DL-alpha tocopheryl acetate

Identification

Brand Names

Mvi Pediatric, Natafort

Generic Name

DL-alpha tocopheryl acetate

DrugBank Accession Number

DB14477

Background

Not Available

Type

Small Molecule

Groups

Approved, Experimental

Structure

3D

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MOLSDF3D-SDFPDBSMILESInChI

Similar Structures

Structure for DL-alpha tocopheryl acetate (DB14477)

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Weight

Average: 472.754
Monoisotopic: 472.391645534

Chemical Formula

C₃₁H₅₂O₃

Synonyms

• all-rac-alfa-tocopheryl acetate
• all-rac-alpha-tocopheryl acetate
• DL-alpha-tocopheryl acetate

Pharmacology

Indication

Not Available

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Associated Conditions

• Degenerative Retinal Disorders
• Eye degenerative disorder
• Vitamin Deficiency
• Vitamin E Deficiency

Contraindications & Blackbox Warnings

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Pharmacodynamics

Not Available

Mechanism of action

Not Available

Absorption

Not Available

Volume of distribution

Not Available

Protein binding

Not Available

Metabolism

Not Available

Route of elimination

Not Available

Half-life

Not Available

Clearance

Not Available

Adverse Effects

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Toxicity

Not Available

Pathways

Not Available

Pharmacogenomic Effects/ADRs

Not Available

Interactions

Drug Interactions

This information should not be interpreted without the help of a healthcare provider. If you believe you are experiencing an interaction, contact a healthcare provider immediately. The absence of an interaction does not necessarily mean no interactions exist.

• Approved
• Vet approved
• Nutraceutical
• Illicit
• Withdrawn
• Investigational
• Experimental
• All Drugs

Drug	Interaction
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Orlistat	Orlistat can cause a decrease in the absorption of DL-alpha tocopheryl acetate resulting in a reduced serum concentration and potentially a decrease in efficacy.

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Food Interactions

No interactions found.

Products

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Active Moieties

Name	Kind	UNII	CAS	InChI Key
Vitamin E	prodrug	N9PR3490H9	59-02-9	GVJHHUAWPYXKBD-IEOSBIPESA-N
DL-alpha-Tocopherol	prodrug	7QWA1RIO01	10191-41-0	GVJHHUAWPYXKBD-UHFFFAOYSA-N

Product Images

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Over the Counter Products

Name	Dosage	Strength	Route	Labeller	Marketing Start	Marketing End	Region	Image
Aquasol E Drops 50unit/ml	Solution / drops	50 unit / mL	Oral	Rhone Poulenc Rorer	1993-12-31	1997-08-13
E Vitamin 200I.U. (synthetic Source) - Cap	Capsule	200 unit / cap	Oral	H.J. Sutton Industries Ltd.	1996-10-25	1998-08-31
E Vitamin 400 I.U. (synthetic Source)-cap	Capsule	400 unit / cap	Oral	H.J. Sutton Industries Ltd.	1996-10-25	1998-08-31
E Vitamin 800I.U.(synthetic Source)-cap	Capsule	800 unit / cap	Oral	H.J. Sutton Industries Ltd.	1996-10-25	1998-08-31
Vitamin E 200iu With Non-med.odorless Garlic	Capsule	200 unit / cap	Oral	Pharmavite	1996-09-06	2003-07-30
Vitamin E Cap 200unit	Capsule	200 unit / cap	Oral	Stanley Pharmaceuticals, A Division Of Vita Health Products Inc.	1973-12-31	2002-07-31
Vitamin E Cap 400iu	Capsule	400 unit / cap	Oral	Stanley Pharmaceuticals, A Division Of Vita Health Products Inc.	1973-12-31	2002-07-31
Vitamin E Capsule 400unit USP	Capsule	400 unit / cap	Oral	Jamieson Laboratories Ltd	1993-12-31	1997-08-13
Vitamin E Capsules - 400 I.U.	Capsule	400 unit / cap	Oral	General Nutrition Canada Inc.	1997-09-16	2005-08-05
Vitamin E Capsules 1000I.U. USP	Capsule	1000 unit / cap	Oral	Vita Health Products Inc	1995-12-31	2008-08-05

