DL-alpha tocopheryl acetate

This drug entry is a stub and has not been fully annotated. It is scheduled to be annotated soon.

Identification

Brand Names
Mvi Pediatric, Natafort
Generic Name
DL-alpha tocopheryl acetate
DrugBank Accession Number
DB14477
Background

Not Available

Type
Small Molecule
Groups
Approved, Experimental
Structure
Weight
Average: 472.754
Monoisotopic: 472.391645534
Chemical Formula
C31H52O3
Synonyms
  • all-rac-alfa-tocopheryl acetate
  • all-rac-alpha-tocopheryl acetate
  • DL-alpha-tocopheryl acetate

Pharmacology

Indication

Not Available

Reduce drug development failure rates
Build, train, & validate machine-learning models
with evidence-based and structured datasets.
See how
Build, train, & validate predictive machine-learning models with structured datasets.
See how
Associated Conditions
Indication TypeIndicationCombined Product DetailsApproval LevelAge GroupPatient CharacteristicsDose Form
Used in combination to treatDegenerative retinal disordersCombination Product in combination with: Pyridoxine (DB00165), Vitamin A (DB00162)•••••••••••••••••••
Used in combination to treatEye degenerative disorderCombination Product in combination with: Vitamin A (DB00162), Pyridoxine (DB00165)•••••••••••••••••••
Used in combination to treatVitamin deficiencyCombination Product in combination with: Vitamin A (DB00162), Pyridoxine (DB00165)•••••••••••••••••••
Treatment ofVitamin e deficiency••• ••••••••••
Contraindications & Blackbox Warnings
Prevent Adverse Drug Events Today
Tap into our Clinical API for life-saving information on contraindications & blackbox warnings, population restrictions, harmful risks, & more.
Learn more
Avoid life-threatening adverse drug events with our Clinical API
Learn more
Pharmacodynamics

Not Available

Mechanism of action
Not Available
Absorption

Not Available

Volume of distribution

Not Available

Protein binding

Not Available

Metabolism
Not Available
Route of elimination

Not Available

Half-life

Not Available

Clearance

Not Available

Adverse Effects
Improve decision support & research outcomes
With structured adverse effects data, including: blackbox warnings, adverse reactions, warning & precautions, & incidence rates. View sample adverse effects data in our new Data Library!
See the data
Improve decision support & research outcomes with our structured adverse effects data.
See a data sample
Toxicity

Not Available

Pathways
Not Available
Pharmacogenomic Effects/ADRs
Not Available

Interactions

Drug Interactions
This information should not be interpreted without the help of a healthcare provider. If you believe you are experiencing an interaction, contact a healthcare provider immediately. The absence of an interaction does not necessarily mean no interactions exist.
DrugInteraction
OrlistatOrlistat can cause a decrease in the absorption of DL-alpha tocopheryl acetate resulting in a reduced serum concentration and potentially a decrease in efficacy.
Food Interactions
No interactions found.

