Triptorelin

DB06825ApprovedInvestigationalVet approvedSmall moleculeGonadotropin Releasing Hormone Receptor Agonist

Triptorelin is a GnRH agonist indicated for the palliative treatment of advanced prostate cancer. Triptorelin is a synthetic decapeptide agonist analog of luteinizing hormone releasing hormone (LHRH).

Mechanism: Triptorelin is a synthetic agonist analog of gonadotropin releasing hormone (GnRH). Animal studies comparing triptorelin to native GnRH found that triptorelin had 13 fold higher releasing activity for luteinizing hormone, and 21-fold higher releasing activity for follicle-stimulating hormone.
Curator reviewed
Primary indication: Triptorelin is indicated for the palliative treatment of advanced prostate cancer.Curator reviewed · 2 structured indications
Formula / weight: C₆₄H₈₂N₁₈O₁₃ · 1311.473 g/mol (avg)
First approval: Canada, 2012 · United States, 2000
Code names: AY-25650 · CL-118,532 · WY-42462
Brand names: Decapeptyl
Trelstar
Triptodur

Resolves to

Compound

UNII9081Y98W2VCAS57773-63-4ChEMBLCHEMBL1201334ChEBI63633PubChem25074470KEGGD06247

Clinical / RWD

RxNorm38782ATCL02AE04

Structure

InChIKeyVXKHXGOKWPXYNA-PGBVPBMZSA-NSMILES

CC(C)C[C@H](NC(=O)[C@@H](CC1=CNC2=CC=CC=C12)NC(=O)[C@H](CC1=CC=C(O)C=C1)NC(=O)[C@H](CO)NC(=O)[C@H](CC1=CNC2=C1C=CC=C2)NC(=O)[C@H](CC1=CNC=N1)NC(=O)[C@@H]1CCC(=O)N1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N1CCC[C@H]1C(=O)NCC(N)=O

Targets

P30968GNRHR

What you can answer from here — as of September 23, 2026

1Protein targetEach mapped to UniProt, with action and pharmacological action

Listed above

941Drug interactionsStructured to mechanism, not free text

209Clinical trialsPhase, status and sponsor resolved per trial

2Structured indicationsCondition, population, route and combination as fields, not prose

1ContraindicationEach with its own population and attribute set

67Marketed productsAcross 10 countries and 22 labellers

1ATC codeIncluding every combination product, plus 28 drug categories

4+ReferencesStructured and connected to the statements they support

Which drugs share a target with Triptorelin, and which of those have an active Phase 3 trial?

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