DB00797ApprovedVet approvedWithdrawnSmall molecule
Tolazoline is a vasodilator used to treat pulmonary artery anomalies. A vasodilator that apparently has direct actions on blood vessels and also increases cardiac output.
- Mechanism
- Curator reviewed
Vasodilation by means of a direct effect on peripheral vascular smooth muscle and indirect effects produced, in part, by release of endogenous histamine; tolazoline has moderate alpha-adrenergic blocking activity and has histamine agonist activity. Tolazoline usually reduces pulmonary arterial pressure and vascular resistance.
- Primary indication
- For the treatment of pulmonary artery anomaliesCurator reviewed
- Formula / weight
- C10H12N2 · 160.2157 g/mol (avg)
- First approval
- United States, 1948
- Also known as
- 2-Benzylimidazoline · Benzazoline
- Code names
- Ciba 3259
Resolves to
Clinical / RWD
Structure
InChIKey
JIVZKJJQOZQXQB-UHFFFAOYSA-NSMILESC(C1=NCCN1)C1=CC=CC=C1What you can answer from here — as of September 23, 2026
8Protein targetsEach mapped to UniProt, with action and pharmacological actionListed above
Which drugs share a target with Tolazoline, and which of those have an active Phase 3 trial?
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