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Displaying results 111 - 120 of 10000 in total
  1. Drug

    Mesalazine

    go.drugbank.com/drugs/DB00244
    ApprovedInvestigational

    Although demonstrably effective in treating and maintaining remission for ulcerative colitis, mesalazine has historically faced a number of issues regarding its lack of stability as a pharmaceutical agent … Throughout the late seventies and the eighties, important research initiatives developed stable mesalazine formulations like the eudragit-S coating of Asacol brand mesalazine and the Pentasa brand's encapsulation

    Synonyms: m-Aminosalicylic acid, 3-carboxy-4-hydroxyanilineProducts: MESALAZINA TABLETA RECUBIERTA X 500 MG, SALOFALK 250 TABLET 250 mg
  2. Drug

    Zidovudine

    go.drugbank.com/drugs/DB00495
    ApprovedInvestigational

    A dideoxynucleoside compound in which the 3'-hydroxy group on the sugar moiety has been replaced by an azido group. … The compound is a potent inhibitor of HIV replication, acting as a chain-terminator of viral DNA during reverse transcription.

    Mixtures: LAMIVUDINA 150 MG + ZIDOVUDINA 300 MG + NEVIRAPINA 200 MG TABLETAS CUBIERTAS, LAMIVUDINA 150 MG + ZIDOVUDINA 300 MG + NEVIRAPINA 200 MG TABLETAS CUBIERTASCategories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP3A Substrates
  3. Drug

    Zuclopenthixol

    go.drugbank.com/drugs/DB01624
    ApprovedInvestigational

    Known drug targets of zuclopenthixol include 5-hydroxytryptamine receptor 2A, D(1B) dopamine receptor, D(2) dopamine receptor, D(1A) dopamine receptor, and alpha-1A adrenergic receptor. … These are organic polycyclic compounds containing a thioxanthene moiety, which is an aromatic tricycle derived from xanthene by replacing the oxygen atom with a sulfur atom.

    Categories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP3A SubstratesSynonyms: (Z)-4-(3-(2-Chlorothioxanthen-9-ylidene)propyl)-1-piperazineethanol
  4. Drug

    Tranexamic acid

    go.drugbank.com/drugs/DB00302
    ApprovedInvestigational

    It possesses a similar mechanism of action to [aminocaproic acid] but is approximately 10-fold more potent. … Tranexamic acid is a synthetic derivative of [lysine] used as an antifibrinolytic in the treatment and prevention of major bleeding.

    Synonyms: trans-4-aminomethylcyclohexane-1-carboxylic acid, trans-4-(Aminomethyl)cyclohexanecarboxylic acidInternational brands: Cyclo-F
  5. Drug

    Cephalexin

    go.drugbank.com/drugs/DB00567
    ApprovedInvestigationalVet approved

    [A179071,A179074] This antibiotic contains a beta lactam and a dihydrothiazide. … [A179071] Cephalexin is used to treat a number of susceptible bacterial infections through inhibition of cell wall synthesis.[A179083,L6547] Cephalexin was approved by the FDA on 4 January 1971.

    Synonyms: (6R,7R)-7-{[(2R)-2-amino-2-phenylacetyl]amino}-3-methyl-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid, 7-beta-(D-alpha-Amino-alpha-phenylacetylamino)-3-methyl-3-cephem-4-carboxylic acidInternational brands: L-Keflex
  6. Drug

    Potassium chloride

    go.drugbank.com/drugs/DB00761
    ApprovedInvestigationalWithdrawn

    The FDA withdrew its approval for the use of all solid oral dosage form drug products containing potassium chloride that supply 100 mg or more of potassium per dosage unit, except for controlled-release … A white crystal or crystalline powder used as an electrolyte replenisher, in the treatment of hypokalemia, in buffer solutions, and in fertilizers and explosives.

    Mixtures: SODIO60 MCG +POTASIO 20 MCG + CLORURO 50 MCG + CITRATO 30 MG + GLUCOSA111 MCG, Selectbag One (ax 250 G)International brands: Slow-K, Micro-K
  7. Drug

    Hepatitis B immune globulin

    go.drugbank.com/drugs/DB05276
    ApprovedInvestigational

    Long-term hepatitis B immune globulin (HBIG) has been shown to reduce hepatitis B virus (HBV) reinfection in patients transplanted for hepatitis B. … Infection with hepatitis B may lead to hepatocellular carcinoma, a type of liver cancer. Therefore, the hepatitis-B vaccines are cancer-preventing vaccines.

    Synonyms: Hepatitis B immune globulin, Hepatitis B immune globulin humanCategories: hepatitis B immunoglobulin
  8. Drug

    Acetylsalicylic acid

    go.drugbank.com/drugs/DB00945
    ApprovedInvestigationalVet approved

    This drug also inhibits platelet aggregation and is used in the prevention of blood clots stroke, and myocardial infarction (MI) [FDA label]. … Also known as _Aspirin_, acetylsalicylic acid (ASA) is a commonly used drug for the treatment of pain and fever due to various causes.

    Synonyms: 2-Acetoxybenzoic acid, o-acetoxybenzoic acidMixtures: COD-C 500/250 MG EFERVESAN TABLET, 20 ADET, THOMAPVRIN 250 mg/200 mg/50 mg TABLET, 20 ADET
  9. Drug

    Pudexacianinium

    go.drugbank.com/drugs/DB19161
    Investigational

    Pudexacianinium is under investigation in clinical trial NCT05754333 (A Study to Find Out if ASP5354 Can Clearly Help Show the Ureter During Surgery).

    Synonyms: )ETHYLIDENE)-2-METHOXYCYCLOHEX-1-EN-1-YL)ETHEN-1-Y, )-1,1-dimethyl-1h-benz(e)indolium ion
  10. Drug

    Hydroxyprogesterone caproate

    go.drugbank.com/drugs/DB06789
    Approved

    Hydroxyprogesterone caproate was previously marketed under the trade name Delalutin by Squibb, which was approved by the U.S. … FDA approved Makena from KV Pharmaceutical (previously named as Gestiva) on February 4, 2011 for prevention of preterm delivery in women with a history of preterm delivery, sparking a pricing controversy

    Mixtures: GRAVIDINONA 2 MLCategories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP2C19 Inducers