Molsidomine is a long-acting vasodilator used to treat angina pectoris, including in association with left heart failure and acute myocardial infarction. Molsidomine is an orally active, long-acting vasodilator, which belongs to the class of medications known as syndnones.
- Mechanism
- Curator reviewed
Molsidomine, a cardiovascular drug, acts in a similar fashion to organic nitrates. The SIN-1A metabolite of molsidomine has a pharmacologically active group of nitric oxide, which increases levels of cyclic GMP, and decreases intracellular calcium ions in smooth muscle cells. This leads to relaxation of smooth muscle in the blood vessels, and inhibits platelet aggregation.
- Primary indication
- The indications for use of molsidomine include ischemic heart disease, angina, chronic heart failure, and pulmonary hypertension.Curator reviewed · 5 structured indications
- Formula / weight
- C9H14N4O4 · 242.235 g/mol (avg)
- Code names
- CAS-276 · SIN-10
Resolves to
XLFWDASMENKTKL-UHFFFAOYSA-NSMILESCCOC(=O)[N-]C1=C[N+](=NO1)N1CCOCC1What you can answer from here — as of September 23, 2026
Which drugs share a target with Molsidomine, and which of those have an active Phase 3 trial?
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