Mixture Products

Name	Ingredients	Dosage	Route	Labeller	Marketing Start	Marketing End	Region	Image
A/o-26 - Caplet	DL-alpha tocopheryl acetate (100 unit) + Beta carotene (7500 unit) + Calcium (75 mg) + Calcium ascorbate (250 mg) + Copper (1 mg) + Folic acid (.4 mg) + Manganese (2.5 mg) + Racemethionine (50 mg) + Selenium (100 mcg) + Zinc (7.5 mg)	Tablet	Oral	Enviro Tech International Canada	1996-12-19	1999-07-26
Balance Ace - Cap	DL-alpha tocopheryl acetate (200 unit) + Ascorbic acid (250 mg) + Beta carotene (10000 unit) + Cupric oxide (1 mg) + Manganese sulfate (1.5 mg) + Sodium selenate (15 mcg) + Zinc oxide (7.5 mg)	Capsule	Oral	Pharmavite	1996-09-06	2002-07-25
Beta C and E Tab	DL-alpha tocopheryl acetate (200 unit / tab) + Ascorbic acid (250 mg / tab) + Beta carotene (5000 unit / tab)	Tablet	Oral	Ksl Pharmaceuticals	1994-12-31	1997-08-08
Betacept Special Formula Vitamins Cap	DL-alpha tocopheryl acetate (200 unit / cap) + Ascorbic acid (250 mg / cap) + Beta carotene (10000 unit / cap)	Capsule	Oral	Wampole Brands, A Division Of Pangeo Pharma (Canada) Inc.	1993-12-31	2002-07-29
Children's Chew Multi & Min Tab	DL-alpha tocopheryl acetate (15 unit / tab) + Ascorbic acid (30 mg / tab) + Beta carotene (1250 unit / tab) + Biotin (75 mcg / tab) + Calcium carbonate (100 mg / tab) + Choline bitartrate (5 mg / tab) + Copper gluconate (1 mg / tab) + Cyanocobalamin (5 mcg / tab) + Ferrous gluconate (2.5 mg / tab) + Iodine (.075 mg / tab) + Magnesium oxide (25 mg / tab) + Manganese gluconate (.5 mg / tab) + Nicotinamide (10 mg / tab) + Calcium pantothenate (6.25 mg / tab) + Potassium chloride (.5 mg / tab) + Potassium chloride (5 mg / tab) + Pyridoxine hydrochloride (1.25 mg / tab) + Riboflavin (1.25 mg / tab) + Thiamine hydrochloride (1.25 mg / tab) + Vitamin A palmitate (1250 unit / tab) + Vitamin D (200 unit / tab) + Zinc gluconate (1.25 mg / tab)	Tablet	Oral	Natrol, Inc.	1995-12-31	2001-07-30
Childrens Chewable Multiple Vitamins W.iron	DL-alpha tocopheryl acetate (15 unit / tab) + Ascorbic acid (60 mg / tab) + Cyanocobalamin (4.5 mcg / tab) + Ferrous fumarate (4 mg / tab) + Folic acid (.3 mg / tab) + Nicotinamide (13.5 mg / tab) + Pyridoxine hydrochloride (1.05 mg / tab) + Riboflavin (1.2 mg / tab) + Thiamine mononitrate (1.05 mg / tab) + Vitamin A acetate (2500 unit / tab) + Vitamin D (400 unit / tab)	Tablet	Oral	Pharmavite	1995-12-31	2000-08-24
Fizz Multivitamins for Kids W C Loz	DL-alpha tocopheryl acetate (15 unit / loz) + Ascorbic acid (250 mg / loz) + Cyanocobalamin (4.5 mcg / loz) + Folic acid (.3 mg / loz) + Nicotinamide (13.5 mg / loz) + Pyridoxine hydrochloride (1.05 mg / loz) + Riboflavin (1.2 mg / loz) + Thiamine mononitrate (1.05 mg / loz) + Vitamin A acetate (2500 unit / loz) + Vitamin D (400 unit / loz)	Lozenge	Oral	Stanley Pharmaceuticals, A Division Of Vita Health Products Inc.	1992-12-31	1997-08-08
Hand Sanitizer With Ve	DL-alpha tocopheryl acetate (1.5 g/100g) + Ethanol (62 g/100g)	Liquid	Topical	NINGBO JIANGBEI OCEAN STAR TRADING CO.,LTD	2014-10-08	Not applicable
Hand Sanitizer With Ve	DL-alpha tocopheryl acetate (1.5 g/100g) + Ethanol (62 g/100g)	Liquid	Topical	NINGBO JIANGBEI OCEAN STAR TRADING CO.,LTD	2014-10-08	Not applicable
Hand Sanitizer With Ve	DL-alpha tocopheryl acetate (1.5 g/100g) + Ethanol (62 g/100g)	Liquid	Topical	NINGBO JIANGBEI OCEAN STAR TRADING CO.,LTD	2014-10-08	Not applicable

