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Doxofylline
go.drugbank.com/drugs/DB09273InvestigationalDoxofylline is a methylxanthine derivative with the presence of a dioxolane group in position 7. As a drug used in the treatment of asthma, doxofylline has shown similar efficacy to theophylline but with significantly fewer side effects ...
Categories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP1A2 SubstratesArtesunate
go.drugbank.com/drugs/DB09274ApprovedInvestigationalArtesunate is indicated for the initial treatment of severe malaria. The World Health Organization recommends artesunate as first line treatment for severe malaria. Artesunate was developed out of a need for a more hydrophilic derivative...
Categories: P-glycoprotein substrates, Cytochrome P-450 SubstratesPropacetamol
go.drugbank.com/drugs/DB09288InvestigationalPropacetamol is a non-opioid analgesic devoid of the major contraindications. It is a derivative of acetaminophen, or paracetamol, with the molecular formula glycine, N, N-diethyl-,4-(acetylamino)phenyl ester. Propacetamol is a parentera...
Categories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP3A InducersRamosetron
go.drugbank.com/drugs/DB09290InvestigationalRamosetron is a serotonin 5-HT3 receptor antagonist commonly employed to treat nausea and vomiting, in addition to certain diarrheal conditions. It is believed to have higher potency and longer antiemetic action than other 1st generation...
Categories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP1A2 SubstratesRolapitant
go.drugbank.com/drugs/DB09291ApprovedInvestigationalNeurokinin-1 is also known as Tachykinin Receptor 1 (TACR1), Neurokinin 1 Receptor (NK1R), and Substance P Receptor (SPR). … By blocking Substance P from interacting with NK-1 receptors in the gut and the central nervous system, rolapitant prevents late-phase CINV.
Categories: P-glycoprotein inhibitors, Cytochrome P-450 SubstratesKitasamycin
go.drugbank.com/drugs/DB09309ExperimentalKitasamycin is a macrolide antibiotic derived from Streptomyces kitasatoensis.
Categories: Cytochrome P-450 CYP3A Inhibitors, Cytochrome P-450 CYP3A4 InhibitorsSynthetic Conjugated Estrogens, A
go.drugbank.com/drugs/DB09317ApprovedSynthetic conjugated estrogens A are composed of a blend of the following nine synthetic estrogenic substances: estrone sulfate, sodium equilin sulfate, sodium 17α-dihydroequilin sulfate, sodium 17α-estradiol sulfate, sodium 17β dihydro...
Categories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP3A SubstratesPramocaine
go.drugbank.com/drugs/DB09345ApprovedPramocaine (also known as pramoxine or pramoxine HCI) is a topical anesthetic and antipruritic. It is used for many dermatological and anorectal/anogenital conditions including minor cuts/burns, insect bites, hives/rashes due to poison i...
Mixtures: Sarna PNorethynodrel
go.drugbank.com/drugs/DB09371ApprovedA synthetic progestational hormone with actions and uses similar to those of PROGESTERONE. It has been used in the treatment of functional uterine bleeding and endometriosis. As a contraceptive, it has usually been administered in combin...
Categories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP3A SubstratesNavamepent
go.drugbank.com/drugs/DB21096InvestigationalNavamepent is a small molecule drug. Navamepent is under investigation in clinical trial NCT02329743 (Efficacy and Safety of RX-10045 Ophthalmic Solution for Ocular Inflammation and Pain in Cataract Surgery). Navamepent has a monoisotopi...
Categories: P-glycoprotein inhibitors