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Tenecteplase Action Pathway
smpdb.ca/view/SMP0000283Drug actionIt is also activated through plasma prekallikrein and coagulation factor XIIa which activate plasma kallikrein, which then pairs with coagulation factor XII simultaneously with the previous collagen chain … This enzyme also catalyzes precursors of prothrombin and coagulation factors VII, IX and X to prothrombin, and coagulation factors VII, IX and X.
Enzymes: Collagen alpha-1(I) chainCoagulation
smpdb.ca/view/SMP0130473PhysiologicalThe intrinsic pathway is activated by trauma inside vasculature and is activated by platelets, exposed endothelium and collagen. … Exposed collagen from broken vessels binds to factor XII activating it to XIIa which converts prekallikrein and factor XI to kallikrein and factor XIa respectively.
Enzymes: Collagen alpha-1(I) chainBivalirudin.
smpdb.ca/view/SMP0000277Drug actionIt binds circulating and clot-bound thrombin at the catalytic site and the anion binding exosite. … This destabilizes the thrombus and inhibits the promotion of thrombin production and platelet activation. As a result, bivalirudin prevents or reduces clot formation.
Enzymes: Collagen alpha-1(I) chainLepirudin Action Pathway
smpdb.ca/view/SMP0000278Drug actionLepirudin can also reduce thrombocytopenia and break up clot. … Lepirudin (also known as Refludan) is an anticoagulant that can be used for inhibiting thrombin (prothrombin) irreversibly. Binding of thrombin can prevent formation of clot as well as thrombus.
Enzymes: Collagen alpha-1(I) chainAlteplase Action Pathway
smpdb.ca/view/SMP0000280Drug actionAlteplase is the generic version of the drugs Activase and Actilyse. It is a thrombolytic drug prescribed to treat acute myocardial infarctions and other blood clotting conditions. … A side effect of the drug is bleeding, angioedema, allergic reactions and fever.
Enzymes: Collagen alpha-1(I) chainAnistreplase Action Pathway
smpdb.ca/view/SMP0000281Drug actionPlasmin breaks down the fibrin of the thrombus to break up the clot and release arterial blockages. … The drug is an acylated streptokinase-plasminogen complex. The acylation of the drug renders it temporarily inactive, protecting it from plasmin inhibitors.
Enzymes: Collagen alpha-1(I) chainAprotinin Action Pathway
smpdb.ca/view/SMP0000288Drug actionAprotinin, trade name Trasylol is a bovine serine protease inhibitor of trypsin, chymotrypsin, kallikrein and plasmin. … The inhibition of kallikrein inhibits factor XIIa production to reduce fibrinolysis and coagulation. Inhibition of plasmin slows down fibrinolysis.
Enzymes: Collagen alpha-1(I) chainWarfarin Action Pathway
smpdb.ca/view/SMP0000268Drug actionIt is also activated through plasma prekallikrein and coagulation factor XIIa which activate plasma kallikrein, which then pairs with coagulation factor XII simultaneously with the previous collagen chain … The enzyme vitamin K-dependent gamma carboxylase catalyzes precursors of prothrombin and coagulation factors VII, IX and X to prothrombin, and coagulation factors VII, IX and X.
Enzymes: Collagen alpha-1(I) chainArgatroban.
smpdb.ca/view/SMP0000276Drug actionDirect thrombin inhibitors bind plasma and fibrin bound thrombin independently of co-factor antithrombin.The inhibition of thrombin reduces the stability of the clot and promotes clot break down. … Argatroban does not effect serine proteases like, trypsin, factor Xa, plasmin, and kallikrein.
Enzymes: Collagen alpha-1(I) chainAminocaproic Acid Action Pathway
smpdb.ca/view/SMP0000286Drug actionThis blockade inhibits plasminogen binding to fibrin and the conversion of plasminogen to plasmin. These prevents fibrin degradation and maintains the stability of fibrin clots. … Aminocaproic acid, brand name Amicar, is a derivate of lysine and is an antifibrinolytic drug. Antifibrinolytics drugs are commonly used during major surgery to prevent significant blood loss.
Enzymes: Collagen alpha-1(I) chain