Unapproved/Other Products

Name	Ingredients	Dosage	Route	Labeller	Marketing Start	Marketing End	Region	Image
Abavite	DL-alpha tocopheryl acetate (13.5 mg/1) + Ascorbic acid (60 mg/1) + Cholecalciferol (0.025 mg/1) + Ferrous sulfate (30 mg/1) + Folic acid (1 mg/1) + Magnesium oxide (25 mg/1) + Mecobalamin (0.5 mg/1) + Niacin (15 mg/1) + Calcium pantothenate (5 mg/1) + Potassium Iodide (0.25 mg/1) + Riboflavin (1.8 mg/1) + Thiamine mononitrate (1.6 mg/1) + Vitamin A palmitate (0.33 mg/1) + Zinc oxide (15 mg/1)	Tablet	Oral	ABACOS HEALTH	2021-03-31	Not applicable
Active FE	DL-alpha tocopheryl acetate (40 [iU]/1) + Ascorbic acid (160 mg/1) + Beta carotene (2100 [iU]/1) + Cholecalciferol (400 [iU]/1) + Cupric oxide (1 mg/1) + Cyanocobalamin (30 ug/1) + Folic acid (1250 ug/1) + Iron (75 mg/1) + Magnesium oxide (30 mg/1) + Nicotinamide (20 mg/1) + Pyridoxine hydrochloride (20 mg/1) + Riboflavin (4 mg/1) + Thiamine hydrochloride (4 mg/1) + Zinc oxide (20 mg/1)	Tablet	Oral	Gm Pharmaceuticals	2013-11-11	Not applicable
Bal-Care DHA	DL-alpha tocopheryl acetate (3 mg/1) + Ascorbic acid (120 mg/1) + Beta carotene (2850 [iU]/1) + Calcium carbonate (219 mg/1) + Cholecalciferol (840 [iU]/1) + Cupric oxide (2 mg/1) + Cyanocobalamin (.012 mg/1) + Folic acid (1 mg/1) + Iodine (.223 mg/1) + Iron sucrose (1.35 mg/1) + Magnesium oxide (25 mg/1) + Nicotinamide (20 mg/1) + Omega-3 fatty acids (430 mg/1) + Pyridoxine hydrochloride (50 mg/1) + Riboflavin (4 mg/1) + Sodium feredetate (25.65 mg/1) + Thiamine mononitrate (1.8 mg/1) + Zinc oxide (25 mg/1)	Kit	Oral	Pru Gen Pharmaceuticals	2012-05-01	Not applicable
Bal-Care DHA Essential	DL-alpha tocopheryl acetate (3 mg/1) + Ascorbic acid (120 mg/1) + Beta carotene (2850 [iU]/1) + Calcium carbonate (219 mg/1) + Cholecalciferol (840 [iU]/1) + Cupric oxide (2 mg/1) + Cyanocobalamin (.012 mg/1) + Folic acid (1 mg/1) + Iodine (.223 mg/1) + Iron sucrose (1.35 mg/1) + Magnesium oxide (25 mg/1) + Nicotinamide (20 mg/1) + Omega-3 fatty acids (374 mg/1) + Pyridoxine hydrochloride (50 mg/1) + Riboflavin (4 mg/1) + Sodium feredetate (25.65 mg/1) + Thiamine mononitrate (1.8 mg/1) + Zinc oxide (25 mg/1)	Kit	Oral	Pru Gen Pharmaceuticals	2012-05-01	Not applicable
Cavan Alpha	DL-alpha tocopheryl acetate (3 mg/1) + Ascorbic acid (120 mg/1) + Beta carotene (3000 [iU]/1) + Calcium carbonate (230 mg/1) + Cholecalciferol (800 [iU]/1) + Cupric oxide (2 mg/1) + Cyanocobalamin (12 ug/1) + Folic acid (1 mg/1) + Iodine (220 ug/1) + Iron (27 mg/1) + Magnesium oxide (25 mg/1) + Nicotinamide (20 mg/1) + Omega-3 fatty acids (300 mg/1) + Pyridoxine hydrochloride (50 mg/1) + Riboflavin (4 mg/1) + Thiamine mononitrate (1.8 mg/1) + Zinc oxide (25 mg/1)	Kit	Oral	Seton Pharmaceuticals	2010-07-01	2013-09-30
