADET, SOPRANO 10 MG/25 MG FILM TABLET, 30 ADETCategories: P-glycoprotein inhibitors, P-glycoprotein substratesPropiomazine
go.drugbank.com/drugs/DB00777ApprovedStructurally and pharmacologically similar to clozapine, propiomazine binds to alpha(1), dopamine, histamine H1, muscarinic, and serotonin type 2 (5-HT2) receptors.
Categories: Heterocyclic Compounds, 3-Ring, Adrenergic alpha-1 Receptor AntagonistsSynonyms: 10-(2-Dimethylaminopropyl)-2-propionylphenothiazine, 2-Propionyl-10-(2-(dimethylamino)propyl)phenothiazineClemastine
go.drugbank.com/drugs/DB00283ApprovedInvestigationalAn ethanolamine-derivative, first generation histamine H1 antagonist used in hay fever, rhinitis, allergic skin conditions, and pruritus. It causes drowsiness.
Mixtures: Tavist-D TabletsCategories: Heterocyclic Compounds, 1-Ring, Cytochrome P-450 CYP2D6 InhibitorsViloxazine
go.drugbank.com/drugs/DB09185ApprovedInvestigationalWithdrawnViloxazine is a selective norepinephrine reuptake inhibitor.[L41685] For decades, an immediate-release formulation of viloxazine has been used in Europe as an antidepressant.
Categories: MATE 1 Inhibitors, Histamine H2 AntagonistsSynonyms: 2-((2-Ethoxyphenoxy)methyl)morpholineNicorandil
go.drugbank.com/drugs/DB09220ApprovedInvestigationalWithdrawnIt is a niacinamide derivative that induces vasodilation of arterioles and large coronary arteries by activating potassium channels. … Nicorandil is a dual-action potassium channel opener that relaxes vascular smooth muscle through membrane hyperpolarization via increased transmembrane potassium conductance and increased intracellular
Categories: Heterocyclic Compounds, 1-RingSynonyms: N-(2-Hydroxyethyl)nicotinamide nitrate, 2-Nicotinamidoethyl nitrateMebutamate
go.drugbank.com/drugs/DB06797ApprovedMebutamate is a sedative and anxiolytic drug with anti-hypertensive (blood pressure lowering) effects comparable to those of other barbiturates but is only around 1/3rd the potency of secobarbital as a
Synonyms: 2-Methyl-2-sec-butyl-1,3-propanediol dicarbamate, 2-sec-Butyl-2-methyl-1,3-propanediol dicarbamateAtenolol
go.drugbank.com/drugs/DB00335ApprovedInvestigationalAtenolol is a cardioselective beta-blocker used in a variety of cardiovascular conditions. … [A235850,A235855] A Cochrane review of patients being treated for primary hypertension shows that atenolol shows a risk ratio of 0.88 for cardiovascular disease risk and a risk ratio of 0.99 for mortality
Mixtures: TENORETIC 100 MG/25 MG FILM TABLET, 28 ADET, TENORETIC 50 MG/12.5 MG FILM TABLET, 28 ADETCategories: Cytochrome P-450 Substrates, Adrenergic beta-1 Receptor Antagonists