Artesunate is artesunate is an artemesinin derivative indicated for the initial treatment of severe malaria. Artesunate was developed out of a need for a more hydrophilic derivative of artemisinin.
- Mechanism
- Curator reviewed · 5 references
Artesunate is metabolized to the active DHA. the endoperoxide bridge of DHA reacts with heme, generating free radicals which inhibit protein and nucleic acid synthesis of the Plasmodium parasites during all erythrocytic stages. Reactions with these free radicals can also lead to alkylation of parasitic proteins such as a calcium adenosine triphosphatase and EXP1, a glutathione S-transferase.
- Primary indication
- Artesunate is indicated for the initial treatment of severe malaria in adult and pediatric patients.Curator reviewed · 4 structured indications
- Formula / weight
- C19H28O8 · 384.425 g/mol (avg)
- First approval
- Canada, 2025 · United States, 2020 · European Union, 2022
- Also known as
- Artesunic acid
- Code names
- 182824-33-5 · NSC-712571
- Brand names
Resolves to
FIHJKUPKCHIPAT-AHIGJZGOSA-NSMILES[H][C@@]12CC[C@@H](C)[C@]3([H])CC[C@@]4(C)OO[C@@]13[C@]([H])(O[C@@H](OC(=O)CCC(O)=O)[C@@H]2C)O4What you can answer from here — as of August 30, 2026
Which drugs share a target with Artesunate, and which of those have an active Phase 3 trial?
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