Metolazone is a thiazide-like diuretic used to treat hypertension. A quinazoline-sulfonamide that is considered a thiazide-like diuretic which is long-acting so useful in chronic renal failure.
- Mechanism
- Curator reviewed
The actions of metolazone result from interference with the renal tubular mechanism of electrolyte reabsorption. Metolazone acts primarily to inhibit sodium reabsorption at the cortical diluting site and to a lesser extent in the proximal convoluted tubule. Sodium and chloride ions are excreted in approximately equivalent amounts. The increased delivery of sodium to the distal tubular exchange site results in increased potassium excretion. Metolazone does not inhibit carbonic anhydrase. The antihypertensive mechanism of action of metolazone is not fully understood but is presumed to be related to its saluretic and diuretic properties.
- Primary indication
- For the treatment of hypertension, alone or in combination with other antihypertensive drugs of a different class.Curator reviewed · 6 structured indications
- Formula / weight
- C16H16ClN3O3S · 365.835 g/mol (avg)
- First approval
- Canada, 2000 · United States, 1973
- Code names
- SR 720-22
- Brand names
Resolves to
AQCHWTWZEMGIFD-UHFFFAOYSA-NSMILESCC1NC2=CC(Cl)=C(C=C2C(=O)N1C1=CC=CC=C1C)S(N)(=O)=OWhat you can answer from here — as of September 23, 2026
Which drugs share a target with Metolazone, and which of those have an active Phase 3 trial?
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