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Displaying results 111 - 120 of 1841 in total
  1. Pathway

    Methyclothiazide Action Pathway

    smpdb.ca/view/SMP0000081
    Drug action

    Solute carrier family 12 member 3 transports chloride and sodium from lumen to epithelial cell, and sodium/potassium ATPases facilitate the export of sodium to basolateral interstitium to provide sodium … It can inhibit the solute carrier family 12 member 3 (also known as sodium-chloride symporter) in the nephron to prevent water reabsorption.

    Drugs: Cysteine · Methyclothiazide · Potassium cation · Urea
    Enzymes: Chloride channel protein ClC-Ka, Sodium- and chloride-dependent transporter XTRP3
  2. Pathway

    Hydroflumethiazide Action Pathway

    smpdb.ca/view/SMP0000108
    Drug action

    Solute carrier family 12 member 3 transports chloride and sodium from lumen to epithelial cell, and sodium/potassium ATPases facilitate the export of sodium to basolateral interstitium to provide sodium … It can inhibit the solute carrier family 12 member 3 (also known as sodium-chloride symporter) in the nephron to prevent water reabsorption.

    Drugs: Cysteine · Hydroflumethiazide · Potassium cation · Urea
    Enzymes: Chloride channel protein ClC-Ka, Sodium- and chloride-dependent transporter XTRP3
  3. Pathway

    Furosemide Action Pathway

    smpdb.ca/view/SMP0000115
    Drug action

    Furosemide can bind and inhibit sodium-potassium-chloride cotransporter (NKCC2/SLC22A1) to prevent the water reabsorption in nephron. … Inhibition of sodium-potassium-chloride cotransporter can prevent transportation of sodium from lumen to basolateral interstitium, which lead to more hypertonic in lumen and less hypertonic in basolateral

    Drugs: Cysteine · Furosemide · Potassium cation · Urea
    Enzymes: Chloride channel protein ClC-Ka, Sodium- and chloride-dependent transporter XTRP3
  4. Pathway

    Trichlormethiazide Action Pathway

    smpdb.ca/view/SMP0000121
    Drug action

    Trichlormethiazide also acts to inhibit sodium uptake and increase potassium excretion which also serves to increase fluid loss. … Trichloromethiazide acts by inhibiting chloride and potentially sodium reabsorption in the ascending loop of Henle, specifically at solute carrier family 12 member 3.

    Drugs: Cysteine · Trichlormethiazide · Potassium cation · Urea
    Enzymes: Chloride channel protein ClC-Ka, Sodium- and chloride-dependent transporter XTRP3
  5. Pathway

    Chlorothiazide Action Pathway

    smpdb.ca/view/SMP0000078
    Drug action

    Solute carrier family 12 member 3 transports chloride and sodium from lumen to epithelial cell, and sodium/potassium ATPases facilitate the export of sodium to basolateral interstitium to provide sodium … It can inhibit the solute carrier family 12 member 3 (also known as sodium-chloride symporter) in the nephron to prevent water reabsorption.

    Drugs: Cysteine · Chlorothiazide · Potassium cation · Urea
    Enzymes: Chloride channel protein ClC-Ka, Sodium- and chloride-dependent transporter XTRP3
  6. Pathway

    Bumetanide Action Pathway

    smpdb.ca/view/SMP0000088
    Drug action

    In the thick ascending limb of the loop of Henle, the sodium-potassium-chloride cotransporter (NKCC2) is competitively inhibited at the chloride binding site blocking sodium transport from the lumen to

    Drugs: Cysteine · Bumetanide · Potassium cation · Urea
    Enzymes: Chloride channel protein ClC-Ka, Sodium- and chloride-dependent transporter XTRP3
  7. Pathway

    Cyclothiazide Action Pathway

    smpdb.ca/view/SMP0000103
    Drug action

    Solute carrier family 12 member 3 transports chloride and sodium from lumen to epithelial cell, and sodium/potassium ATPases facilitate the export of sodium to basolateral interstitium to provide sodium … It can inhibit the solute carrier family 12 member 3 (also known as sodium-chloride symporter) in the nephron to prevent water reabsorption.

    Drugs: Cysteine · Cyclothiazide · Potassium cation · Urea
    Enzymes: Chloride channel protein ClC-Ka, Sodium- and chloride-dependent transporter XTRP3
  8. Pathway

    Metolazone Action Pathway (old)

    smpdb.ca/view/SMP0000105
    Drug action

    Solute carrier family 12 member 3 transports chloride and sodium from lumen to epithelial cell, and sodium/potassium ATPases facilitate the export of sodium to basolateral interstitium to provide sodium … It can inhibit the solute carrier family 12 member 3 (also known as sodium-chloride symporter) in the nephron to prevent water reabsorption.

    Drugs: Cysteine · Metolazone · Potassium cation · Urea
    Enzymes: Chloride channel protein ClC-Ka, Sodium- and chloride-dependent transporter XTRP3
  9. Pathway

    Chlorthalidone Action Pathway

    smpdb.ca/view/SMP0000122
    Drug action

    Solute carrier family 12 member 3 transports chloride and sodium from lumen to epithelial cell, and sodium/potassium ATPases facilitate the export of sodium to basolateral interstitium to provide sodium … It can inhibit the solute carrier family 12 member 3 (also known as sodium-chloride symporter) in the nephron to prevent water reabsorption.

    Drugs: Cysteine · Chlorthalidone · Potassium cation · Urea
    Enzymes: Chloride channel protein ClC-Ka, Sodium- and chloride-dependent transporter XTRP3
  10. Drug

    Torasemide

    go.drugbank.com/drugs/DB00214
    ApprovedInvestigational

    Torasemide is a high-ceiling loop diuretic. Structurally, it is a pyridine-sulfonylurea used as an antihypertensive agent. Torasemide was first approved for clinical use by the FDA in 1993.

    Categories: Sodium Potassium Chloride Symporter Inhibitors, Non Potassium Sparing Diuretics