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Rofecoxib
go.drugbank.com/drugs/DB00533ApprovedWithdrawnRofecoxib has a half-life of 17 hours and its mean oral bioavailability at therapeutically recommended doses of 125, 25, and 50 mg is approximately 93%. … The proteins that rofecoxib target include elastin and prostaglandin G/H synthase 2.
Synonyms: 3-phenyl-4-[4-(methylsulfonyl)phenyl]-2(5H)-furanone, 4-[4-(methylsulfonyl)phenyl]-3-phenyl-2(5H)-furanoneCategories: COX-2 Inhibitors, Selective Cyclooxygenase 2 Inhibitors (NSAIDs)Risperidone
go.drugbank.com/drugs/DB00734ApprovedInvestigationalRisperidone is thought to reduce this overactivity through inhibition of dopaminergic D2 receptors and serotonergic 5-HT2A receptors in the brain. … [L12885] Schizophrenia and various mood disorders are thought to be caused by an excess of dopaminergic D2 and serotonergic 5-HT2A activity, resulting in overactivity of central mesolimbic pathways
International brands: Risperidal M-TabCategories: Serotonin 5-HT1 Receptor Antagonists, Serotonin 5-HT2 Receptor AntagonistsDabigatran etexilate
go.drugbank.com/drugs/DB06695ApprovedInvestigational[A177463, A6970, L34675, L34680] Dabigatran etexilate may be used to decrease the risk of venous thromboembolic events in patients in whom anticoagulation therapy is indicated. … [A177463] In contrast to warfarin, because its anticoagulant effects are predictable, lab monitoring is not necessary.[A177463] Dabigatran etexilate was approved by the FDA in 2010.[L6022]
Categories: Heterocyclic Compounds, 2-Ring, P-glycoprotein substratesProducts: PRADAXA® 150 MG, DABIFIB 75 (Dabigatran Etexilate Hard Capsules 75 mg)Leuprolide
go.drugbank.com/drugs/DB00007ApprovedInvestigational[A203126, A203132] Leuprolide was first approved in 1985 as a daily subcutaneous injection under the tradename Lupron™ by Abbvie Endocrine Inc. … Prolonged activation of GnRHR results in significant downregulation of sex steroid levels, which is primarily responsible for the clinical efficacy of leuprolide in diverse conditions, including advanced
International brands: Prostap 3Products: ELIGARD ® 45 MG, LUCRIN INJECTION 5 mg/mlOctinoxate
go.drugbank.com/drugs/DB09496ApprovedInvestigationalIt was originally developed in 1950's as an organic UV-B filter that absorbs UV-B rays from sun. … Octinoxate is a cinnamate ester and common ingredient in sunscreen and other skin care products to minimize DNA photodamage.
Synonyms: ethylhexyl p-methoxycinnamateMixtures: A M Stimulus Complex SPF 25, Me Day T9 SPF 25Menotropins
go.drugbank.com/drugs/DB00032ApprovedInvestigationalIt is composed of LH with 2 subunits, alpha = 92 residues, beta = 121 residues and FSH with 2 subunits, alpha = 92 residues, beta=111 residues. … It is used as a fertility medication that is injected either subcutaneously or intramuscularly.
Products: Meriofert 75 I.E. Pulver und Lösungsmittel zur Herstellung einer Injektionslösung, Meriofert PFS 75 I.E. Pulver und Lösungsmittel zur Herstellung einer InjektionslösungCetirizine
go.drugbank.com/drugs/DB00341ApprovedInvestigationalThe prevalence of allergic rhinitis in the United States is about 15% according to physician diagnoses, and up to 30%, according to self-reported nasal symptoms. … Allergic rhinitis is associated with multiple missed or unproductive days at work and school, problems with sleep, and other difficulties with day to day activities for many individuals [A175057].
Mixtures: ACERADOX® G, Up and Up all day allergy relief dCategories: P-glycoprotein inhibitors, P-glycoprotein substratesLevofloxacin
go.drugbank.com/drugs/DB01137ApprovedInvestigational[A31453,A190756] Levofloxacin was first approved by the FDA in 1996, and was approved in Canada and several South American countries soon after.[A190663] … Levofloxacin is a fluoroquinolone antibiotic and the optical S-(-) isomer of racemic [ofloxacin].
Mixtures: TRILEVO 500 MG+30 MG+ 1000 MG TEDAVİ PAKETİ, Ducressa (Dexamethasone 1mg/ml + Levofloxacin 5mg/ml) eye drops, solutionCategories: MATE 2 Inhibitors, Heterocyclic Compounds, 2-RingZinc oxide
go.drugbank.com/drugs/DB09321ApprovedInvestigationalZinc oxide is an inorganic compound used in a number of manufacturing processes. … It is also widely used to treat a variety of other skin conditions, in products such as baby powder and barrier creams to treat diaper rashes, calamine cream, anti-dandruff shampoos, and antiseptic ointments
Mixtures: Calcium Mg and Zn Capsules With Vitamin D, DERIVERIN MERHEM, 25 GCategories: Compounds used in a research, industrial, or household settingOxycodone
go.drugbank.com/drugs/DB00497ApprovedIllicitInvestigationalOxycodone is a semisynthetic opioid analgesic derived from thebaine in Germany in 1917. … for an extended period.
Synonyms: 4,5-Epoxy-14-hydroxy-3-methoxy-17-methylmorphinan-6-one, 4,5α-Epoxy-14-hydroxy-3-methoxy-17-methylmorphinan-6-oneMixtures: DEPALGOS® 5 MG /325 MG, Targin 15 mg/7,5 mg Retardtabletten