Guanfacine

DB01018ApprovedInvestigationalSmall moleculeAntihypertensive Agents Indicated for HypertensionCentral alpha-2 Adrenergic AgonistCentral Alpha-agonists

Guanfacine is an alpha-2A adrenergic receptor agonist used to treat ADHD. Guanfacine was first described in the literature in 1974.

Chemical structure of Guanfacine
Mechanism
Curator reviewed · 2 references
Primary indication
Guanfacine is indicated alone or as an adjunct with stimulants to treat ADHD.Curator reviewed · 5 structured indications
Formula / weight
C9H9Cl2N3O · 246.093 g/mol (avg)
First approval
Canada, 2020 · United States, 1986 · European Union, 2016
Code names
SPD 503
Brand names
  • Intuniv
  • Tenex

Resolves to

Compound
UNII30OMY4G3MKCAS29110-47-2ChEMBLCHEMBL862ChEBI5558PubChem3519KEGGD08031
Clinical / RWD
RxNorm40114ATCC02AC02PharmGKBPA449825
Structure
InChIKeyINJOMKTZOLKMBF-UHFFFAOYSA-NSMILESNC(=N)NC(=O)CC1=C(Cl)C=CC=C1Cl
Targets
P08913ADRA2AP18089ADRA2B
Transporters
Q96FL8SLC47A1O15245SLC22A1O15244SLC22A2

What you can answer from here — as of September 23, 2026

3Protein targetsEach mapped to UniProt, with action and pharmacological action
Listed above
3TransportersSubstrate / inhibitor direction, not just membership
Listed above
1,787Drug interactionsStructured to mechanism, not free text
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67Clinical trialsPhase, status and sponsor resolved per trial
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5Structured indicationsCondition, population, route and combination as fields, not prose
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1ContraindicationEach with its own population and attribute set
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254Marketed productsAcross 4 countries and 60 labellers
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1ATC codeIncluding every combination product, plus 30 drug categories
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35+ReferencesStructured and connected to the statements they support
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Which drugs share a target with Guanfacine, and which of those have an active Phase 3 trial?

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