Products

Drug product information from 10+ global regions
Our datasets provide approved product information including:
dosage, form, labeller, route of administration, and marketing period.
Access now
Access drug product information from over 10 global regions.
Access now
Active Moieties
NameKindUNIICASInChI Key
Vitamin EprodrugN9PR3490H959-02-9GVJHHUAWPYXKBD-IEOSBIPESA-N
DL-alpha-Tocopherolprodrug7QWA1RIO0110191-41-0GVJHHUAWPYXKBD-UHFFFAOYSA-N
Product Images
Over the Counter Products
NameDosageStrengthRouteLabellerMarketing StartMarketing EndRegionImage
Aquasol E Drops 50unit/mlSolution / drops50 unit / mLOralRhone Poulenc Rorer1993-12-311997-08-13Canada flag
E Vitamin 200I.U. (synthetic Source) - CapCapsule200 unit / capOralH.J. Sutton Industries Ltd.1996-10-251998-08-31Canada flag
E Vitamin 400 I.U. (synthetic Source)-capCapsule400 unit / capOralH.J. Sutton Industries Ltd.1996-10-251998-08-31Canada flag
E Vitamin 800I.U.(synthetic Source)-capCapsule800 unit / capOralH.J. Sutton Industries Ltd.1996-10-251998-08-31Canada flag
Vitamin E 200iu With Non-med.odorless GarlicCapsule200 unit / capOralPharmavite1996-09-062003-07-30Canada flag
Mixture Products
NameIngredientsDosageRouteLabellerMarketing StartMarketing EndRegionImage
A/o-26 - CapletDL-alpha tocopheryl acetate (100 unit) + Beta carotene (7500 unit) + Calcium (75 mg) + Calcium ascorbate (250 mg) + Copper (1 mg) + Folic acid (.4 mg) + Manganese (2.5 mg) + Racemethionine (50 mg) + Selenium (100 mcg) + Zinc (7.5 mg)TabletOralEnviro Tech International Canada1996-12-191999-07-26Canada flag
Balance Ace - CapDL-alpha tocopheryl acetate (200 unit) + Ascorbic acid (250 mg) + Beta carotene (10000 unit) + Cupric oxide (1 mg) + Manganese sulfate (1.5 mg) + Sodium selenate (15 mcg) + Zinc oxide (7.5 mg)CapsuleOralPharmavite1996-09-062002-07-25Canada flag
Beta C and E TabDL-alpha tocopheryl acetate (200 unit / tab) + Ascorbic acid (250 mg / tab) + Beta carotene (5000 unit / tab)TabletOralKsl Pharmaceuticals1994-12-311997-08-08Canada flag
Betacept Special Formula Vitamins CapDL-alpha tocopheryl acetate (200 unit / cap) + Ascorbic acid (250 mg / cap) + Beta carotene (10000 unit / cap)CapsuleOralWampole Brands, A Division Of Pangeo Pharma (Canada) Inc.1993-12-312002-07-29Canada flag
Children's Chew Multi & Min TabDL-alpha tocopheryl acetate (15 unit / tab) + Ascorbic acid (30 mg / tab) + Beta carotene (1250 unit / tab) + Biotin (75 mcg / tab) + Calcium carbonate (100 mg / tab) + Choline bitartrate (5 mg / tab) + Copper gluconate (1 mg / tab) + Cyanocobalamin (5 mcg / tab) + Ferrous gluconate (2.5 mg / tab) + Iodine (.075 mg / tab) + Magnesium oxide (25 mg / tab) + Manganese gluconate (.5 mg / tab) + Nicotinamide (10 mg / tab) + Calcium pantothenate (6.25 mg / tab) + Potassium chloride (.5 mg / tab) + Potassium chloride (5 mg / tab) + Pyridoxine hydrochloride (1.25 mg / tab) + Riboflavin (1.25 mg / tab) + Thiamine hydrochloride (1.25 mg / tab) + Vitamin A palmitate (1250 unit / tab) + Vitamin D (200 unit / tab) + Zinc gluconate (1.25 mg / tab)TabletOralNatrol, Inc.1995-12-312001-07-30Canada flag
Unapproved/Other Products
NameIngredientsDosageRouteLabellerMarketing StartMarketing EndRegionImage
AbaviteDL-alpha tocopheryl acetate (13.5 mg/1) + Ascorbic acid (60 mg/1) + Cholecalciferol (0.025 mg/1) + Ferrous sulfate (30 mg/1) + Folic acid (1 mg/1) + Magnesium oxide (25 mg/1) + Mecobalamin (0.5 mg/1) + Niacin (15 mg/1) + Calcium pantothenate (5 mg/1) + Potassium Iodide (0.25 mg/1) + Riboflavin (1.8 mg/1) + Thiamine mononitrate (1.6 mg/1) + Vitamin A palmitate (0.33 mg/1) + Zinc oxide (15 mg/1)TabletOralABACOS HEALTH2021-03-31Not applicableUS flag
Active FEDL-alpha tocopheryl acetate (40 [iU]/1) + Ascorbic acid (160 mg/1) + Beta carotene (2100 [iU]/1) + Cholecalciferol (400 [iU]/1) + Cupric oxide (1 mg/1) + Cyanocobalamin (30 ug/1) + Folic acid (1250 ug/1) + Iron (75 mg/1) + Magnesium oxide (30 mg/1) + Nicotinamide (20 mg/1) + Pyridoxine hydrochloride (20 mg/1) + Riboflavin (4 mg/1) + Thiamine hydrochloride (4 mg/1) + Zinc oxide (20 mg/1)TabletOralGm Pharmaceuticals2013-11-11Not applicableUS flag
Bal-Care DHADL-alpha tocopheryl acetate (3 mg/1) + Ascorbic acid (120 mg/1) + Beta carotene (2850 [iU]/1) + Calcium carbonate (219 mg/1) + Cholecalciferol (840 [iU]/1) + Cupric oxide (2 mg/1) + Cyanocobalamin (.012 mg/1) + Folic acid (1 mg/1) + Iodine (.223 mg/1) + Iron sucrose (1.35 mg/1) + Magnesium oxide (25 mg/1) + Nicotinamide (20 mg/1) + Omega-3 fatty acids (430 mg/1) + Pyridoxine hydrochloride (50 mg/1) + Riboflavin (4 mg/1) + Sodium feredetate (25.65 mg/1) + Thiamine mononitrate (1.8 mg/1) + Zinc oxide (25 mg/1)KitOralPru Gen Pharmaceuticals2012-05-01Not applicableUS flag
Bal-Care DHA EssentialDL-alpha tocopheryl acetate (3 mg/1) + Ascorbic acid (120 mg/1) + Beta carotene (2850 [iU]/1) + Calcium carbonate (219 mg/1) + Cholecalciferol (840 [iU]/1) + Cupric oxide (2 mg/1) + Cyanocobalamin (.012 mg/1) + Folic acid (1 mg/1) + Iodine (.223 mg/1) + Iron sucrose (1.35 mg/1) + Magnesium oxide (25 mg/1) + Nicotinamide (20 mg/1) + Omega-3 fatty acids (374 mg/1) + Pyridoxine hydrochloride (50 mg/1) + Riboflavin (4 mg/1) + Sodium feredetate (25.65 mg/1) + Thiamine mononitrate (1.8 mg/1) + Zinc oxide (25 mg/1)KitOralPru Gen Pharmaceuticals2012-05-01Not applicableUS flag
Cavan AlphaDL-alpha tocopheryl acetate (3 mg/1) + Ascorbic acid (120 mg/1) + Beta carotene (3000 [iU]/1) + Calcium carbonate (230 mg/1) + Cholecalciferol (800 [iU]/1) + Cupric oxide (2 mg/1) + Cyanocobalamin (12 ug/1) + Folic acid (1 mg/1) + Iodine (220 ug/1) + Iron (27 mg/1) + Magnesium oxide (25 mg/1) + Nicotinamide (20 mg/1) + Omega-3 fatty acids (300 mg/1) + Pyridoxine hydrochloride (50 mg/1) + Riboflavin (4 mg/1) + Thiamine mononitrate (1.8 mg/1) + Zinc oxide (25 mg/1)KitOralSeton Pharmaceuticals2010-07-012013-09-30US flag

