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Doxorubicin
go.drugbank.com/drugs/DB00997ApprovedInvestigationalDoxorubicin is a cytotoxic anthracycline antibiotic isolated from cultures of Streptomyces peucetius var. caesius along side with daunorubicin, another cytotoxic agent, in 1970. Although they both have aglyconic and sugar moieties, doxor...
Categories: P-glycoprotein inducers, P-glycoprotein inhibitorsGuanfacine
go.drugbank.com/drugs/DB01018ApprovedInvestigationalGuanfacine, or BS 100-141, is a selective alpha-A2 adrenergic receptor agonist initially indicated for the treatment of hypertension but is now indicated as an extended release tablet for the treatment of ADHD. Guanfacine was first descr...
Categories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP3A SubstratesSelegiline
go.drugbank.com/drugs/DB01037ApprovedInvestigationalVet approvedA selective, irreversible inhibitor of Type B monoamine oxidase. It is used in newly diagnosed patients with Parkinson's disease. It may slow progression of the clinical disease and delay the requirement for levodopa therapy. It also may...
Categories: P-glycoprotein inhibitors, Cytochrome P-450 SubstratesMemantine
go.drugbank.com/drugs/DB01043ApprovedInvestigationalInitially approved by the FDA in 2013, memantine is an N-methyl-D-aspartate (NMDA) receptor antagonist used in the management of Alzheimer's Disease (AD). It is different from many other Alzheimer's Disease medications, as it works by a ...
Categories: Cytochrome P-450 CYP2A6 Inhibitors, Cytochrome P-450 CYP2B6 InhibitorsProducts: NEMET, Generic DrugFluocinonide
go.drugbank.com/drugs/DB01047ApprovedInvestigationalA topical glucocorticoid used in the treatment of eczema.
Categories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP3A InducersOxybutynin
go.drugbank.com/drugs/DB01062ApprovedInvestigationalOveractive bladder (OAB) is a common condition negatively impacting the lives of millions of patients worldwide. Due to its urinary symptoms that include nocturia, urgency, and frequency, this condition causes social embarrassment and a ...
Categories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP2C8 InhibitorsProducts: OSSIBUTININA CLORIDRATO MYLAN GENERICSAtorvastatin
go.drugbank.com/drugs/DB01076ApprovedInvestigationalAtorvastatin (Lipitor®), is a lipid-lowering drug included in the statin class of medications. By inhibiting the endogenous production of cholesterol in the liver, statins lower abnormal cholesterol and lipid levels, and ultimately reduc...
Categories: P-glycoprotein inhibitors, P-glycoprotein substratesProducts: ATORVASTATINA P-CARE, ATORVASTATINA DOC GENERICIPilocarpine
go.drugbank.com/drugs/DB01085ApprovedInvestigationalA naturally occurring alkaloid derived from the Pilocarpus plants, pilocarpine is a muscarinic acetylcholine agonist. Pilocarpine is associated with parasympathomimetic effects by selectively working on muscarinic receptors. Pilocarpine ...
Categories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP2A6 InhibitorsProguanil
go.drugbank.com/drugs/DB01131ApprovedProguanil is a prophylactic antimalarial drug, which works by stopping the malaria parasite, Plasmodium falciparum and Plasmodium vivax, from reproducing once it is in the red blood cells. It does this by inhibiting the enzyme, dihydrofo...
Mixtures: ATOVAQUONE E PROGUANILE MYLAN GENERICS, ATOVAQUONE E PROGUANILE MYLAN GENERICSCategories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP2C9 SubstratesPioglitazone
go.drugbank.com/drugs/DB01132ApprovedInvestigational[A19759] Thiazolidinediones, including pioglitazone, have fallen out of favor in recent years due to the presence of multiple adverse effects and warnings regarding their use (e.g. congestive heart
Mixtures: INCRESINA PCategories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP1A1 Substrates