Sulfisoxazole acetyl is an ester of sulfisoxazole, a broad-spectrum sulfanilamide and a synthetic analog of para-aminobenzoic acid (PABA) with antibacterial activity. Sulfisoxazole acetyl competes with PABA for the bacterial enzyme,... This process causes an inhibition of bacterial folic acid synthesis and de novo synthesis of purines and pyrimidines, resulting in cell growth arrest and cell death.
- Mechanism
- Curator reviewed · 1 reference
Sulfisoxazole is a competitive inhibitor of the enzyme dihydropteroate synthetase. It inhibits bacterial synthesis of dihydrofolic acid by preventing the condensation of the pteridine with para-aminobenzoic acid (PABA), a substrate of the enzyme dihydropteroate synthetase. The inhibited reaction is necessary in these organisms for the synthesis of folic acid.
- Primary indication
- Acute, recurrent or chronic urinary tract infections (primarily pyelonephritis, pyelitis and cystitis) due to susceptible organisms (usually Escherichia coli, Klebsiella-Enterobacter, staphylococcus, Proteus mirabilis and, less frequently, Proteus vulgaris) in the absence of obstructive uropathy or...Curator reviewed · 13 structured indications
- Formula / weight
- C13H15N3O4S · 309.34 g/mol (avg)
- First approval
- Canada, 2009 · United States, 1953
- Also known as
- Acetylsulfisoxazole · Sulfisoxazole acetyl
Resolves to
JFNWFXVFBDDWCX-UHFFFAOYSA-NSMILESCC(=O)N(C1=C(C)C(C)=NO1)S(=O)(=O)C1=CC=C(N)C=C1What you can answer from here — as of October 22, 2025
Which drugs share a target with Acetyl sulfisoxazole, and which of those have an active Phase 3 trial?
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