Tetracosactide

DB01284ApprovedInvestigationalSmall moleculeAdrenocorticotropic Hormone

Tetracosactide is a diagnostic agent used in the screening of patients presumed to have adrenocortical insufficiency. Tetracosactide (also known as Cosyntropin) is a synthetic peptide that is identical to the 24-amino acid segment (sequence: SYSMEHFRWGKPVGKKRRPVKVYP) at the N-terminal of adrenocorticotropic hormone.

Mechanism: Cosyntropin combines with a specific receptor in the adrenal cell plasma membrane and, in patients with normal adrenocortical function, stimulates the initial reaction involved in the synthesis of adrenal steroids (including cortisol, cortisone, weak androgenic substances, and a limited quantity of aldosterone) from cholesterol by increasing the quantity of the substrate within the mitochondria. Cosyntropin does not significantly increase plasma cortisol concentration in patients with primary or secondary adrenocortical insufficiency.
Curator reviewed
Primary indication: For use as a diagnostic agent in the screening of patients presumed to have adrenocortical insufficiency.Curator reviewed · 26 structured indications
Formula / weight: C₁₃₆H₂₁₀N₄₀O₃₁S · 2933.49 g/mol (avg)
First approval: Canada, 2004 · United States, 2003
Also known as: ATCH (1-24) · beta(1-24)-corticotrophin · Corticotropin tetracosapeptide · corticotropin-(1-24) · Cosyntropin
Brand names: Cortrosyn
Synacthen

Resolves to

Compound

UNII72YY86EA29CAS16960-16-0ChEMBLCHEMBL2103784ChEBI3901PubChem60210072KEGGD00284

Clinical / RWD

RxNorm2890ATCH01AA02PharmGKBPA164749052

Structure

InChIKeyZOEFCCMDUURGSE-SQKVDDBVSA-NSMILES

CSCC[C@H](NC(=O)[C@H](CO)NC(=O)[C@H](CC1=CC=C(O)C=C1)NC(=O)[C@@H](N)CO)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC1=CN=CN1)C(=O)N[C@@H](CC1=CC=CC=C1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC1=CNC2=C1C=CC=C2)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C(C)C)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC1=CC=C(O)C=C1)C(=O)N1CCC[C@H]1C(O)=O

Targets

Q01718MC2R

What you can answer from here — as of September 23, 2026

1Protein targetEach mapped to UniProt, with action and pharmacological action

Listed above

86Drug interactionsStructured to mechanism, not free text

30Clinical trialsPhase, status and sponsor resolved per trial

26Structured indicationsCondition, population, route and combination as fields, not prose

12ContraindicationsEach with its own population and attribute set

19Marketed productsAcross 5 countries and 12 labellers

1ATC codeIncluding every combination product, plus 19 drug categories

5+ReferencesStructured and connected to the statements they support

Which drugs share a target with Tetracosactide, and which of those have an active Phase 3 trial?

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