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Ephedra sinica root
go.drugbank.com/drugs/DB01363ApprovedNutraceuticalThe sale of ephedra-containing supplements intended to increase muscle weight or promote weight loss was banned in the United States in 2004 due to the risk for adverse effects and a lack of evidence for … Ephedra is an alkaloid chemical compound traditionally obtained from the plant _Ephedra sinica_.
Telmisartan
go.drugbank.com/drugs/DB00966ApprovedInvestigationalGenerally, angiotensin II receptor blockers (ARBs) such as telmisartan bind to the angiotensin II type 1 (AT1) receptors with high affinity, causing inhibition of the action of angiotensin II on vascular … smooth muscle, ultimately leading to a reduction in arterial blood pressure.
Mixtures: TELMISARTAN E IDROCLOROTIAZIDE EG, TELMISARTAN E IDROCLOROTIAZIDE EGCategories: Agents Acting on the Renin-Angiotensin SystemThonzylamine
go.drugbank.com/drugs/DB11235ApprovedThonzylamine is an antihistamine and anticholinergic drug. It is available as combination products with DB04837 or DB00388 for temporary relief of symptoms of common cold, hay fever (allergic rhinitis) or other upper respiratory allergies.
Mixtures: Nasopen PEAminohippuric acid
go.drugbank.com/drugs/DB00345ApprovedInvestigationalWithdrawnThe glycine amide of 4-aminobenzoic acid. Its sodium salt is used as a diagnostic aid to measure effective renal plasma flow (ERPF) and excretory capacity. [PubChem]
Famtozinameran
go.drugbank.com/drugs/DB17088ApprovedInvestigational[L43917] As of November 2022, it is the primary circulating variant of concern according to the World Health Organization. … [L43922] It tends to cause less severe disease but is significantly more virulent than both the original virus and earlier variants (e.g. Delta).
Aducanumab
go.drugbank.com/drugs/DB12274ApprovedInvestigational[L34420] Biogen enrolled patients in phase 3 clinical trials in 2015 but increased the size of the trials from 1350 patients to 1650 patients to maintain statistical power in the face of a high standard … [L34393] In January 2024, Biogen announced that the development and commercialization of aducanumab will be discontinued to prioritize the marketing of [lecanemab], another drug approved for the treatment
Samidorphan
go.drugbank.com/drugs/DB12543ApprovedInvestigationalmay be expected to ameliorate these negative effects. … [A235638, A235643] Samidorphan was first approved as a variety of fixed-dose combination tablets with [olanzapine] by the FDA on May 28, 2021, and is currently marketed under the trademark LYBALVI™
Gelatin
go.drugbank.com/drugs/DB11242ApprovedInvestigationalVet approvedWithdrawn[A32426] Gelatin is generally recognized as safe (GRAS) by the FDA to be a non-hazardous food or food ingredient. … [L2110] The FDA withdrew its approval for the use of all intravenous drug products containing gelatin. Gelatin continues to be approved for other routes of administration.[L43942]
Vericiguat
go.drugbank.com/drugs/DB15456ApprovedInvestigational[L31153] A key component of the NO-sGC-cGMP signaling pathway that helps to regulate the cardiovascular system, sGC enzymes are intracellular enzymes found in vascular smooth muscle cells (amongst other … cell types) that catalyze the synthesis of cyclic guanosine monophosphate (cGMP) in response to activation by nitric oxide (NO).
Ziconotide
go.drugbank.com/drugs/DB06283ApprovedInvestigational[L13389] To date, ziconotide is the only calcium channel blocking peptide approved for use by the FDA.[A202835] … [A202829, A202832] Ziconotide is used to manage severe chronic pain refractory to other methods, through its ability to inhibit N-type calcium channels involved in nociceptive signalling.