Tepotinib
This drug entry is a stub and has not been fully annotated. It is scheduled to be annotated soon.
Identification
- Name
- Tepotinib
- Accession Number
- DB15133
- Description
Tepotinib is under investigation in clinical trial NCT03531762 (Effect of a Proton Pump Inhibitor on the Pharmacokinetics (PK) of Tepotinib).
- Type
- Small Molecule
- Groups
- Investigational
- Structure
Structure for Tepotinib (DB15133)
- Weight
- Average: 492.583
Monoisotopic: 492.227374166 - Chemical Formula
- C29H28N6O2
- Synonyms
- Not Available
Pharmacology
- Indication
- Not Available
- Contraindications & Blackbox Warnings
Learn about our commercial Contraindications & Blackbox Warnings data.
Learn More- Pharmacodynamics
- Not Available
- Mechanism of action
- Not Available
- Absorption
- Not Available
- Volume of distribution
- Not Available
- Protein binding
- Not Available
- Metabolism
- Not Available
- Route of elimination
- Not Available
- Half-life
- Not Available
- Clearance
- Not Available
- Adverse Effects
Learn about our commercial Adverse Effects data.
Learn More- Toxicity
- Not Available
- Affected organisms
- Not Available
- Pathways
- Not Available
- Pharmacogenomic Effects/ADRs
- Not Available
Interactions
- Drug Interactions
- This information should not be interpreted without the help of a healthcare provider. If you believe you are experiencing an interaction, contact a healthcare provider immediately. The absence of an interaction does not necessarily mean no interactions exist.Not Available
- Food Interactions
- Not Available
Categories
- Drug Categories
- Not Available
- Classification
- Not classified
Chemical Identifiers
- UNII
- 1IJV77EI07
- CAS number
- 1100598-32-0
- InChI Key
- AHYMHWXQRWRBKT-UHFFFAOYSA-N
- InChI
- InChI=1S/C29H28N6O2/c1-34-12-10-21(11-13-34)20-37-26-17-31-29(32-18-26)25-7-3-5-23(15-25)19-35-28(36)9-8-27(33-35)24-6-2-4-22(14-24)16-30/h2-9,14-15,17-18,21H,10-13,19-20H2,1H3
- IUPAC Name
- 3-{1-[(3-{5-[(1-methylpiperidin-4-yl)methoxy]pyrimidin-2-yl}phenyl)methyl]-6-oxo-1,6-dihydropyridazin-3-yl}benzonitrile
- SMILES
- CN1CCC(COC2=CN=C(N=C2)C2=CC(CN3N=C(C=CC3=O)C3=CC(=CC=C3)C#N)=CC=C2)CC1
References
- General References
- Not Available
- External Links
- ChemSpider
- 28637823
- BindingDB
- 50065457
- ChEMBL
- CHEMBL3402762
- ZINC
- ZINC000043202335
- PDBe Ligand
- 3E8
- Wikipedia
- C-Met_inhibitor
- PDB Entries
- 4r1v
Clinical Trials
- Clinical Trials
Phase Status Purpose Conditions Count 2 Not Yet Recruiting Treatment Neoplasms, Colorectal 1 2 Recruiting Treatment Advanced (Stage IIIB/IV) Non-small Cell Lung Cancer With MET Exon 14 (METex14) Skipping Alterations or MET Amplification 1 2 Recruiting Treatment MET Amplification / MET exon 14 skipping mutation / Tumors, Solid 1 2 Recruiting Treatment Non-Small Cell Lung Carcinoma (NSCLC) 1 1 Completed Other Healthy Volunteers 5 1 Completed Other Hepatic Impairment 1 1 Completed Treatment Healthy Volunteers 1 1 Completed Treatment Patients With Solid Tumors, Either Refractory to Standard Therapy or for Which no Effective Standard Therapy is Available 1 1, 2 Active Not Recruiting Treatment Hepatocellular Carcinoma 1 1, 2 Active Not Recruiting Treatment Non-Small Cell Lung Carcinoma (NSCLC) 1
Pharmacoeconomics
- Manufacturers
- Not Available
- Packagers
- Not Available
- Dosage Forms
- Not Available
- Prices
- Not Available
- Patents
- Not Available
Properties
- State
- Not Available
- Experimental Properties
- Not Available
- Predicted Properties
Property Value Source Water Solubility 0.00999 mg/mL ALOGPS logP 3.64 ALOGPS logP 4 ChemAxon logS -4.7 ALOGPS pKa (Strongest Basic) 9.13 ChemAxon Physiological Charge 1 ChemAxon Hydrogen Acceptor Count 7 ChemAxon Hydrogen Donor Count 0 ChemAxon Polar Surface Area 94.71 Å2 ChemAxon Rotatable Bond Count 7 ChemAxon Refractivity 154.74 m3·mol-1 ChemAxon Polarizability 54 Å3 ChemAxon Number of Rings 5 ChemAxon Bioavailability 1 ChemAxon Rule of Five Yes ChemAxon Ghose Filter No ChemAxon Veber's Rule No ChemAxon MDDR-like Rule Yes ChemAxon - Predicted ADMET Features
- Not Available
Spectra
- Mass Spec (NIST)
- Not Available
- Spectra
- Not Available
Drug created on May 20, 2019 08:52 / Updated on June 12, 2020 10:53