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Fulvestrant
go.drugbank.com/drugs/DB00947ApprovedInvestigationalIt is an estrogen receptor antagonist with no agonist effects, which works both by down-regulating and by degrading the estrogen receptor. … Fulvestrant is a drug treatment of hormone receptor (HR)-positive metastatic breast cancer in post-menopausal women with disease progression following anti-estrogen therapy.
Categories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP3A SubstratesSynonyms: (7α,17β)-7-{9-[(4,4,5,5,5-pentafluoropentyl)sulfinyl]nonyl}estra-1(10),2,4-triene-3,17-diolMetoprolol
go.drugbank.com/drugs/DB00264ApprovedInvestigational[A175162] Metoprolol was developed since 1969 by US Pharmaceutical Holdings I and FDA approved in 1978.[L5527] … Metoprolol is a selective beta-1 blocker commonly employed as the succinate and tartrate derivatives depending if the formulation is designed to be of immediate release or extended release.
Mixtures: Implicor 50 mg/5 mg Filmtabletten, IMPLICOR FILM-COATED TABLET 50 mg/5 mgCategories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP3A SubstratesCefadroxil
go.drugbank.com/drugs/DB01140ApprovedInvestigationalVet approvedWithdrawnLong-acting, broad-spectrum, water-soluble, cephalexin derivative.
Categories: Heterocyclic Compounds, 2-RingSynonyms: D-CefadroxilAmikacin
go.drugbank.com/drugs/DB00479ApprovedInvestigationalVet approvedM. fortuitum)[L4680]. … M. avium-intracellulare (MAC) is a type of nontuberculous mycobacteria (NTM) found in water and soil.
Synonyms: 1-N-(L(−)-γ-amino-α-hydroxybutyryl)kanamycin A, D-STREPTAMINE, O-3-AMINO-3-DEOXY-.ALPHA.-D-GLUCOPYRANOSYL-(1->6)-O-(6-AMINO-6-DEOXY-.ALPHA.-D-GLUCOPYRANOSYL-(1->4))-N(SUP 1)-(4-AMINO-2-HYDROXY-1-OXOBUTYL)-2-DEOXY-, (S)-Categories: Drugs that are Mainly Renally Excreted with a Narrow Therapeutic IndexZuclopenthixol
go.drugbank.com/drugs/DB01624ApprovedInvestigationalKnown drug targets of zuclopenthixol include 5-hydroxytryptamine receptor 2A, D(1B) dopamine receptor, D(2) dopamine receptor, D(1A) dopamine receptor, and alpha-1A adrenergic receptor. … These are organic polycyclic compounds containing a thioxanthene moiety, which is an aromatic tricycle derived from xanthene by replacing the oxygen atom with a sulfur atom.
Categories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP3A SubstratesSynonyms: (Z)-4-(3-(2-Chlorothioxanthen-9-ylidene)propyl)-1-piperazineethanolZidovudine
go.drugbank.com/drugs/DB00495ApprovedInvestigationalA dideoxynucleoside compound in which the 3'-hydroxy group on the sugar moiety has been replaced by an azido group. … The compound is a potent inhibitor of HIV replication, acting as a chain-terminator of viral DNA during reverse transcription.
Mixtures: LAMIVUDINA 150 MG + ZIDOVUDINA 300 MG + NEVIRAPINA 200 MG TABLETAS CUBIERTAS, LAMIVUDINA 150 MG + ZIDOVUDINA 300 MG + NEVIRAPINA 200 MG TABLETAS CUBIERTASCategories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP3A SubstratesLevofloxacin
go.drugbank.com/drugs/DB01137ApprovedInvestigationalLevofloxacin is a fluoroquinolone antibiotic and the optical S-(-) isomer of racemic [ofloxacin]. … [A190663] It reportedly carries 8 to 128-fold more activity against both gram-negative and gram-positive bacteria compared to R-(+)-ofloxacin[A190663] and remains stereochemically stable following administration
Synonyms: (S)-(-)-9-fluoro-3-methyl-10-(4-methyl-1-piperazinyl)-7-oxo-2,3-dihydro-7H-pyrido[1,2,3-de][1,4]benzooxazine-6-carboxylic acid, (3S)-(-)-9-fluoro-3-methyl-10-(4-methyl-1-piperazinyl)-7-oxo-2,3-dihydro-7H-pyrido[1,2,3-de][1,4]benzoxazine-6-carboxylic acidMixtures: TRILEVO 500 MG+30 MG+ 1000 MG TEDAVİ PAKETİ, Ducressa (Dexamethasone 1mg/ml + Levofloxacin 5mg/ml) eye drops, solutionKetoprofen
go.drugbank.com/drugs/DB01009ApprovedInvestigationalVet approvedKetoprofen, a propionic acid derivative, is a nonsteroidal anti-inflammatory agent (NSAIA) with analgesic and antipyretic properties.
Synonyms: m-Benzoylhydratropic acid, 2-(3-Benzoylphenyl)propionic acidCategories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP2C8 InhibitorsHepatitis B immune globulin
go.drugbank.com/drugs/DB05276ApprovedInvestigationalLong-term hepatitis B immune globulin (HBIG) has been shown to reduce hepatitis B virus (HBV) reinfection in patients transplanted for hepatitis B. … Infection with hepatitis B may lead to hepatocellular carcinoma, a type of liver cancer. Therefore, the hepatitis-B vaccines are cancer-preventing vaccines.
Categories: hepatitis B immunoglobulinSynonyms: Hepatitis B immune globulin, Hepatitis B immune globulin humanAlbuterol
go.drugbank.com/drugs/DB01001ApprovedInvestigationalVet approvedThe R-isomer has 150 times greater affinity for the beta2-receptor than the S-isomer and the S-isomer has been associated with toxicity. … Salbutamol is formulated as a racemic mixture of the R- and S-isomers.
Mixtures: Ibicar S (Salbutamol 100 mcg/actuation and Beclometasone 50 mcg/actuation) Pressurised Inhalation, SALBUTAMOLO E IPRATROPIO BROMURO EGCategories: Cytochrome P-450 CYP3A Inhibitors, Cytochrome P-450 CYP3A4 Inhibitors