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Displaying results 1001 - 1010 of 10000 in total
  1. Drug

    Deutivacaftor

    go.drugbank.com/drugs/DB15141
    ApprovedInvestigational

    Deutivacaftor is a small molecule cystic fibrosis transmembrane conductance regulator (CFTR) potentiator. … It is used alongside CFTR correctors to increase the quantity and function of CFTR at the cell surface in patients with cystic fibrosis.

    Categories: Cytochrome P-450 CYP2C8 Inhibitors, Cytochrome P-450 CYP2C9 Inhibitors
  2. Drug

    Nisevokitug

    go.drugbank.com/drugs/DB17561
    Investigational

    Nisevokitug is a monoclonal antibody targeted against transforming growth factor beta (TGFβ) under investigation in NCT04097821 (A Randomized, Open-label, Phase I/II Open Platform Study Evaluating Safety

  3. Pathway

    Formoterol Action Pathway

    smpdb.ca/view/SMP0126086
    Drug action

    Formoterol is a long acting beta-2 adrenergic receptor agonist that is used as a bronchodilator and to manage asthma and COPD. It can be used as well for prophylaxis against exercise induced bronchospasm. This drug is inhaled and can be ...

    Drugs: ATP · Formoterol · Potassium cation · Calcium · Magnesium cation · Cyclic adenosine monophosphate
    Enzymes: Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12
  4. Pathway

    Arformoterol Action Pathway

    smpdb.ca/view/SMP0126088
    Drug action

    Arformoterol is a beta-2 adrenergic receptor agonist that is used as a bronchodilator to treat COPD and chronic bronchitis. It accomplishes this by upon inhalation of the drug by relaxing smooth muscles in the airways to improve breathin...

    Drugs: ATP · Arformoterol · Potassium cation · Calcium · Magnesium cation · Cyclic adenosine monophosphate
    Enzymes: Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12
  5. Pathway

    Olodaterol Action Pathway

    smpdb.ca/view/SMP0126091
    Drug action

    Olodaterol is a beta-2 adrenergic agonist that is long acting. It is used for the management of chronic bronchitis and COPD, but not asthma. It accomplishes this by mediating smooth muscle relaxation and bronchodilator via L-type calcium...

    Drugs: ATP · Potassium cation · Calcium · Magnesium cation · Cyclic adenosine monophosphate · Olodaterol
    Enzymes: Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12
  6. Pathway

    Terbutaline Action Pathway

    smpdb.ca/view/SMP0126093
    Drug action

    Terbutaline is a beta-2 adrenergic receptor agonist that is used primarily as a bronchodilator. It can be found under the brand name Bricanyl and is an inhaled drug with a short duration. It is used for the prevention and reversal of bro...

    Drugs: ATP · Terbutaline · Potassium cation · Calcium · Magnesium cation · Cyclic adenosine monophosphate
    Enzymes: Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12
  7. Pathway

    Procaterol Action Pathway

    smpdb.ca/view/SMP0126094
    Drug action

    Procaterol is a beta-2 adrenergic agonist that is used as a bronchodilator. It is a long acting and potent drug that can be taken orally or through inhalation for the treatment of asthma and COPD. The purpose of this drug is to increase ...

    Drugs: ATP · Potassium cation · Procaterol · Calcium · Magnesium cation · Cyclic adenosine monophosphate
    Enzymes: Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12
  8. Pathway

    Mirabegron Action Pathway

    smpdb.ca/view/SMP0126105
    Drug action

    Mirabegron is a beta-3 adrenergic receptor agonist that is used to treat overactive bladder and neurogenic detrusor activity. It relaxes the smooth muscle of the bladder which expands the bladder to relieve urgency. It is an oral medicat...

    Drugs: ATP · Potassium cation · Calcium · Magnesium cation · Cyclic adenosine monophosphate · Mirabegron
    Enzymes: Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12
  9. Pathway

    Gs Histaminic Smooth Muscle Relaxation

    smpdb.ca/view/SMP0126967
    Physiological

    The Gs alpha subunit (Gαs, Gsα) is a subunit of the heterotrimeric G protein Gs that stimulates the cAMP-dependent pathway by activating adenylyl cyclase. Gsα is a GTPase that functions as a cellular signaling protein. Gsα is the foundin...

    Drugs: ATP · Potassium cation · Calcium · Magnesium cation · Cyclic adenosine monophosphate
    Enzymes: Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(s) subunit alpha isoforms short
  10. Pathway

    Celiprolol B2-Adrenergic Vasodilation Action Pathway

    smpdb.ca/view/SMP0126095
    Drug action

    Celiprolol is a selective beta-1 adrenergic receptor antagonist and a beta-2 adrenergic receptor partial agonist that is used for the management of hypertension and angina pectoris. The beta-2 adrenergic receptor agonist activity is attr...

    Drugs: ATP · Potassium cation · Calcium · Magnesium cation · Cyclic adenosine monophosphate · Celiprolol
    Enzymes: Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12