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Alpelisib
go.drugbank.com/drugs/DB12015ApprovedInvestigationalAlpelisib was designed to target this enzyme that appears to be mutated at a rate of nearly 30% in human cancers, leading to hyperactivation. … To initiate alpelisib therapy, it is required that the presence of a PIK3CA mutation in the tissue and/or liquid biopsy sample collection should be confirmed via FDA-approved diagnostic tests.
Butenafine
go.drugbank.com/drugs/DB01091ApprovedIn particular, butenafine acts to inhibit the activity of the squalene epoxidase enzyme that is essential in the formation of sterols necessary for fungal cell membranes. … Butenafine's mechanism of action is believed to involve the synthesis inhibition of sterols.
Dexbrompheniramine
go.drugbank.com/drugs/DB00405ApprovedDexbrompheniramine maleate is an antihistamine agent that is used for the treatment of allergic conditions, such as hay fever or urticaria.
Mixtures: Alahist PE, Ala-hist PEEluxadoline
go.drugbank.com/drugs/DB09272ApprovedInvestigationalThe mu-, kappa-, and delta-opioid receptors mediate endogenous and exogenous opioid response in the central nervous system and peripherally in the gastrointestinal system. … of abdominal pain and reductions in the Bristol Stool Scale.
Categories: Serotonergic Drugs Shown to Increase Risk of Serotonin SyndromeSotagliflozin
go.drugbank.com/drugs/DB12713ApprovedInvestigational[L39734] A similar approval has also been sought in the US, but the FDA has since published a proposal to refuse the approval because the data submitted did not show that it was safe under the proposed … [L39739] On March 22, 2022, the marketing authorization of sotagliflozin for the treatment of type 1 diabetes mellitus was withdrawn by the EMA due to commercial reasons.
Naratriptan
go.drugbank.com/drugs/DB00952ApprovedNaratriptan is a triptan drug that is selective for the 5-hydroxytryptamine1 receptor subtype. It is typically used for the treatment of migraine headaches.
Categories: Serotonergic Drugs Shown to Increase Risk of Serotonin SyndromePhenytoin
go.drugbank.com/drugs/DB00252ApprovedInvestigationalVet approved[A188826,A188832] Clinicians are advised to initiate therapeutic drug monitoring in patients who require phenytoin since even small deviations from the recommended therapeutic range can lead to suboptimal … [A189219,A35884] Both parenteral and oral formulations of phenytoin are available on the market.[A189219]
Products: FENIFFLER-T, EPAMIN ® XR 100 MG CÁPSULAS DE LIBERACIÓN PROLONGADACefepime
go.drugbank.com/drugs/DB01413ApprovedInvestigational[A249050] The popularity of its third-generation predecessors, its clinical efficacy, and the high prevalence of multidrug-resistant bacteria might be some of the factors leading to an increase in the … The activity of cefepime against Enterobacteriaceae, _Pseudomonas aeruginosa_, and _Staphylococcus aureus_ is due to its high stability toward beta-lactamases.
Products: ROXIPIME 2 G IV ENJEKSIYON VE INFÜZYON IÇIN TOZ IÇEREN FLAKON ,1 ADET, ROXIPIME 2 G IV ENJEKSIYON VE INFÜZYON IÇIN TOZ IÇEREN FLAKON ,10 ADETTannic acid
go.drugbank.com/drugs/DB09372ApprovedInvestigationalIt is a type of the commercially available tannins. It acts as a weak acid. … In the old days it was used as antidote against different poisons. Nowadays, tannic acid is applied topically for the treatment of cold sores, diaper rash, fever blisters and poison ivy.
Mixtures: Extrait De FraisesUbrogepant
go.drugbank.com/drugs/DB15328ApprovedInvestigationalto its predecessors. … [A189207,A189213] Previous agents within this class were efficacious but limited by liver toxicity - this led to the development of ubrogepant, which was designed to be a hepatoxicity-free alternative