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Arachidonic Acid
go.drugbank.com/drugs/DB04557ApprovedInvestigationalWithdrawnAn unsaturated, essential fatty acid. It is found in animal and human fat as well as in the liver, brain, and glandular organs, and is a constituent of animal phosphatides. … It is formed by the synthesis from dietary linoleic acid and is a precursor in the biosynthesis of prostaglandins, thromboxanes, and leukotrienes. [PubChem]
Mixtures: NEUROGAIN PB VEGICAP CAPSULE 500MGCategories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP2C9 SubstratesIpilimumab
go.drugbank.com/drugs/DB06186ApprovedInvestigationalIpilimumab is a fully humanized IgG1 monoclonal antibody that blocks cytotoxic T lymphocyte antigen-4 (CTLA-4). … [L12126] Blocking CTLA-4 removes an inhibitory signal from reducing the activity of T lymphocytes.[A35065,A35080,L12126] Ipilimumab was developed by Bristol-Myers Squibb and Medarex.
Products: YERVOY 200MG/40ML IV INFUZYONLUK ÇOZELTI KONSANTRESI ICEREN FLAKON, 1 ADET, YERVOY 50MG/10ML IV INFUZYONLUK ÇOZELTI KONSANTRESI ICEREN FLAKON, 1 ADETSafinamide
go.drugbank.com/drugs/DB06654ApprovedInvestigationalSafinamide is for the treatment of parkinson's disease. It was approved in Europe in February 2015, and in the United States on March 21, 2017.
Categories: Monoamine Oxidase A Inhibitors for interaction with Monoamine Oxidase A substrates, Cytochrome P-450 SubstratesCilazapril
go.drugbank.com/drugs/DB01340ApprovedInvestigationalIt is branded as Inhibace in Canada and other countries, Vascace and Dynorm in a number of European countries, among many other names. None of these varieties are available in the United States. … It is a prodrug that is hydrolyzed after absorption to its main metabolite cilazaprilat.
Categories: P-glycoprotein inhibitorsFlumazenil
go.drugbank.com/drugs/DB01205ApprovedInvestigationalFumazenil is an imidazobenzodiazepine derivative and a potent benzodiazepine receptor antagonist that competitively inhibits the activity at the benzodiazepine recognition site on the GABA/benzodiazepine
Categories: Compounds used in a research, industrial, or household settingProducts: LAUZENİL 1MG/10ML IV ENJEKSİYONLUK ÇÖZELTİ, 5 ADET, LAUZENİL 0,5 MG/5 ML IV ENJEKSİYONLUK ÇÖZELTİ, 5 ADETPF-03654764
go.drugbank.com/drugs/DB12360InvestigationalPF-03654764 has been used in trials studying the basic science and treatment of Allergic Rhinitis.
Succinylcholine
go.drugbank.com/drugs/DB00202ApprovedInvestigational[A19054] It has been widely used for over 50 years,[A299] most commonly in its chloride salt form, as a means of neuromuscular blockade during intubation and surgical procedures. … Succinylcholine is a depolarizing skeletal muscle relaxant consisting of two molecules of the endogenous neurotransmitter [acetylcholine] (ACh) linked by their acetyl groups.
Mafenide
go.drugbank.com/drugs/DB06795ApprovedVet approvedWithdrawnMafenide is a sulfonamide-type antimicrobial agent used to treat severe burns. It acts by reducing the bacterial population present in the burn tissue and promotes healing of deep burns. … In November 2022, the use of mafenide acetate (powder for 5% topical solution) was withdrawn by the FDA due to an unresolved confirmatory study required to fulfill the accelerated approval requirements
Sparsentan
go.drugbank.com/drugs/DB12548ApprovedInvestigational>A</sub>R and 0.8 nM for AT<sub>1</sub>R). … Sparsentan is a dual antagonist of the endothelin type A receptor (ET<sub>A</sub>R) and the angiotensin II (Ang II) type 1 receptor (AT<sub>1</sub>R) with a similar affinity for both (9.3 nM for ET<sub
Categories: Dual Endothelin Type A Receptor/Ang II Subtype 1 Receptor Antagonist (DEARA), P-glycoprotein inhibitorsPotassium gluconate
go.drugbank.com/drugs/DB13620ApprovedPotassium gluconate is a salt of [DB01345] and is classified as a food additive by the FDA [L2654]. It is also used as a potassium supplement [L2657]. Potassium is an essential nutrient. … It is the most abundant cation in the intracellular fluid, where it plays a key role in maintaining cell function [A32222].