Search

Displaying results 101 - 110 of 134474 in total
  1. Pathway

    Icosapent Prostaglandin G/H synthase 1 and 2 anti-inflammatory Action Pathway

    smpdb.ca/view/SMP0126557
    Drug action

    This molecule also inhibits the arachidonic acid conversion into the thromboxane-2 and prostaglandin-2 families because it inhibits the prostaglandin G/H synthase 1 and 2 (COX-1 and COX-2). … Then icosapent shows anti-atherogenic and anti-thrombotic effects in cells. EPA serves as a substrate for Prostaglandin-endoperoxide synthase 1 and 2.

    Drugs: Glutathione · Icosapent · Dinoprostone · Calcium · Mesoheme · Prostaglandin G2 +1 more
  2. Pathway

    Fish oil Prostaglandin G/H synthase 1 and 2 anti-inflammatory Action Pathway

    smpdb.ca/view/SMP0126563
    Drug action

    EPA and DHA do competition with arachidonic acids for both COX-1 and COX-2 enzymes. … These are responsible for the conversion of arachidonic acid (an omega-6 fatty acid) into prostaglandins and thromboxanes, which are important mediators of inflammation and pain.

    Drugs: Glutathione · Icosapent · Dinoprostone · Calcium · Mesoheme · Prostaglandin G2 +1 more
  3. Pathway

    Edoxaban Action Pathway

    smpdb.ca/view/SMP0126436
    Drug action

    It selectively inhibits factor Xa so the cleavage of prothrombin to thrombin is inhibited. … Due to the anticoagulant properties herbs and supplements with anticoagulant and antiplatelet activity should be avoided this includes garlic, ginger, bilberry, danshen, piracetam and ginkgo biloba.

    Drugs: Calcium
    Enzymes: Coagulation factor IX, Coagulation factor VIII
  4. Pathway

    Bivalirudin Action Pathway

    smpdb.ca/view/SMP0126441
    Drug action

    It binds reversibly to the active site of thrombin inhibiting its activation of fibrinogen and coagulation factor XIII. … Inactivation of coagulation factor XIII further inhibits blood clot formation, as this factor is responsible for stabilizing cross-linking fibrin creating the meshwork for the clot.

    Drugs: Bivalirudin · Calcium
    Enzymes: Coagulation factor IX, Coagulation factor VIII
  5. Pathway

    Aprotinin Plasminogen Antifibrinolytic Action Pathway

    smpdb.ca/view/SMP0126443
    Drug action

    The drug is slowly metabolized by lysosomal enzymes and is eliminated through the urine over 48 hours. … It slows the breakdown of fibrin clots to reduce bleeding by inhibiting the proteins plasminogen and kallikrein.

    Drugs: Calcium · Aprotinin
    Enzymes: Coagulation factor IX, Coagulation factor VIII
  6. Pathway

    Alteplase Action Pathway

    smpdb.ca/view/SMP0126634
    Drug action

    Alteplase is a recombinant plasminogen activator present in human tissue, also known as Activase, Cathflo and Cathflo Activase used to treat emergencies such as myocardial infarction, ischemic stroke and … Alteplase binds to fibrin and cleaves an arginine-valine bond of plasminogen converting it into its active form and acting on the fibrin matrix.

    Drugs: Alteplase · Calcium
    Enzymes: Coagulation factor IX, Coagulation factor VIII
  7. Pathway

    Apixaban Action Pathway (new)

    smpdb.ca/view/SMP0126437
    Drug action

    Apixaban is an oral anticoagulant drug that competitively inhibits free and bound coagulation factor X in the clotting cascade. … Used in the treatment and prevention of recurrent thromboembolic diseases, such as deep vein thrombosis and pulmonary embolisms.

    Drugs: Calcium · Apixaban
    Enzymes: Coagulation factor IX, Coagulation factor VIII
  8. Pathway

    Desirudin Action Pathway

    smpdb.ca/view/SMP0126434
    Drug action

    Due to the anticoagulant properties herbs and supplements with anticoagulant and antiplatelet activity should be avoided, this includes ginger, garlic, bilberry, danshen, piracetam and ginkgo biloba. … This drug is administered to prevent deep vein thrombosis, some possible side effects include bleeding gums, blood collecting under the skin, coughing up blood, bruising and difficulty breathing and or

    Drugs: Calcium · Desirudin
    Enzymes: Coagulation factor IX, Coagulation factor VIII
  9. Pathway

    Argatroban Action Pathway

    smpdb.ca/view/SMP0126440
    Drug action

    It can interact with food products so it is best to avoid herbs and supplements with anticoagulant and antiplatelet activity such as garlic, ginger, bilberry, danshen, piracetam and ginkgo biloba. … Commonly administered through intravenous injection with a half-life of 30 - 60 minutes and is primarily excreted through the feces, bile and urine.

    Drugs: Argatroban · Calcium
    Enzymes: Coagulation factor IX, Coagulation factor VIII
  10. Pathway

    Anistreplase Action Pathway (new)

    smpdb.ca/view/SMP0126638
    Drug action

    Anistreplase is a plasminogen activator created from recombinant human tissue, used in emergencies such as myocardial infarction and pulmonary emboli. … Due to its anticoagulant and antiplatelet activity, avoid herbs and supplements with similar activity such as garlic, ginger, bilberry, danshen, piracetam and ginkgo biloba.

    Drugs: Anistreplase · Calcium
    Enzymes: Coagulation factor IX, Coagulation factor VIII