Cavan Folate DHA	DL-alpha tocopheryl acetate (30 [iU]/1) + DL-alpha tocopheryl acetate (30 [iU]/1) + Ascorbic acid (70 mg/1) + Ascorbic acid (70 mg/1) + Beta carotene (2700 [iU]/1) + Beta carotene (2700 [iU]/1) + Calcium carbonate (100 mg/1) + Calcium carbonate (100 mg/1) + Cholecalciferol (400 [iU]/1) + Cholecalciferol (400 [iU]/1) + Cupric oxide (2 mg/1) + Cupric oxide (2 mg/1) + Cyanocobalamin (12 ug/1) + Cyanocobalamin (12 ug/1) + Doconexent (250 mg/1) + Doconexent (250 mg/1) + Ferrous fumarate (65 mg/1) + Ferrous fumarate (65 mg/1) + Folic acid (1 mg/1) + Folic acid (1 mg/1) + Magnesium oxide (25 mg/1) + Magnesium oxide (25 mg/1) + Nicotinamide (18 mg/1) + Nicotinamide (18 mg/1) + Pyridoxine hydrochloride (2.5 mg/1) + Pyridoxine hydrochloride (2.5 mg/1) + Riboflavin (1.8 mg/1) + Riboflavin (1.8 mg/1) + Thiamine mononitrate (1.6 mg/1) + Thiamine mononitrate (1.6 mg/1) + Zinc oxide (25 mg/1) + Zinc oxide (25 mg/1)	Kit	Oral	Seton Pharmaceuticals	2010-06-04	2012-03-31
Cavan Folate DHA	DL-alpha tocopheryl acetate (30 [iU]/1) + DL-alpha tocopheryl acetate (30 [iU]/1) + Ascorbic acid (70 mg/1) + Ascorbic acid (70 mg/1) + Beta carotene (2700 [iU]/1) + Beta carotene (2700 [iU]/1) + Calcium carbonate (100 mg/1) + Calcium carbonate (100 mg/1) + Cholecalciferol (400 [iU]/1) + Cholecalciferol (400 [iU]/1) + Cupric oxide (2 mg/1) + Cupric oxide (2 mg/1) + Cyanocobalamin (12 ug/1) + Cyanocobalamin (12 ug/1) + Doconexent (250 mg/1) + Doconexent (250 mg/1) + Ferrous fumarate (65 mg/1) + Ferrous fumarate (65 mg/1) + Folic acid (1 mg/1) + Folic acid (1 mg/1) + Magnesium oxide (25 mg/1) + Magnesium oxide (25 mg/1) + Nicotinamide (18 mg/1) + Nicotinamide (18 mg/1) + Pyridoxine hydrochloride (2.5 mg/1) + Pyridoxine hydrochloride (2.5 mg/1) + Riboflavin (1.8 mg/1) + Riboflavin (1.8 mg/1) + Thiamine mononitrate (1.6 mg/1) + Thiamine mononitrate (1.6 mg/1) + Zinc oxide (25 mg/1) + Zinc oxide (25 mg/1)	Kit	Oral	Seton Pharmaceuticals	2010-06-04	2012-03-31
Cavan Folate OB	DL-alpha tocopheryl acetate (30 [iU]/1) + Ascorbic acid (70 mg/1) + Beta carotene (2700 [iU]/1) + Calcium carbonate (100 mg/1) + Cholecalciferol (400 [iU]/1) + Cupric oxide (2 mg/1) + Cyanocobalamin (12 ug/1) + Ferrous fumarate (65 mg/1) + Folic acid (1 mg/1) + Magnesium oxide (25 mg/1) + Nicotinamide (18 mg/1) + Pyridoxine hydrochloride (2.5 mg/1) + Riboflavin (1.8 mg/1) + Thiamine mononitrate (1.6 mg/1) + Zinc oxide (25 mg/1)	Tablet	Oral	Seton Pharmaceuticals	2010-08-23	2012-05-31
Cavan One	DL-alpha tocopheryl acetate (30 [iU]/1) + Calcium (150 mg/1) + Calcium ascorbate dihydrate (25 mg/1) + Cholecalciferol (170 [iU]/1) + Doconexent (260 mg/1) + Ferrous asparto glycinate (7 mg/1) + Folic acid (1 mg/1) + Icosapent (40 mg/1) + Iron (20 mg/1) + Linoleic acid (30 mg/1) + Pyridoxine hydrochloride (25 mg/1) + alpha-Linolenic acid (30 mg/1)	Capsule, gelatin coated	Oral	Seton Pharmaceuticals	2009-10-30	2011-11-27
Cavan-EC SOD DHA	DL-alpha tocopheryl acetate (30 mg/1) + Ascorbic acid (130 mg/1) + Beta carotene (3000 [iU]/1) + Calcium carbonate (230 mg/1) + Cholecalciferol (410 [iU]/1) + Cyanocobalamin (12 ug/1) + Folic acid (1 mg/1) + Magnesium oxide (25 mg/1) + Nicotinamide (20 mg/1) + Omega-3 fatty acids (440 mg/1) + Pyridoxine hydrochloride (28 mg/1) + Riboflavin (4 mg/1) + Sodium feredetate (30 mg/1) + Zinc oxide (26 mg/1)	Kit	Oral	Physicians Total Care, Inc.	2010-08-24	2013-01-15

