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Clonidine
go.drugbank.com/drugs/DB00575ApprovedInvestigationalClonidine is an imidazole derivate that acts as an agonist of alpha-2 adrenoceptors. This activity is useful for the treatment of hypertension, severe pain, and ADHD. Clonidine was granted FDA approval on 3 September 1974.
Categories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP3A SubstratesSynonyms: 2,6-Dichloro-N-2-imidazolidinylidenebenzenamineAllantoin
go.drugbank.com/drugs/DB11100ApprovedInvestigationalAllantoin is a substance that is endogenous to the human body and also found as a normal component of human diets [FDA Label]. In healthy human volunteers, the mean plasma concentration of allantoin is about 2-3 mg/l. During exercise, th...
Mixtures: Renuu NLSynonyms: N-(2,5-Dioxo-4-imidazolidinyl)ureaPropylene glycol
go.drugbank.com/drugs/DB01839ApprovedInvestigationalA clear, colorless, viscous organic solvent and diluent used in pharmaceutical preparations.
Mixtures: Hydration PF, Systane Hydration PF Preservative FreeProducts: Systane COMPLETE PFPaclitaxel
go.drugbank.com/drugs/DB01229ApprovedInvestigationalVet approvedPaclitaxel is a chemotherapeutic agent marketed under the brand name Taxol among others. Used as a treatment for various cancers, paclitaxel is a mitotic inhibitor that was first isolated in 1971 from the bark of the Pacific yew tree whi...
Categories: P-glycoprotein inhibitors, P-glycoprotein substratesSynonyms: 5beta,20-Epoxy-1,2-alpha,4,7beta,10beta,13alpha-hexahydroxytax-11-en-9-one 4,10-diacetate 2-benzoate 13-ester with (2R,3S)-N-benzoyl-3-phenylisoserineNimesulide
go.drugbank.com/drugs/DB04743ApprovedInvestigationalWithdrawnNimesulide is a relatively COX-2 selective, non-steroidal anti-inflammatory drug (NSAID) with analgesic and antipyretic properties. Its approved indications are the treatment of acute pain, the symptomatic treatment of osteoarthritis and...
Categories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP3A SubstratesProducts: SEVERIN NF, NI-M-DOL® (NIMESULIDA SUSPENSION)Salicylic acid
go.drugbank.com/drugs/DB00936ApprovedInvestigationalVet approvedA compound obtained from the bark of the white willow and wintergreen leaves, and also prepared synthetically. It has bacteriostatic, fungicidal, and keratolytic actions. Its salts, the salicylates, are used as analgesics.
Mixtures: P&s Plus, PM ExternalCategories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP2C9 SubstratesButylene glycol
go.drugbank.com/drugs/DB14110ApprovedProducts: PLAY and JOY Cologne Maca Extra Hot Lubricant PJ-LBS201-35EUAtenolol
go.drugbank.com/drugs/DB00335ApprovedInvestigationalAtenolol is a cardioselective beta-blocker used in a variety of cardiovascular conditions. Sir James Black, a Scottish pharmacologist, pioneered the use of beta-blockers for the management of angina pectoris in 1958 for which he received...
Categories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP2D6 SubstratesSynonyms: 1-p-Carbamoylmethylphenoxy-3-isopropylamino-2-propanol, 2-(p-(2-Hydroxy-3-(isopropylamino)propoxy)phenyl)acetamideSelegiline
go.drugbank.com/drugs/DB01037ApprovedVet approvedA selective, irreversible inhibitor of Type B monoamine oxidase. It is used in newly diagnosed patients with Parkinson's disease. It may slow progression of the clinical disease and delay the requirement for levodopa therapy. It also may...
Categories: P-glycoprotein inhibitors, Cytochrome P-450 SubstratesProducts: Nu-selegilineNizatidine
go.drugbank.com/drugs/DB00585ApprovedA histamine H2 receptor antagonist with low toxicity that inhibits gastric acid secretion. The drug is used for the treatment of duodenal ulcers.
Categories: P-glycoprotein substratesSynonyms: N-(4-(6-Methylamino-7-nitro-2-thia-5-aza-6-hepten-1-yl)-2-thiazolylmethyl)-N,N-dimethylamine