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Displaying results 1261 - 1270 of 10000 in total
  1. Drug

    Dexloxiglumide

    go.drugbank.com/drugs/DB04856
    Investigational

    Dexloxiglumide is a selective cholecystokinin type A (CCKA) receptor antagonist in phase III testing by Rottapharm in Europe only, as U.S. trials have been discontinued. … As the D-isomer of loxiglumide, it retains all pharmacological properties of loxiglumide but is more potent.

    Categories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP2B6 Substrates
  2. Drug

    Propofol

    go.drugbank.com/drugs/DB00818
    ApprovedInvestigationalVet approved

    IV administration of propfol is used to induce unconsciousness after which anaesthesia may be maintained using a combination of medications. … Propofol is an intravenous anaesthetic agent used for induction and maintenance of general anaesthesia.

    Mixtures: Anesthesia S/I-60, Anesthesia S/I-40Categories: P-glycoprotein inducers, Cytochrome P-450 Substrates
  3. Drug

    Sennosides

    go.drugbank.com/drugs/DB11365
    ApprovedInvestigational

    It is a weaker laxative than bisacodyl or castor oil[A177092]. … Sennosides (also known as senna glycoside or senna) is a medication used to treat constipation[FDA Label][L771] and empty the large intestine before surgery.

    Salts: Sennosides A and BMixtures: Senna-S, Senexon-S
  4. Drug

    Gluconic Acid

    go.drugbank.com/drugs/DB13180
    ApprovedInvestigational

    Gluconic acid or gluconate is used to maintain the cation-anion balance on electrolyte solutions.

    Mixtures: Isolyte S, Isolyte S pH 7.4Synonyms: D-Gluconic Acid
  5. Drug

    Sodium phosphate, dibasic

    go.drugbank.com/drugs/DB14502
    ApprovedInvestigational

    Synonyms: Phosphoric acid, sodium salt (1:2)Mixtures: ISOLYTE-S PH 7.4 PVC 500 ML(SETLI), ISOLYTE-S PH 7.4 PVC 1000 ML(SETLI)
  6. Drug

    Ivosidenib

    go.drugbank.com/drugs/DB14568
    ApprovedInvestigational

    Ivosidenib is a first-in-class isocitrate dehydrogenase-1 (IDH1) inhibitor. … The drug is only effective in patients with a susceptible IDH1 mutation.

    Categories: P-glycoprotein substrates with a Narrow Therapeutic Index, Cytochrome P-450 CYP3A4 Substrates with a Narrow Therapeutic Index
  7. Target

    Neuronal acetylcholine receptor subunit alpha-10

    go.drugbank.com/bio_entities/BE0000411
    TargetHumans

    by a collection of nAChR subunits. … Component of neuronal acetylcholine receptors (nAChRs) that function as pentameric, ligand-gated cation channels with high calcium permeability. nAChRs are excitatory neurotrasnmitter receptors formed

    Synonyms: NACHR alpha-10
  8. Drug

    Myrcludex B

    go.drugbank.com/drugs/DB14853
    Investigational

    Myrcludex B is under investigation in clinical trial NCT03546621 (A Multicenter, Open-label, Randomized Clinical Study to Assess Efficacy and Safety of 3 Doses of Myrcludex B for 24 Weeks in Combination … With Tenofovir Compared to Tenofovir Alone to Suppress HBV Replication in Patients With Chronic Hepatitis D).

    Synonyms: Myrcludex B
  9. Drug

    Formestane

    go.drugbank.com/drugs/DB08905
    ApprovedWithdrawn

    It is not US FDA approved, and the intramuscular injection form of formestane (Lentaron) which was approved in Europe has been withdrawn. … It is listed as a prohibited substance by the World Anti-Doping Agency for use in athletes.

    Categories: Cytochrome P-450 CYP3A Inducers, Cytochrome P-450 CYP3A4 InducersSynonyms: 4-OH-A, 4-hydroxy-4-androstene-3,17-dione
  10. Drug

    Silodosin

    go.drugbank.com/drugs/DB06207
    ApprovedInvestigational

    [A231159] Silodosin was first approved by the FDA in October 2008 [A231159] and it is also approved in Europe and Canada. … Silodosin is a selective antagonist of alpha(α)-1 adrenergic receptors that binds to the α<sub>1A</sub> subtype with the highest affinity. α1-adrenergic receptors regulate smooth muscle tone in the bladder

    Categories: Cytochrome P-450 Substrates, P-glycoprotein substratesProducts: SILOPROST® 8, FENANTA® 8 MG