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Lacidipine
go.drugbank.com/drugs/DB09236ApprovedDue to its long duration of action, lacidipine does not lead to reflex tachycardia [A31536]. … Lacidipine is a lipophilic dihydropyridine calcium antagonist with an intrinsically slow onset of activity.
Categories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP3A SubstratesPolymyxin B
go.drugbank.com/drugs/DB00781ApprovedInvestigationalVet approvedPolymyxin B was discovered in the 1940s . They are basic polypeptides of about eight amino acids and have cationic detergent action on cell membranes . Polymyxin B is used for infections with gram-negative organisms, but may be neurotoxi...
Mixtures: OTEK-P EAR DROPS, PS-2261 Triple Antibiotic, 0.5gProducts: POLİX 500000 IU ENJEKSİYONLUK ÇÖZELTİ HAZIRLAMAK İÇİN LİYOFİLİZE TOZ (POLİMİSİN), 10 FLAKON, POLİX 500000 IU ENJEKSİYONLUK ÇÖZELTİ HAZIRLAMAK İÇİN LİYOFİLİZE TOZ (POLİMİSİN), 1 FLAKONFinerenone
go.drugbank.com/drugs/DB16165ApprovedInvestigationalmineralocorticoid receptor antagonist indicated to reduce the risk of sustained decline in glomerular filtration rate, end stage kidney disease, cardiovascular death, heart attacks, and hospitalization due … [A236544] Spironolactone has low selectivity and affinity for the receptor; it dissociates quickly and can also have effects at the androgen, progesterone, and glucocorticoid receptors.
Categories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP1A1 SubstratesTick-borne encephalitis vaccine (whole virus, inactivated)
go.drugbank.com/drugs/DB16611ApprovedInvestigational[A237520] Due to a paucity of effective safe and effective acute therapeutic agents, vaccination remains the most important defence against TBE in endemic areas. … [A237505, A237520] While some patients recover fully following neurological TBE, neurological sequelae can last for years and rare chronic forms of the disease have also been noted.
Unstable Angina Pectoris
go.drugbank.com/conditions/DBCOND0032056Synonyms: Angina at rest, (Angina: [crescendo] or [unstable] or [at rest]) or (preinfarction syndrome) or (impending infarction)Miltefosine
go.drugbank.com/drugs/DB09031ApprovedInvestigationalIt can be administered topically or orally and is only indicated in patients aged 12 years or older. … Miltefosine is a broad spectrum antimicrobial, anti-leishmanial, phospholipid drug that was originally developed in the 1980s as an anti-cancer agent.
Categories: P-glycoprotein substratesMicafungin
go.drugbank.com/drugs/DB01141ApprovedInvestigationalIt belongs to the antifungal class of compounds known as echinocandins and exerts its effect by inhibiting the synthesis of 1,3-beta-D-glucan, an integral component of the fungal cell wall. … Micafungin is an antifungal drug.
Bioallethrin
go.drugbank.com/drugs/DB13746ApprovedWithdrawnA mixture of the two same stereoisomers, but in an approximate ratio of R:S in 1:3, is called esbiothrin. … Bioallethrin refers to a mixture of two of the allethrin isomers (1R,trans;1R and 1R,trans;1S) in an approximate ratio of 1:1, where both isomers are active ingredients.
Categories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP3A SubstratesCamizestrant
go.drugbank.com/drugs/DB19218ApprovedInvestigational[L64094,L64107] In pre- or peri-menopausal women and in men, camizestrant plus a CDK4/6 inhibitor is combined with an LHRH agonist or antagonist. … Camizestrant is an oral selective estrogen receptor degrader (SERD) and estrogen receptor (ER) antagonist used in combination with a CDK4/6 inhibitor to treat hormone receptor-positive, HER2-negative locally
Categories: P-glycoprotein inhibitors, P-glycoprotein substratesAbiraterone
go.drugbank.com/drugs/DB05812ApprovedInvestigationalAbiraterone is a potent, irreversible, and selective inhibitor of 17 αhydroxylase/C17,20-lyase (CYP17), an enzyme expressed in testicular, adrenal, and prostatic tumour tissues, to regulate androgen biosynthesis … [L54773,L54768] As abiraterone has poor oral bioavailability and is susceptible to hydrolysis by esterases, abiraterone acetate was developed as an orally bioavailable prodrug with enhanced stability
Categories: P-glycoprotein inhibitors, Cytochrome P-450 Substrates