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Oxymetholone
go.drugbank.com/drugs/DB06412ApprovedIllicitOxymetholone is a synthetic anabolic steroid marketed under the brand name Anapolon by Hoffmann La Roche Limitedand used in the treatment of osteoporosis, anaemia, and as an agent to stimulate muscle growth … In 2009, no producers of oxymetholone were identified worldwide (SRI 2009), but it was available from 14 suppliers, including 8 U.S. suppliers (ChemSources 2009).
Categories: Cytochrome P-450 CYP2D6 Inhibitors, Cytochrome P-450 CYP3A InhibitorsSynonyms: 17β-Hydroxy-2-hydroxymethylidene-17α-methyl-3-androstanoneTacrolimus
go.drugbank.com/drugs/DB00864ApprovedInvestigationalThis FKBP12-FK506 complex inhibits calcineurin which inhibits T-lymphocyte signal transduction and IL-2 transcription. … It is also used in a topical preparation in the treatment of severe atopic dermatitis, severe refractory uveitis after bone marrow transplants, and the skin condition vitiligo.
Mixtures: Hyaluronic Acid Sodium Salt 1% / Tacrolimus 0.1% / Urea 20%, Hyaluronic Acid Sodium Salt 1% / Niacinamide 4% / Tacrolimus 0.1%Categories: P-glycoprotein substrates with a Narrow Therapeutic Index, Cytochrome P-450 CYP3A4 Substrates with a Narrow Therapeutic IndexEculizumab
go.drugbank.com/drugs/DB01257ApprovedInvestigationalEculizumab is a monoclonal antibody that targets complement protein C5. … [L6919] In Q1 2023, the EMA's Committee for Medicinal Products for Human Use (CHMP) adopted a positive opinion of two formulations of eculizumab indicated for the treatment of paroxysmal nocturnal hemoglobinuria
Categories: Complement C5 inhibitorsProducts: Bekemv 300 mg/30 mL İnfüzyonluk Çözelti Hazırlamak İçin Konsantre, 1 ADET, ELİZARİA 300 MG/30 ML İNFÜZYONLUK ÇÖZELTİ HAZIRLAMAK İÇİN KONSANTRE, 1 ADETCapecitabine
go.drugbank.com/drugs/DB01101ApprovedInvestigationalCapecitabine is a prodrug, that is enzymatically converted to fluorouracil (antimetabolite) in the tumor, where it inhibits DNA synthesis and slows growth of tumor tissue. … Capecitabine is an orally-administered chemotherapeutic agent used in the treatment of metastatic breast and colorectal cancers.
Categories: Cytochrome P-450 CYP2C9 Substrates with a Narrow Therapeutic Index, Cytochrome P-450 SubstratesSynonyms: pentyl 1-(5-deoxy-β-D-ribofuranosyl)-5-fluoro-1,2-dihydro-2-oxo-4-pyrimidinecarbamate, Pentyl [1-(5-deoxy-β-D-ribofuranosyl)-5-fluoro-2-oxo-1,2-dihydropyrimidin-4-yl]carbamatePitavastatin
go.drugbank.com/drugs/DB08860ApprovedInvestigational[A181087, A181406] Evidence has shown that even for low-risk individuals (with <10% risk of a major vascular event occurring within 5 years) statins cause a 20%-22% relative reduction in major cardiovascular … More specifically, statin medications competitively inhibit the enzyme hydroxymethylglutaryl-coenzyme A (HMG-CoA) Reductase,[A181421] which catalyzes the conversion of HMG-CoA to mevalonic acid.
Categories: Heterocyclic Compounds, 2-Ring, Cytochrome P-450 SubstratesProducts: Trolise 2 mg Filmtabletten, LIVALO (TABLET 2 MG)Human thrombin
go.drugbank.com/drugs/DB11571ApprovedInvestigationalIn particular, while human thrombin products are made from pooled human source plasma, recombinant thrombin is a human coagulation protein produced via recombinant DNA technology from a genetically modified … Human thrombin is a sterile solution, pH 6.8-7.2, containing highly purified human thrombin for the activation of clotting.
Mixtures: EVICEL Fibrin Sealant (Human) Solution, 50-90 mg/ml, 800-1200 IU/ml, EVICEL® SELLANTE DE FIBRINA HUMANAProducts: THROMBIRAAS1000 UIMeropenem
go.drugbank.com/drugs/DB00760ApprovedInvestigationalIn August 2017, a combination antibacterial therapy under the market name vabomere was approved for treatment of adult patients with complicated urinary tract infections (cUTI). … Meropenem is a broad-spectrum carbapenem antibiotic. It is active against Gram-positive and Gram-negative bacteria.
Categories: Heterocyclic Compounds, 2-RingSynonyms: (4R,5S,6S)-3-{[(3S,5S)-5-(dimethylcarbamoyl)pyrrolidin-3-yl]thio}-6-[(1R)-1-hydroxyethyl]-4-methyl-7-oxo-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylic acidClorazepic acid
go.drugbank.com/drugs/DB00628ApprovedIllicitIn September 2020, a black box warning describing these risks was included on the product label of benzodiazepines as per FDA regulation. … Clorazepic acid (clorazepate) is a water-soluble benzodiazepine with muscle-relaxant and anticonvulsant actions effective in the treatment of anxiety.
Categories: Heterocyclic Compounds, 2-Ring, Cytochrome P-450 SubstratesSynonyms: 7-chloro-2,3-dihydro-2,2-dihydroxy-5-phenyl-1H-1,4-benzodiazepine-3-carboxylic acidTelbivudine
go.drugbank.com/drugs/DB01265ApprovedWithdrawnTelbivudine is a synthetic thymidine nucleoside analog with specific activity against the hepatitis B virus.
Categories: Heterocyclic Compounds, 1-Ring, Hepatitis B Virus Nucleoside Analog Reverse Transcriptase InhibitorSynonyms: 1-(2-deoxy-β-L-ribofuranosyl)-5-methyluracil, 2'-Deoxy-L-thymidineTretinoin
go.drugbank.com/drugs/DB00755ApprovedInvestigationalNutraceutical[A257474] It is an oxidation product in the physiological pathway of vitamin A metabolism. … [A257689] In human circulation, tretinoin is normally found at very low concentrations, approximately 4 to 14 nmol/L.
Synonyms: Tretin M, (all-E)-3,7-Dimethyl-9-(2,6,6-trimethyl-1-cyclohexen-1-yl)-2,4,6,8-nonatetraenoic acidInternational brands: Stieva-A