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Displaying results 111 - 120 of 134474 in total
  1. Pathway

    Tenecteplase Action Pathway (new)

    smpdb.ca/view/SMP0126640
    Drug action

    Tenecteplase is a plasminogen activator, a modified form of recombinant human tissue, also known as Metalyse and Tnkase, used in emergencies such as myocardial infarction and pulmonary emboli. … Due to its anticoagulant and antiplatelet activity herbs and supplements with similar activity should be avoided such as garlic, ginger, bilberry, danshen, piracetam and ginkgo biloba.

    Drugs: Tenecteplase · Calcium
    Enzymes: Coagulation factor IX, Coagulation factor VIII
  2. Pathway

    Turoctocog Alfa Action Pathway

    smpdb.ca/view/SMP0126775
    Drug action

    It is administered intravenously and acts similarly to coagulation factor VIII, forming a complex with IX in order to activate factor X leading to a blood clot forming. … Turoctocog alfa allows the missing factor coagulation VIII to be replaced and restore blood clotting.

    Drugs: Calcium · Turoctocog alfa
    Enzymes: Coagulation factor IX, Coagulation factor VIII
  3. Pathway

    Emicizumab Action Pathway

    smpdb.ca/view/SMP0126843
    Drug action

    Emicizumab also known as Hemlibra, is a humanized recombinant monoclonal antibody that mimics coagulation factor VIII and can bind to activated coagulation factor IX and X. … Emicizumab performs the function of coagulation factor VIII, with the ability to also bind to both coagulation factor IX and X.

    Drugs: Calcium · Emicizumab
    Enzymes: Coagulation factor IX, Coagulation factor VIII
  4. Pathway

    Turoctocog Alfa Pegol Action Pathway

    smpdb.ca/view/SMP0126856
    Drug action

    It acts by replacing coagulation factor VIII which is deficient in patients with hemophilia. … The difference between turoctocog alfa pegol and turoctocog alfa is the modification to the structure of turoctocog alfa pegol extends its half-life.

    Drugs: Calcium · Turoctocog alfa pegol
    Enzymes: Coagulation factor IX, Coagulation factor VIII
  5. Pathway

    Dabigatran Etexilate Action Pathway

    smpdb.ca/view/SMP0126433
    Drug action

    This drug does interact with food, herbs and supplements with anticoagulant and antiplatelet activity should be avoided such as garlic, ginger, bilberry, danshen, piracetam and ginkgo biloba. St. … Dabigatran competitively binds and inhibits thrombin by doing so stops the formation of fibrin and therefore the meshwork for a thrombus.

    Drugs: Calcium · Dabigatran etexilate
    Enzymes: Coagulation factor IX, Coagulation factor VIII
  6. Pathway

    Betrixaban Action Pathway

    smpdb.ca/view/SMP0126432
    Drug action

    Due to its interaction with factor Xa, the coagulant factor is no longer free and unable to form the prothrombinase complex. … Betrixaban is an anticoagulant that targets and inhibits factor Xa in order to prevent venous thromboembolism.

    Drugs: Calcium
    Enzymes: Coagulation factor IX, Coagulation factor VIII
  7. Pathway

    Rivaroxaban Action Pathway

    smpdb.ca/view/SMP0126439
    Drug action

    Rivaroxaban is an anticoagulant that inhibits coagulation factor X, typically used to treat deep vein thrombosis (DVT) and pulmonary embolism (PE). … Rivaroxaban competitively inhibits free and clot-bound factor X. Coagulation factor X makes up a part of the prothrombinase complex that is responsible for the conversion of prothrombin to thrombin.

    Drugs: Calcium
    Enzymes: Coagulation factor IX, Coagulation factor VIII
  8. Pathway

    Reteplase Action Pathway (new)

    smpdb.ca/view/SMP0126637
    Drug action

    Reteplase is a plasminogen activator that is created as a purified form of human tissue, also known as Retavase that is used in emergencies such as myocardial infarction, ischemic stroke and pulmonary … Reteplase is administered intravenously and travels through the bloodstream and acts on plasminogen cleaving an arginine-valine bond converting it to its active form plasmin.

    Drugs: Reteplase · Calcium
    Enzymes: Coagulation factor IX, Coagulation factor VIII
  9. Pathway

    Streptokinase Action Pathway (new)

    smpdb.ca/view/SMP0126642
    Drug action

    Due to the anticoagulant and antiplatelet activity, herbs and supplements with a similar activity should be avoided such as garlic, ginger, bilberry, danshen, piracetam and ginkgo biloba. … Streptokinase is a bacterial protein that is fibrinolytic and used to break down blood clots in myocardial infarction, pulmonary embolism and venous thromboembolism.

    Drugs: Streptokinase · Calcium
    Enzymes: Coagulation factor IX, Coagulation factor VIII
  10. Pathway

    Lonoctocog Alfa Action Pathway

    smpdb.ca/view/SMP0126848
    Drug action

    Lonoctocog alfa also known as Afstyla is a recombinant coagulation factor VIII that is used in the treatment of hemophilia A. … Once administered intravenously it binds to the coagulation factor IXa to convert coagulation factor X to its active form Xa to carry on the reactions of the clotting cascade.

    Drugs: Calcium · Lonoctocog alfa
    Enzymes: Coagulation factor IX, Coagulation factor VIII