Categories

Drug Categories

• Vitamin E
• Vitamins
• Vitamins (Fat Soluble)

Classification

Not classified

Affected organisms

Not Available

Chemical Identifiers

UNII

WR1WPI7EW8

CAS number

52225-20-4

InChI Key

ZAKOWWREFLAJOT-UHFFFAOYSA-N

InChI

InChI=1S/C31H52O3/c1-21(2)13-10-14-22(3)15-11-16-23(4)17-12-19-31(9)20-18-28-26(7)29(33-27(8)32)24(5)25(6)30(28)34-31/h21-23H,10-20H2,1-9H3

IUPAC Name

2,5,7,8-tetramethyl-2-(4,8,12-trimethyltridecyl)-3,4-dihydro-2H-1-benzopyran-6-yl acetate

SMILES

CC(C)CCCC(C)CCCC(C)CCCC1(C)CCC2=C(O1)C(C)=C(C)C(OC(C)=O)=C2C

References

General References

Not Available

External Links

Human Metabolome Database

HMDB0034227

ChemSpider

2033

RxNav

317841

ChEBI

182695

ChEMBL

CHEMBL247481

Clinical Trials

Clinical Trials

Phase	Status	Purpose	Conditions	Count
2, 3	Completed	Treatment	Substance Abuse / Substance Dependence	1
1	Withdrawn	Treatment	Burn Injuries	1
Not Available	Unknown Status	Treatment	Alcohol Dependency	1

Pharmacoeconomics

Manufacturers

Not Available

Packagers

Not Available

Dosage Forms

Form	Route	Strength
Solution / drops	Oral	50 unit / mL
Capsule	Oral
Capsule, coated	Oral	400 IU
Capsule, gelatin coated	Oral
Tablet	Oral
Lozenge	Oral
Liquid	Topical
Cloth	Topical
Liquid	Oral
Injection, solution, concentrate; kit	Intravenous
Injection, powder, lyophilized, for solution	Intravenous
Kit	Intravenous
Solution	Intravenous
Solution	Oral
Liquid	Intravenous
Capsule, liquid filled	Oral	0.6 mg
Capsule, delayed release	Oral
Capsule, gelatin coated; kit; tablet	Oral
Tablet, coated	Oral
Kit	Oral
Capsule, liquid filled	Oral
Tablet, film coated	Oral
Capsule; kit; tablet, coated	Oral
Capsule; kit; tablet, film coated	Oral
Capsule; kit; tablet	Oral
Injection, powder, lyophilized, for solution	Intramuscular; Intravenous
Tablet, chewable	Oral
Capsule	Oral	200 unit / cap
Capsule	Oral	1000 unit / cap
Capsule	Oral	800 unit / cap
Capsule, liquid filled	Oral	1000 IU
Capsule, liquid filled	Oral	1000 mg
Capsule, liquid filled	Oral	400 IU
Capsule	Oral	25 unit / cap
Powder	Oral
Capsule	Oral	400 unit / cap
Capsule	Oral

Prices

Not Available

Patents

Not Available

Properties

State

Not Available

Experimental Properties

Not Available

Predicted Properties

Property	Value	Source
logP	10.42	Chemaxon
pKa (Strongest Basic)	-4.9	Chemaxon
Physiological Charge	0	Chemaxon
Hydrogen Acceptor Count	2	Chemaxon
Hydrogen Donor Count	0	Chemaxon
Polar Surface Area	35.53 Å2	Chemaxon
Rotatable Bond Count	14	Chemaxon
Refractivity	144.53 m3·mol-1	Chemaxon
Polarizability	59.57 Å3	Chemaxon
Number of Rings	2	Chemaxon
Bioavailability	0	Chemaxon
Rule of Five	No	Chemaxon
Ghose Filter	No	Chemaxon
Veber's Rule	No	Chemaxon
MDDR-like Rule	No	Chemaxon

Predicted ADMET Features

Not Available

Spectra

Mass Spec (NIST)

Not Available

Spectra

Not Available

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Drug created at July 06, 2018 18:56 / Updated at December 01, 2022 11:28