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Hyaluronidase (human recombinant)
go.drugbank.com/drugs/DB06205ApprovedInvestigational[A199047] Hyaluronidase was first used in prescription products in the United States on 5 May 2004.[L13338] … Hyaluronidase (human recombinant) (INN Vorhyaluronidase alfa) is produced by genetically engineered Chinese Hamster Ovary (CHO) cells containing a DNA plasmid encoding for a soluble fragment of human hyaluronidase
Benserazide
go.drugbank.com/drugs/DB12783ApprovedInvestigationalA decarboxylase inhibitor like benserazide is consequently an effective compound to combine with levadopa as it is incapable of crossing the blood-brain barrier itself but acts to prevent the formation … This can result in a number of side effects like nausea, vomiting, or even cardiac arrhythmias that may diminish patient adherence [F2, L2553].
Mixtures: Prolopa Cap 100-25, Prolopa Cap 200-50Categories: Aromatic L-amino Acid Decarboxylase InhibitorsCaplacizumab
go.drugbank.com/drugs/DB06081ApprovedInvestigationalCaplacizumab was developed by Ablynx, a Sanofi company and FDA approved on February 6, 2019,[L5302] and approved previously by the EU in October 2018 as a combination therapy with plasma exchange and immunosuppression … Caplacizumab, firstly called ALX-0081, is a humanized single-variable-domain immunoglobulin consisting of two identical humanized building blocks genetically linked by a three-alanine linker.
Products: CABLIVI®, Cablivi 10 mg/1 mL Enjeksiyonluk Çözelti Hazırlamak İçin Toz ve Çözücü, 1 ADETRho-associated protein kinase 1
go.drugbank.com/bio_entities/BE0001016TargetHumansProtein kinase which is a key regulator of the actin cytoskeleton and cell polarity (PubMed:10436159, PubMed:10652353, PubMed:11018042, PubMed:11283607, PubMed:17158456, PubMed:18573880, PubMed:19131646, PubMed:8617235, PubMed:9722579). ...
Synonyms: ROCK-I, Rho-associated, coiled-coil-containing protein kinase IFondaparinux
go.drugbank.com/drugs/DB00569ApprovedInvestigationalOnce bound to heparin or HS, the anticoagulant activity of ATIII is potentiated by 1000-fold. Fondaparinux potentiates the neutralizing action of ATIII on activated Factor X 300-fold. … angina (UA) and non-ST segment elevation myocardial infarction (NSTEMI); and in the management of ST segment elevation myocardial infarction (STEMI).
Products: ARIXTRA ® 10MG /0.8 ML, ARIXTRA ® 7.5 MG /0.6 MLLonapegsomatropin
go.drugbank.com/drugs/DB16220ApprovedInvestigational[L36380,L10971] Lonapegsomatropin was granted FDA approval on 25 August 2021.[L36380] It was later approved by the European Commission on 13 January 2022.[L39900] … [A237605,L36380,L36405] Unlike somatropin, which requires daily dosing, lonapegsomatropin can be administered as a single weekly dose.
Categories: P-glycoprotein substrates, Cytochrome P-450 CYP1A2 InducersQuinohemoprotein alcohol dehydrogenase
go.drugbank.com/bio_entities/BE0001870TargetComamonas testosteroniCatalyzes the dye-linked oxidation of primary alcohols to the corresponding aldehydes and the (subsequent) oxidation of the aldehydes to carboxylic acids. Methanol is not a substrate.
Synonyms: Quinohaemoprotein ethanol dehydrogenase type I, Quinohemoprotein ethanol dehydrogenase type IHetacillin
go.drugbank.com/drugs/DB00739ApprovedVet approvedWithdrawnThe name "penicillin" can either refer to several variants of penicillin available, or to the group of antibiotics derived from the penicillins. … Hetacillin is a penicillin beta-lactam antibiotic used in the treatment of bacterial infections caused by susceptible, usually gram-positive, organisms.
Categories: Heterocyclic Compounds, 2-RingSynonyms: (2S,5R,6R)-6-[(4R)-2,2-dimethyl-5-oxo-4-phenylimidazolidin-1-yl]-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid, 6β-[(4R)-2,2-dimethyl-5-oxo-4-phenylimidazolidin-1-yl]penicillanic acidNADH dehydrogenase [ubiquinone] iron-sulfur protein 8, mitochondrial
go.drugbank.com/bio_entities/BE0000037TargetHumansEssential for the catalytic activity and assembly of complex I (PubMed:22499348) … Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) which catalyzes electron transfer from NADH through the respiratory chain, using ubiquinone as an electron acceptor
Synonyms: Complex I-23kDNADH dehydrogenase [ubiquinone] iron-sulfur protein 6, mitochondrial
go.drugbank.com/bio_entities/BE0000093TargetHumansAccessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. … Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone
Synonyms: Complex I-13kD-A