Categories

Drug Categories
Classification
Not classified
Affected organisms
Not Available

Chemical Identifiers

UNII
WR1WPI7EW8
CAS number
52225-20-4
InChI Key
ZAKOWWREFLAJOT-UHFFFAOYSA-N
InChI
InChI=1S/C31H52O3/c1-21(2)13-10-14-22(3)15-11-16-23(4)17-12-19-31(9)20-18-28-26(7)29(33-27(8)32)24(5)25(6)30(28)34-31/h21-23H,10-20H2,1-9H3
IUPAC Name
2,5,7,8-tetramethyl-2-(4,8,12-trimethyltridecyl)-3,4-dihydro-2H-1-benzopyran-6-yl acetate
SMILES
CC(C)CCCC(C)CCCC(C)CCCC1(C)CCC2=C(O1)C(C)=C(C)C(OC(C)=O)=C2C

References

General References
Not Available
Human Metabolome Database
HMDB0034227
ChemSpider
2033
RxNav
317841
ChEBI
182695
ChEMBL
CHEMBL247481

Clinical Trials

Clinical Trials
PhaseStatusPurposeConditionsCount
2, 3CompletedTreatmentSubstance Abuse / Substance Dependence1
1CompletedOtherAnemia1
1WithdrawnTreatmentBurn Injury1
Not AvailableUnknown StatusTreatmentAlcohol Dependency1

