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Displaying results 1181 - 1190 of 10000 in total
  1. Target

    Hyaluronan and proteoglycan link protein 1

    go.drugbank.com/bio_entities/BE0004933
    TargetHumans

    Stabilizes the aggregates of proteoglycan monomers with hyaluronic acid in the extracellular cartilage matrix

    Polypeptides: Hyaluronan and proteoglycan link protein 1
  2. Target

    Hyaluronan and proteoglycan link protein 3

    go.drugbank.com/bio_entities/BE0004935
    TargetHumans

    May function in hyaluronic acid binding

    Polypeptides: Hyaluronan and proteoglycan link protein 3
  3. Target

    Calcium and integrin-binding protein 1

    go.drugbank.com/bio_entities/BE0008691
    TargetHumans

    Forms a complex with TMC6/EVER1 and TMC8/EVER2 in lymphocytes and keratynocytes where CIB1 stabilizes TMC6 and TMC8 levels and reciprocally (PubMed:30068544, PubMed:32917726) … Also promotes cancer cell survival and proliferation. May regulate cell cycle and differentiation of spermatogenic germ cells, and/or differentiation of supporting Sertoli cells.

    Polypeptides: Calcium and integrin-binding protein 1Synonyms: Calcium- and integrin-binding protein
  4. Drug

    Palbociclib

    go.drugbank.com/drugs/DB09073
    ApprovedInvestigational

    patients based on findings from postmarketing reports and electronic health records demonstrating safety and clinical efficacy. … [A176810] Palbociclib was developed by Pfizer Inc after the discovery that identified the cyclin-dependent kinases as key regulators of cell growth.

    Categories: Antineoplastic and Immunomodulating AgentsProducts: Ibrance Capsules 100mg, IBRANCE CAPSULE 100mg
  5. Drug

    Tenoxicam

    go.drugbank.com/drugs/DB00469
    ApprovedInvestigational

    Tenoxicam, an antiinflammatory agent with analgesic and antipyretic properties, is used to treat osteoarthritis and control acute pain.

    Categories: Antiinflammatory and Antirheumatic Products, Non-Steroids, Antiinflammatory and Antirheumatic ProductsProducts: Mobiflex Tab 20mg, ANALCAM TABLET 20MG
  6. Drug

    Talazoparib

    go.drugbank.com/drugs/DB11760
    ApprovedInvestigational

    [L47236] Developed by Pfizer, talazoparib was first approved by the FDA in October 2018 [A260346] and by the EMA in June 2019.[L47296] It was approved by Health Canada in September 2020. … Talazoparib is an inhibitor of mammalian polyadenosine 5’-diphosphoribose polymerases (PARPs), enzymes responsible for regulating essential cellular functions, such as DNA transcription and DNA repair.

    Categories: Antineoplastic and Immunomodulating AgentsProducts: TALZENNA CAPSULE 1MG, Talzenna 1mg Hard Capsules
  7. Drug

    Brigatinib

    go.drugbank.com/drugs/DB12267
    ApprovedInvestigational

    [A31313] Brigatinib was developed by Ariad Pharmaceuticals, a subsidiary of Takeda Pharmaceutical Company Limited, and FDA-approved on April 28, 2017.[L1026] … Brigatinib, originally named AP26113, is a reversible dual inhibitor of anaplastic lymphoma kinase (ALK) and epidermal growth factor receptor (EGFR).

    Categories: Antineoplastic and Immunomodulating AgentsProducts: ALUNBRIG FILM-COATED TABLET 180mg, Alunbrig (Brigatinib) 180mg Film-Coated Tablet
  8. Drug

    Disulfiram

    go.drugbank.com/drugs/DB00822
    ApprovedInvestigational

    A carbamate derivative used as an alcohol deterrent. It is a relatively nontoxic substance when administered alone, but markedly alters the intermediary metabolism of alcohol. … and other symptoms (acetaldehyde syndrome).

    Categories: Scabicides, Insecticides and Repellents, Antiparasitic Products, Insecticides and RepellentsSynonyms: N,N,N',N'-tetraethylthiuram disulfide, 1,1'-dithiobis(N,N-diethylthioformamide)
  9. Drug

    Tafamidis

    go.drugbank.com/drugs/DB11644
    ApprovedInvestigational

    Tafamidis and tafamidis meglumine (FX-1006A) are benzoxazole derivatives[A27206] developed by FoldRX.[A189717] Tafamidis is structurally similar to diflusinal. … [A189717] Tafamidis was granted an EMA market authorisation on 16 November 2011[L6247] and FDA approval on 3 May 2019.[L11280]

    Categories: Hormones, Hormone Substitutes, and Hormone AntagonistsProducts: VYNDAQEL SOFT GELATIN CAPSULE 20MG
  10. Drug

    Triptorelin

    go.drugbank.com/drugs/DB06825
    ApprovedInvestigationalVet approved

    After chronic, continuous administration, this agent effects sustained decreases in LH and FSH production and testicular and ovarian steroidogenesis. … Serum testosterone concentrations may fall to levels typically observed in surgically castrated men.

    Categories: Hormones and Related Agents, Amino Acids, Peptides, and ProteinsProducts: POWDER AND SOLVENT FOR SUSPENSION FOR INJECTION 3.75 mg/vial, POWDER AND SOLVENT FOR SUSPENSION FOR INJECTION 11.25 mg/vial