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Displaying results 1241 - 1250 of 10000 in total
  1. Drug

    Riociguat

    go.drugbank.com/drugs/DB08931
    ApprovedInvestigational

    Riociguat is a soluble guanylate cyclase (sGC) agonist approved in the USA, Europe and several other regions for patients with group I PAH (pulmonary arterial hypertension) in WHO FC II or III; and for … Riociguat is marketed under the brand Adempas® by Bayer HealthCare Pharmaceuticals. Treatment with riociguat costs USD $7,500 for 30 days of treatment.

    Categories: P-glycoprotein substrates, Cytochrome P-450 SubstratesSynonyms: Methyl N-[4,6-Diamino-2-[1-[(2-fluorophenyl)methyl]-1H-pyrazolo[3,4-b]pyridin-3-yl]-5-pyrimidinyl]-N-methyl-carbaminate
  2. Drug

    DL-alpha tocopheryl acetate

    go.drugbank.com/drugs/DB14477
    Approved

    Mixtures: Se-Natal, Se-Natal 19Categories: Vitamin E
  3. Drug

    Methylene blue

    go.drugbank.com/drugs/DB09241
    ApprovedInvestigational

    Methylene blue is an oxidation-reduction agent. The intravenous form of methylene blue is approved by the FDA for the treatment of pediatric and adult patients with acquired methemoglobinemia. … The drug is of potential interest for the treatment of patients with Alzheimer's disease.

    Mixtures: Me NaPhos MB Hyo 1, Urin D/SCategories: Serotonergic Drugs Shown to Increase Risk of Serotonin Syndrome, MATE 1 Inhibitors
  4. Drug

    Butobarbital

    go.drugbank.com/drugs/DB01353
    ApprovedIllicit

    Butobarbital is a sedative and a hypnotic drug.

    Categories: Heterocyclic Compounds, 1-Ring
  5. Drug

    Tibolone

    go.drugbank.com/drugs/DB09070
    ApprovedInvestigational

    It has been used in Europe for almost 2 decades, primarily for the prevention of postmenopausal osteoporosis and the treatment of post-menopausal symptoms [L1720]. … In June 2006, Organon Pharmaceuticals announced the receipt of a Not Approvable Letter from the U.S.

    Categories: Sex Hormones and Modulators of the Genital SystemSynonyms: 17-hydroxy-7alpha-methyl-19-nor-17alpha-pregn-5(10)-en-20-yn-3-one
  6. Drug

    Doconexent

    go.drugbank.com/drugs/DB03756
    ApprovedInvestigational

    It is an omega-3 fatty acid and primary structural component of the human brain, cerebral cortex, skin, and retina thus plays an important role in their development and function. … The amino-phospholipid DHA is found at a high concentration across several brain subcellular fractions, including nerve terminals, microsomes, synaptic vesicles, and synaptosomal plasma membranes [A19436

    Mixtures: Se-Tan DHA, Se-Plete DHACategories: Fatty Acids, Omega-3, Cytochrome P-450 Substrates
  7. Drug

    Pentobarbital

    go.drugbank.com/drugs/DB00312
    ApprovedVet approved

    It is prescribed more frequently for sleep induction than for sedation but, like similar agents, may lose its effectiveness by the second week of continued administration. … A short-acting barbiturate that is effective as a sedative and hypnotic (but not as an anti-anxiety) agent and is usually given orally.

    Categories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP2A6 InducersSynonyms: 5-Ethyl-5-(1-methyl-butyl)-pyrimidine-2,4,6-trione, 5-ethyl-5-(1-methylbutyl)barbituric acid
  8. Drug

    Furosemide

    go.drugbank.com/drugs/DB00695
    ApprovedInvestigationalVet approved

    Furosemide is a potent loop diuretic that acts on the kidneys to ultimately increase water loss from the body. It is an anthranilic acid derivative. … In addition to oral formulations, the solution for intravenous and intramuscular administration is also available, which is typically limited to patients who are unable to take oral medication or for patients

    Mixtures: SPIRO D TABLINEN 100MG, Lasitace 5 mg/40 mg KapselnSynonyms: 4-Chloro-N-(2-furylmethyl)-5-sulfamoylanthranilic acid, 2-Furfurylamino-4-chloro-5-sulfamoylbenzoic acid
  9. Drug

    Anileridine

    go.drugbank.com/drugs/DB00913
    ApprovedIllicitWithdrawn

    Anileridine is a synthetic opioid and strong analgesic medication. It is a narcotic pain reliever used to treat moderate to severe pain. … Narcotic analgesics act in the central nervous system (CNS) to relieve pain. Some of their side effects are also caused by actions in the CNS.

    Categories: Heterocyclic Compounds, 1-RingSynonyms: 1-[2-(4-aminophenyl)ethyl]-4-phenyl-4-piperidinecarboxlic acid ethyl ester, ethyl 1-(2-(4-aminophenyl)ethyl)-4-phenyl-4-piperidinecarboxylate
  10. Drug

    Tezacaftor

    go.drugbank.com/drugs/DB11712
    ApprovedInvestigational

    Tezacaftor is a drug of the cystic fibrosis transmembrane conductance regulator (CFTR) corrector class. … [A20298,A20299] As a result, CF patients produce thick, sticky mucus that clogs the ducts of organs where it is produced making patients more susceptible to complications such as infections, lung damage

    Categories: P-glycoprotein inhibitors, P-glycoprotein substrates