Pharmacoeconomics

Manufacturers
Not Available
Packagers
Not Available
Dosage Forms
FormRouteStrength
Solution / dropsOral50 unit / mL
CapsuleOral
Capsule, coatedOral400 IU
Capsule, gelatin coatedOral
TabletOral
LozengeOral
LiquidTopical
ClothTopical
LiquidOral
Injection, solution, concentrate; kitIntravenous
Injection, powder, lyophilized, for solutionIntravenous
KitIntravenous
SolutionIntravenous
SolutionOral
LiquidIntravenous
Capsule, liquid filled; kit; tabletOral
Capsule, liquid filled; kit; tablet, film coatedOral
Capsule, delayed releaseOral
Capsule, gelatin coated; kit; tabletOral
Tablet, coatedOral
KitOral
Capsule, liquid filledOral
Tablet, film coatedOral
Capsule; kit; tablet, coatedOral
Capsule; kit; tablet, film coatedOral
Capsule; kit; tabletOral
Injection, powder, lyophilized, for solutionIntramuscular; Intravenous
Tablet, chewableOral
CapsuleOral200 unit / cap
CapsuleOral1000 unit / cap
CapsuleOral800 unit / cap
Capsule, liquid filledOral1000 IU
Capsule, liquid filledOral1000 mg
Capsule, liquid filledOral400 IU
CapsuleOral25 unit / cap
PowderOral
CapsuleOral400 unit / cap
CapsuleOral
Prices
Not Available
Patents
Not Available

Properties

State
Not Available
Experimental Properties
Not Available
Predicted Properties
PropertyValueSource
logP10.42Chemaxon
pKa (Strongest Basic)-4.9Chemaxon
Physiological Charge0Chemaxon
Hydrogen Acceptor Count2Chemaxon
Hydrogen Donor Count0Chemaxon
Polar Surface Area35.53 Å2Chemaxon
Rotatable Bond Count14Chemaxon
Refractivity144.53 m3·mol-1Chemaxon
Polarizability59.57 Å3Chemaxon
Number of Rings2Chemaxon
Bioavailability0Chemaxon
Rule of FiveNoChemaxon
Ghose FilterNoChemaxon
Veber's RuleNoChemaxon
MDDR-like RuleNoChemaxon
Predicted ADMET Features
Not Available

Spectra

Mass Spec (NIST)
Not Available
Spectra
SpectrumSpectrum TypeSplash Key
Predicted MS/MS Spectrum - 10V, Positive (Annotated)Predicted LC-MS/MSsplash10-00di-3031900000-7f12936e1677f07e3ac1
Predicted MS/MS Spectrum - 10V, Negative (Annotated)Predicted LC-MS/MSsplash10-00b9-0000900000-fb1577f3e93415fffde4
Predicted MS/MS Spectrum - 20V, Negative (Annotated)Predicted LC-MS/MSsplash10-0a4i-9000100000-068498bcc2744d5a75df
Predicted MS/MS Spectrum - 20V, Positive (Annotated)Predicted LC-MS/MSsplash10-060r-9216300000-e84db64d7d376799e31c
Predicted MS/MS Spectrum - 40V, Negative (Annotated)Predicted LC-MS/MSsplash10-0bti-4001900000-203db291537a6a7415d1
Predicted MS/MS Spectrum - 40V, Positive (Annotated)Predicted LC-MS/MSsplash10-0api-9340100000-dad501303885af430c99
Predicted 1H NMR Spectrum1D NMRNot Applicable
Predicted 13C NMR Spectrum1D NMRNot Applicable
Chromatographic Properties
Collision Cross Sections (CCS)
AdductCCS Value (Å2)Source typeSource
[M-H]-248.9413355
predicted
DarkChem Lite v0.1.0
[M-H]-220.67792
predicted
DeepCCS 1.0 (2019)
[M+H]+248.8047355
predicted
DarkChem Lite v0.1.0
[M+H]+224.01811
predicted
DeepCCS 1.0 (2019)
[M+Na]+249.6283355
predicted
DarkChem Lite v0.1.0
[M+Na]+232.83318
predicted
DeepCCS 1.0 (2019)

Drug created at July 06, 2018 18:56 / Updated at December 01, 2022 11:28