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Levonorgestrel Action Pathway
smpdb.ca/view/SMP0125332Drug actionLevonorgestrel (LNG) is a progestin (synthetic progestogen) found in contraceptives (birth control) that are taken orally, in subdermal implants or in intrauterine devices (IUD). Oral contraceptives and IUDs have a low dose, while emerge...
Enzymes: Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12Protamine sulfate
go.drugbank.com/drugs/DB09141ApprovedInvestigationalSince it's earliest discovery in salmon rine sperm heads in the late 1800's to its formal introduction via US FDA approval in 1939, protamine sulfate has occupied an important therapeutic niche as perhaps … As a consequence, whenever protamine sulfate use is clinically considered, careful consideration must be given as to whether the use of the agent could decrease the safety of the procedure or worsen the
Products: PROLFAT 50 MG/5 ML IV ENJEKSİYONLUK ÇÖZELTİ, 1 ADET, PAMINTU 10 MG/ML ENJEKSIYONLUK ÇÖZELTI IÇEREN FLAKON,5 ML 1 ADETOpium
go.drugbank.com/drugs/DB11130ApprovedIllicitDuring the years, opium was used as a sedative and hypnotic, but it was determined to be addictive.[A32171] Opium is extracted from _Papaver somniferum_, which is more known as poppies. … Opium is the first substance of the diverse group of the opiates. It has been known for a long time, and the first evidence of a poppy culture dates from 5 thousand years by the Sumerians.
Categories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP3A SubstratesMeperidine
go.drugbank.com/drugs/DB00454ApprovedInvestigationalA narcotic analgesic that can be used for the relief of most types of moderate to severe pain, including postoperative pain and the pain of labor.
Categories: P-glycoprotein substrates, Cytochrome P-450 SubstratesProducts: Demerol 10%-liq Im IV Sc, Demerol 10%-liq Im Sc 100mg/mlLumacaftor
go.drugbank.com/drugs/DB09280ApprovedInvestigational[A18395] The next most common mutation, G551D, affecting 4-5% of CF patients worldwide, is characterized as a missense mutation, whereby there is sufficient amount of protein at the cell surface, but opening … Lumacaftor is a drug used in combination with [DB08820] as the fixed dose combination product Orkambi for the management of Cystic Fibrosis (CF) in patients aged 6 years and older.
Categories: Cytochrome P-450 CYP2B6 Inducers, P-glycoprotein inducersSynonyms: 3-(6-{[1-(2,2-difluoro-2H-1,3-benzodioxol-5-yl)cyclopropane-1-carbonyl]amino}-3-methylpyridin-2-yl)benzoic acidLatanoprost
go.drugbank.com/drugs/DB00654ApprovedInvestigationalAnother benefit latanoprost is that it can be administered once a day.[A184490] … Latanoprost is a prodrug analog of prostaglandin F2 alpha that is used to treat elevated intraocular pressure (IOP). It was initially approved by the FDA in 1998.
Mixtures: OFTIDON® T SOLUCION OFTALMICA, LATROST-T %0,005+%0,5 GÖZ DAMLASI, ÇÖZELTİ, 2,5 ML 1 ŞİŞECategories: Prostaglandins F, Synthetic, Compounds used in a research, industrial, or household settingNisevokitug
go.drugbank.com/drugs/DB17561InvestigationalNisevokitug is a monoclonal antibody targeted against transforming growth factor beta (TGFβ) under investigation in NCT04097821 (A Randomized, Open-label, Phase I/II Open Platform Study Evaluating Safety
U-0126
go.drugbank.com/drugs/DB17060ExperimentalU-0126 is a direct inhibitor of the mitogen-activated protein-kinase kinase family members, MEK-1 and MEK-2.[A253162]
Salts: U-0126-EtOHSynonyms: 1,4-diamino-2,3-dicyano-1,4-bis(2-aminophenylthio)butadiene, Butanedinitrile, bis(amino((2-aminophenyl)thio)methylene)-, (2z,3z)-Levetiracetam
go.drugbank.com/drugs/DB01202ApprovedInvestigationalLevetiracetam is a drug within the pyrrolidine class that is used to treat various types of seizures stemming from epileptic disorders. … make it a desirable choice over other AEDs, a class of drugs notorious for having generally narrow therapeutic indexes and a propensity for involvement in drug interactions.
Categories: P-glycoprotein substrates, Heterocyclic Compounds, 1-RingProducts: TAMLET-S, LEVETIRACETAM DOC GENERICI