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Afamelanotide
go.drugbank.com/drugs/DB04931ApprovedAfamelanotide is a first-in-class, synthetic, 13-amino acid peptide analogue of the endogenous alpha melanocyte-stimulating hormone (α-MSH). … [L9086] It differs structurally from its endogenous counterpart by only two amino acids - these structural differences improve biological efficacy by imparting a greater affinity for its target and a longer
Synonyms: MT-I, Melanotan 1Categories: Melanocortin 1 Receptor (MC1-R) Agonists, Compounds used in a research, industrial, or household settingPlasminogen
go.drugbank.com/drugs/DB16701ApprovedInvestigational[A236035] This pathway is activated when a clot is no longer needed or to prevent a clot from extending beyond the site of injury. … Plasminogen is a pro-enzyme (i.e. a zymogen) which is cleaved to form plasmin - also known as [fibrinolysin] - as part of the fibrinolytic pathway that breaks down fibrin blood clots.
Synonyms: 1-glutamylplasminogenBetaine
go.drugbank.com/drugs/DB06756ApprovedInvestigationalNutraceuticalIt is a naturally occurring choline derivative commonly ingested through diet, with a role in regulating cellular hydration and maintaining cell function. … Betaine is a methyl group donor that functions in the normal metabolic cycle of methionine.
Synonyms: 2-N,N,N-trimethylammonio acetate, N,N,N-TrimethylglycineMixtures: Ultr F/b E.S. Mega Lipotropic Fmla W B6bet, KORDEL`S NUTRITIME TABLETDextrose, unspecified form
go.drugbank.com/drugs/DB09341ApprovedInvestigationalVet approvedL-glucose is a synthesized enantiomer that is used as a low-calorie sweetener and laxative. … Glucose is a simple sugar (monosaccharide) generated during phosynthesis involving water, carbon and sunlight in plants.
Mixtures: %5 DEKSTROZ %02 NACL PVC 250 ML(SETLI), %5 DEKSTROZ %02 NACL PVC 500 ML(SETLI)Categories: Compounds used in a research, industrial, or household setting2-Methoxyestradiol
go.drugbank.com/drugs/DB02342Investigational2-Methoxyestradiol (2ME2) is a drug that prevents the formation of new blood vessels that tumors need in order to grow (angiogenesis). … It has undergone Phase 1 clinical trials against breast cancers and preclinical studies suggest that 2ME2 could also be effective against inflammatory diseases such as rheumatoid arthritis.
Synonyms: 2-Hydroxyestradiol 2-methyl ether, 2-Hydroxyestradol 2-methyl etherBupivacaine
go.drugbank.com/drugs/DB00297ApprovedInvestigationalBupivacaine is a widely used local anesthetic agent.
Mixtures: Mlp A-2, Mlp A-1Categories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP3A SubstratesTepotinib
go.drugbank.com/drugs/DB15133ApprovedInvestigationalTepotinib is a MET tyrosine kinase inhibitor intended to treat a variety of MET-overexpressing solid tumors. … [A228058] MET is a desirable target in the treatment of certain solid tumors as it appears to play a critical role, both directly and indirectly, in the growth and proliferation of tumors in which it is
Categories: MATE 1 Inhibitors, MATE 2 InhibitorsUbrogepant
go.drugbank.com/drugs/DB15328ApprovedInvestigational[L10959] Several oral small molecule CGRP receptor antagonists, belonging to a class of medications referred to as "gepants", have been investigated for migraines, but only ubrogepant and [rimegepant] … [A189207,A189213] Previous agents within this class were efficacious but limited by liver toxicity - this led to the development of ubrogepant, which was designed to be a hepatoxicity-free alternative
Categories: P-glycoprotein substrates, Cytochrome P-450 SubstratesAvasopasem manganese
go.drugbank.com/drugs/DB16354InvestigationalAvasopasem manganese, also known as GC4419, is a highly-selective small molecule mimetic of superoxide dismutase (SOD) being investigated for the reduction of radiation-induced severe oral mucositis.
Cardiolipin Biosynthesis CL(16:0/18:0/18:0/18:0)
smpdb.ca/view/SMP0027115MetabolicCardiolipin (CL) is an important component of the inner mitochondrial membrane where it constitutes about 20% of the total lipid composition. It is essential for the optimal function of numerous enzymes that are involved in mitochondrial...