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Isotretinoin
go.drugbank.com/drugs/DB00982ApprovedInvestigational[Label] It was most widely marketed under the brand name Accutane, which has since been discontinued.
Products: ISOTRETINOINA EG, ISODERM 10MGZonisamide
go.drugbank.com/drugs/DB00909ApprovedInvestigationalIn 1989, it was approved for commercial use in Japan. The US and Europe approved it in 2000 and 2005, respectively.[A1379,A1383] … [L42530,L42535] Zonisamide may act by blocking repetitive firing of voltage-gated sodium channels, leading to a reduction of T-type calcium channel currents or by binding allosterically to GABA receptors
Products: ZONISOL 20MG/ML SUE, ZONEGRAN 100MGPravastatin
go.drugbank.com/drugs/DB00175ApprovedInvestigationalIt was the first statin administered as the active form and not as a prodrug.[T274] This drug was developed by Sankyo Co.
Mixtures: Pravafen 40mg/160mg Hard Capsules, PRAVAFEN HARD CAPSULES 40mg/160mgProducts: PRAVASTATIN HEU 10MG NET, PRAVASTATIN - CT 10MG TABLBismuth subgallate
go.drugbank.com/drugs/DB13909Approvedinternal deodorant where it is often employed as the primary active ingredient. … It is a heavy metal salt of gallic acid that is highly insoluble and poorly absorbed.
Products: Devrom Chew Tab 200mgLamivudine
go.drugbank.com/drugs/DB00709ApprovedInvestigationalIt is used to treat Human Immunodeficiency Virus Type 1 (HIV-1) and hepatitis B (HBV).
Mixtures: Zidovex LN (Lamivudine 150mg, Zidovudine 300mg, Nevirapine 200mg Tablets), TRIUMEQ FILM COATED TABLET 50mg/600mg/300mgProducts: Lamivox 10mg/ml (Lamivudine Oral Solution 10mg/ml), 3TC ORAL SOLUTION 10MG/MLLeucovorin
go.drugbank.com/drugs/DB00650ApprovedInvestigational[L56092, A257419] Unlike folic acid, leucovorin does not require the enzyme dihydrofolate reductase (DHFR) for activation, allowing it to function even when DHFR is inhibited by drugs like methotrexate … [A275451] It is primarily indicated for "leucovorin rescue" to diminish the hematologic and mucosal toxicity of high-dose methotrexate therapy in osteosarcoma and to treat inadvertent overdoses of folic
Products: BENDAFOLIN 10MG/ML 200MG, LEUCOVORIN 10MG/ML 30MGButylscopolamine
go.drugbank.com/drugs/DB09300ApprovedInvestigationalVet approvedIt is used to treat pain and discomfort caused by abdominal cramps, menstrual cramps, or other spasmodic activity in the digestive system. It is also effective at preventing bladder spasms. … It is not a pain medication in the normal sense, since it does not directly affect pain, but rather works to prevent painful cramps and spasms from occurring.
Mixtures: ACETAMINOFEN 325 MG + N-BUTILBROMURO DE HIOSCINA 10MG TABLETAS, ACETAMINOFEN 325 MG + N-BUTILBROMURO DE HIOSCINA 10MG TABLETASProducts: BUSTON INJECTION 20MG/ML, Uscine Tablets 10mgAlpelisib
go.drugbank.com/drugs/DB12015ApprovedInvestigationalAlpelisib was designed to target this enzyme that appears to be mutated at a rate of nearly 30% in human cancers, leading to hyperactivation. … It works by selectively inhibiting class I PI3K p110α [A179203], which is the catalytic subunit of PI3K, a lipid kinase that plays a role in various biological processes, including proliferation, survival
Products: PIQRAY 250MG DAILY DOSE PACK (200mg + 50mg), PIQRAY 200MG DAILY DOSE PACKLovastatin
go.drugbank.com/drugs/DB00227ApprovedInvestigational[A181397, A181403] While all statin medications are considered equally effective from a clinical standpoint, [rosuvastatin] is considered the most potent; doses of 10 to 40mg [rosuvastatin] per day
Products: LOVASTATINA EG, LOVAHEXAL 10MG TABLHydrochlorothiazide
go.drugbank.com/drugs/DB00999ApprovedInvestigationalVet approved[A185138] It is indicated to treat edema and hypertension.[A185138,L8447,L8450] Hydrochlorothiazide use is common but declining in favour of angiotensin converting enzyme inhibitors.
Mixtures: Exforge HCT Tablet 10mg/160mg/25mg, ENABETA COMP 10MG/25MGProducts: HCT - CT 25MG, Hydrodiuril Tab 100mg