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Cefoperazone
go.drugbank.com/drugs/DB01329ApprovedInvestigationalWithdrawnWhile its clinical use has been discontinued in the U.S., cefoperazone is available in several European countries most commonly under the product name, Sulperazon. … Cefoperazone is a semisynthetic broad-spectrum cephalosporin proposed to be effective against <i>Pseudomonas</i> infections.
Dextrothyroxine
go.drugbank.com/drugs/DB00509ApprovedWithdrawnThe major hormone derived from the thyroid gland. Thyroxine is synthesized via the iodination of tyrosines (monoiodotyrosine) and the coupling of iodotyrosines (diiodotyrosine) in the thyroglobulin. … Thyroxine is released from thyroglobulin by proteolysis and secreted into the blood.
Mirikizumab
go.drugbank.com/drugs/DB14910ApprovedInvestigational[L46237] In April 2023, the US FDA declined to approve mirikizumab for the treatment of ulcerative colitis on the basis of manufacturing concerns. … It inhibits the actions of interleukin-23 (IL-23), a pro-inflammatory cytokine that activates pathways contributing to the development of inflammatory diseases.
Tetracosactide
go.drugbank.com/drugs/DB01284ApprovedInvestigationalTetracosactide exhibits the same activity as natural ACTH with regard to all its biological activities. … Tetracosactide (also known as Cosyntropin) is a synthetic peptide that is identical to the 24-amino acid segment (sequence: SYSMEHFRWGKPVGKKRRPVKVYP) at the N-terminal of adrenocorticotropic hormone.
Uridine triacetate
go.drugbank.com/drugs/DB09144ApprovedAdditionally, orotic acid from the de novo pyrimidine pathway that cannot be converted to UMP is excreted in the urine, accounting for the common name of the disorder, orotic aciduria. … It is provided in the prodrug form as uridine triacetate as this form delivers 4- to 6-fold more uridine into the systemic circulation compared to equimolar doses of uridine itself.
Difelikefalin
go.drugbank.com/drugs/DB11938ApprovedInvestigational[A237610] Further investigations revealed that dynorphins, endogenous agonists of KORs, work to inhibit the itching sensation at the spinal cord level, and scratching could be elicited in mouse models … [L36420,L36395] Difelikefalin was later approved by the EMA in April 2022 for the same indication.[L41665]
Tozinameran
go.drugbank.com/drugs/DB15696ApprovedInvestigational[L26966,L26976] In November 2021, Health Canada [L39115] and the EMA [L39272] approved the vaccine to be administered as a booster dose approximately six months after the second dose. … [L36025] Currently, sufficient data are not available to determine the longevity of protection against COVID-19, nor direct evidence that the vaccine prevents the transmission of the SARS-CoV-2 virus
Meradimate
go.drugbank.com/drugs/DB11096Approved[T200] It is currently required to be named as meradimate in all FDA approved OTC products. Meradimate is approved by the FDA and Health Canada to be used as an ingredient in sunblocking products.
Acetyl sulfisoxazole
go.drugbank.com/drugs/DB14033ApprovedVet approvedSulfisoxazole acetyl competes with PABA for the bacterial enzyme, _dihydropteroate synthase_, preventing the incorporation of PABA into dihydrofolic acid, which is the precursor of folic acid. … It is often combined with erythromycin to treat acute otitis media caused by the bacteria, haemophilus influenzae [L2790].
Verapamil
go.drugbank.com/drugs/DB00661ApprovedInvestigationalVerapamil is a phenylalkylamine calcium channel blocker used in the treatment of high blood pressure, heart arrhythmias, and angina,[L8791] and was the first calcium channel antagonist to be introduced … into therapy in the early 1960s.
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