Mafenide is an antimicrobial topical agent indicated for use as an adjunctive treatment to control bacterial infection when used under moist dressings over meshed autografts on excised burn wounds. It acts by reducing the bacterial population present in the burn tissue and promotes healing of deep burns.
- Mechanism
- Curator reviewed
The precise mechanism of mafenide is unknown. However, mafenide reduces the bacterial population in the avascular burn tissue and promotes spontaneous heeling of deep burns.
- Primary indication
- Indicated for use as an adjunctive topical antimicrobial agent to control bacterial infection when used under moist dressings over meshed autografts on excised burn wounds.Curator reviewed
- Formula / weight
- C7H10N2O2S · 186.232 g/mol (avg)
- First approval
- Canada, 1999 · United States, 1998
- Also known as
- 4-Homosufanilamide · Bensulfamide · Maphenidum
- Code names
- D06BA03 · NSC-34632
- Brand names
Resolves to
Clinical / RWD
Structure
InChIKey
TYMRLRRVMHJFTF-UHFFFAOYSA-NSMILESNCC1=CC=C(C=C1)S(N)(=O)=OWhat you can answer from here — as of September 13, 2026
6Protein targetsEach mapped to UniProt, with action and pharmacological actionListed above
Which drugs share a target with Mafenide, and which of those have an active Phase 3 trial?
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